| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Lupus Vulgaris | D008177 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Ganglioneuroma | D005729 | 2 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Bone Marrow Neoplasms | D019046 | 2 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
| Lymphoma, Follicular | D008224 | 3 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Progeria | D011371 | 3 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Uveal Neoplasms | D014604 | 3 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Conjunctival Neoplasms | D003230 | 3 associated lipids |
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Cicatrix, Hypertrophic | D017439 | 4 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Nasopharyngeal Neoplasms | D009303 | 4 associated lipids |
| Neuroendocrine Tumors | D018358 | 4 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Myeloproliferative Disorders | D009196 | 5 associated lipids |
| Opioid-Related Disorders | D009293 | 5 associated lipids |
| Osteomalacia | D010018 | 5 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Carcinoma, Pancreatic Ductal | D021441 | 6 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yang X et al. | CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. | 2009 | PLoS ONE | pmid:19340297 |
| Slattery EL et al. | Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. | 2009 | J. Assoc. Res. Otolaryngol. | pmid:19340485 |
| Vilar E et al. | Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. | 2009 | Clin. Cancer Res. | pmid:19351759 |
| Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
| Luo SF et al. | Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19281832 |
| Giannini G et al. | N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19285395 |
| Ueda JY et al. | JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. | 2009 | J. Antibiot. | pmid:19300468 |
| Noro R et al. | The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application. | 2009 | J Nippon Med Sch | pmid:19305113 |
| Glenn DJ et al. | Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. | 2009 | Hypertension | pmid:19139378 |
| Deng G et al. | Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. | 2009 | Clin. Cancer Res. | pmid:19223499 |
| Sterthaus O et al. | Evaluation of in vitro cultured rat oocytes, from different strains, by spindle morphology and maturation-promoting-factor activity combined with nuclear-transfer experiments. | 2009 | Cloning Stem Cells | pmid:19751114 |
| Wang X et al. | Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. | 2009 | Cancer Res. | pmid:19752087 |
| Hirata H et al. | Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. | 2009 | Clin. Cancer Res. | pmid:19755393 |
| Chiou SK and Hoa N | Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. | 2009 | Apoptosis | pmid:19757064 |
| Vire B et al. | Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. | 2009 | PLoS ONE | pmid:19759901 |
| Lugrin J et al. | Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. | 2009 | Biochim. Biophys. Acta | pmid:19747950 |
| Cervera RP et al. | Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. | 2009 | Theriogenology | pmid:19765811 |
| Diplas AI et al. | Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. | 2009 | Nucleic Acids Res. | pmid:19767614 |
| Ma XX et al. | Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. | 2009 | Eur. J. Gynaecol. Oncol. | pmid:19697617 |
| Izawa M et al. | Inhibition of histone deacetylase causes reduction of appressorium formation in the rice blast fungus Magnaporthe oryzae. | 2009 | J. Gen. Appl. Microbiol. | pmid:20118613 |
| Guo W et al. | Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19700647 |
| Yamanaka K et al. | Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos. | 2009 | J. Reprod. Dev. | pmid:19700928 |
| McCulloch MW et al. | Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. | 2009 | Bioorg. Med. Chem. | pmid:19022675 |
| Gao J et al. | Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site. | 2009 | Glia | pmid:19062177 |
| Noh EJ et al. | An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19038231 |
| Kong X et al. | HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. | 2009 | J. Mol. Cell. Cardiol. | pmid:19041327 |
| Rossi M et al. | Caspase cleavage of Itch in chronic lymphocytic leukemia cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19073138 |
| Hostetter CL et al. | Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. | 2009 | Cancer Lett. | pmid:19013015 |
| Heo H et al. | Suppression of caspase-11 expression by histone deacetylase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013432 |
| Giustiniani J et al. | Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53. | 2009 | Cell. Signal. | pmid:19136058 |
| Chen Y et al. | 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. | 2009 | Eur J Med Chem | pmid:19136179 |
| Cowell RM et al. | Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19118529 |
| Wiesen JL and Tomasi TB | Dicer is regulated by cellular stresses and interferons. | 2009 | Mol. Immunol. | pmid:19118902 |
| Togi S et al. | HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19121623 |
| Dje N'Guessan P et al. | Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19122173 |
| Yamada N et al. | Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. | 2009 | Br. J. Cancer | pmid:19127263 |
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| Niu F et al. | Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-kappaB. | 2009 | Brain Res. Bull. | pmid:19103266 |
| Santiago A et al. | Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions. | 2009 | Cell Cycle | pmid:19106612 |
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| Kim HN et al. | Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. | 2009 | Eur. J. Pharmacol. | pmid:19766111 |
| Woodfield GW et al. | Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. | 2009 | Clin. Cancer Res. | pmid:19458056 |
| Hauswald S et al. | Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. | 2009 | Clin. Cancer Res. | pmid:19458058 |
| Arce L et al. | Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. | 2009 | BMC Cancer | pmid:19460168 |
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| Ku WC et al. | Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. | 2009 | Mol. Cell Proteomics | pmid:19505873 |
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| Chang J et al. | The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. | 2009 | J. Cell. Sci. | pmid:19509051 |
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| Takaya T et al. | MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. | 2009 | Circ. J. | pmid:19521018 |
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| Giustiniani J et al. | Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. | 2009 | Exp. Cell Res. | pmid:19632222 |
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| Imesch P et al. | MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. | 2009 | Int. J. Oncol. | pmid:19639184 |
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| Yap OW et al. | Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells. | 2009 | Anticancer Res. | pmid:19331143 |
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| Koh HS et al. | Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells. | 2009 | Mol. Cells | pmid:19937140 |
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| Codd R et al. | Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18725319 |
| Peng DF et al. | DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. | 2009 | Gut | pmid:18664505 |
| Tan HH and Porter AG | p21(WAF1) negatively regulates DNMT1 expression in mammalian cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19275888 |
| Gavin DP et al. | Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. | 2009 | J Psychiatr Res | pmid:19187942 |
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| Gibbs A et al. | Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805354 |
| Popova EY et al. | Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. | 2009 | Chromosome Res. | pmid:19172406 |
| Tsuji Y et al. | The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2009 | Zygote | pmid:19175955 |
| Lee JH et al. | Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. | 2009 | Mol. Cancer Res. | pmid:19808903 |
| Bao Y et al. | Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. | 2009 | Atherosclerosis | pmid:18930459 |
| Chen CZ et al. | The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well. | 2009 | Br. J. Pharmacol. | pmid:19785660 |
| Bonazzi VF et al. | Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma. | 2009 | Genes Chromosomes Cancer | pmid:18803327 |
| Meng CF et al. | Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells. | 2009 | Oncol. Rep. | pmid:19787243 |
| Iljin K et al. | High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. | 2009 | Clin. Cancer Res. | pmid:19789329 |
| Fraczek J et al. | Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. | 2009 | Invest New Drugs | pmid:18825314 |
| Demircan B et al. | Comparative epigenomics of human and mouse mammary tumors. | 2009 | Genes Chromosomes Cancer | pmid:18836996 |
| Lee SH et al. | Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. | 2009 | Oncogene | pmid:18850007 |