| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Lupus Vulgaris | D008177 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Ganglioneuroma | D005729 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Bone Marrow Neoplasms | D019046 | 2 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Progeria | D011371 | 3 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Uveal Neoplasms | D014604 | 3 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Conjunctival Neoplasms | D003230 | 3 associated lipids |
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
| Lymphoma, Follicular | D008224 | 3 associated lipids |
| Cicatrix, Hypertrophic | D017439 | 4 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Nasopharyngeal Neoplasms | D009303 | 4 associated lipids |
| Neuroendocrine Tumors | D018358 | 4 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Opioid-Related Disorders | D009293 | 5 associated lipids |
| Osteomalacia | D010018 | 5 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Myeloproliferative Disorders | D009196 | 5 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17600477 |
| Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17679169 |
| Cao QF et al. | TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. | 2015 | Cancer Biother. Radiopharm. | pmid:25760728 |
| Yamashita K et al. | Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. | 2002 | Cancer Cell | pmid:12498717 |
| Gius D et al. | Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. | 2004 | Cancer Cell | pmid:15488759 |
| Maecker HL et al. | Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. | 2002 | Cancer Cell | pmid:12204534 |
| Jiang X et al. | DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. | 2008 | Cancer Cell | pmid:18538736 |
| Brugarolas JB et al. | TSC2 regulates VEGF through mTOR-dependent and -independent pathways. | 2003 | Cancer Cell | pmid:12957289 |
| Yoshida M et al. | Histone deacetylase as a new target for cancer chemotherapy. | 2001 | Cancer Chemother. Pharmacol. | pmid:11587361 |
| Bovenzi V and Momparler RL | Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. | 2001 | Cancer Chemother. Pharmacol. | pmid:11488527 |
| Whang YM et al. | Hyperacetylation enhances the growth-inhibitory effect of all-trans retinoic acid by the restoration of retinoic acid receptor beta expression in head and neck squamous carcinoma (HNSCC) cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15959780 |
| Kang J et al. | Synergistic killing of human leukemia cells by antioxidants and trichostatin A. | 2004 | Cancer Chemother. Pharmacol. | pmid:15248029 |
| Fandy TE and Srivastava RK | Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. | 2006 | Cancer Chemother. Pharmacol. | pmid:16435155 |
| Wunder T et al. | Expression of the coxsackie adenovirus receptor in neuroendocrine lung cancers and its implications for oncolytic adenoviral infection. | 2013 | Cancer Gene Ther. | pmid:23196273 |
| El-Zawahry A et al. | In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. | 2006 | Cancer Gene Ther. | pmid:16167063 |
| Katsura T et al. | The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells. | 2009 | Cancer Gene Ther. | pmid:18949013 |
| Zhou X et al. | The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. | 2007 | Cancer Genet. Cytogenet. | pmid:17693185 |
| Mazzio EA and Soliman KFA | Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. | Cancer Genomics Proteomics | pmid:30194076 | |
| Mazzio EA and Soliman KF | HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. | 2017 | Cancer Genomics Proteomics | pmid:28031235 |
| Shin S et al. | Trichostatin A Sensitizes Hepatocellular Carcinoma Cells to Enhanced NK Cell-mediated Killing by Regulating Immune-related Genes. | Cancer Genomics Proteomics | pmid:28871002 | |
| Khan AN et al. | An epigenetically altered tumor cell vaccine. | 2004 | Cancer Immunol. Immunother. | pmid:14997346 |
| Khan AN et al. | Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. | 2008 | Cancer Immunol. Immunother. | pmid:18046553 |
| Tiper IV and Webb TJ | Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. | 2016 | Cancer Immunol. Immunother. | pmid:27614429 |
| Neumann F et al. | EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors. | 2013 | Cancer Immunol. Immunother. | pmid:23619976 |
| Meng CF et al. | Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells. | 2010 | Cancer Invest. | pmid:19857042 |
| Fang Y et al. | Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. | 2011 | Cancer Invest. | pmid:21345073 |
| Liu Y et al. | Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines. | 2008 | Cancer Invest. | pmid:18584348 |
| Mousa SA et al. | Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. | 2010 | Cancer Lett. | pmid:19733430 |
| Sugimoto S et al. | Expression and regulation of tumor suppressor gene maspin in human bladder cancer. | 2004 | Cancer Lett. | pmid:14732229 |
| Li Y et al. | Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. | 2012 | Cancer Lett. | pmid:22266186 |
| Jung EJ et al. | Lytic induction and apoptosis of Epstein-Barr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir. | 2007 | Cancer Lett. | pmid:16647201 |
| Davies GF et al. | Troglitazone inhibits histone deacetylase activity in breast cancer cells. | 2010 | Cancer Lett. | pmid:19699029 |
| Hostetter CL et al. | Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. | 2009 | Cancer Lett. | pmid:19013015 |
| Francisco R et al. | Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | 2012 | Cancer Lett. | pmid:22186300 |
| Pitta CA et al. | Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. | 2013 | Cancer Lett. | pmid:23752064 |
| Nair AR et al. | Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. | 2001 | Cancer Lett. | pmid:11295287 |
| Zhang Q et al. | Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis. | 2014 | Cancer Lett. | pmid:25109451 |
| Liu RF et al. | Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. | 2013 | Cancer Lett. | pmid:23142219 |
| Chen H et al. | LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. | 2012 | Cancer Lett. | pmid:22743615 |
| Januchowski R et al. | Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. | 2007 | Cancer Lett. | pmid:16624484 |
| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Bharadwaj S and Prasad GL | Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. | 2002 | Cancer Lett. | pmid:12065096 |
| Bazhin AV et al. | Expression of GAGE family proteins in malignant melanoma. | 2007 | Cancer Lett. | pmid:17194529 |
| Al-Rayyan N et al. | 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. | 2014 | Cancer Lett. | pmid:24513177 |
| Chen Z et al. | Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. | 2002 | Cancer Lett. | pmid:12406558 |
| Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
| Ryu JK et al. | SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. | 2006 | Cancer Lett. | pmid:16009488 |
| Jung JW et al. | Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. | 2006 | Cancer Lett. | pmid:16337085 |
| Ohike N et al. | Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas. | 2003 | Cancer Lett. | pmid:12969792 |
| Hoebeeck J et al. | Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. | 2009 | Cancer Lett. | pmid:18819746 |