trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Chromosome Inversion D007446 1 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Rhabdomyosarcoma, Embryonal D018233 1 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Rhabdoid Tumor D018335 1 associated lipids
Visceral Pain D059265 1 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Rubinstein-Taybi Syndrome D012415 1 associated lipids
Goldenhar Syndrome D006053 1 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Adenomyosis D062788 1 associated lipids
Capsule Opacification D058442 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Cystadenoma, Serous D018293 1 associated lipids
Supratentorial Neoplasms D015173 1 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Hypesthesia D006987 1 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Myopathy, Central Core D020512 1 associated lipids
Roseolovirus Infections D019349 1 associated lipids
Rhabdomyosarcoma, Alveolar D018232 2 associated lipids
Small Cell Lung Carcinoma D055752 2 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
Inflammatory Breast Neoplasms D058922 2 associated lipids
Ganglioneuroma D005729 2 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphoma, Large-Cell, Anaplastic D017728 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
Mastocytoma D034801 3 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Osteomalacia D010018 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Pile LA et al. The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. 2001 Cell. Mol. Life Sci. pmid:11706997
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Klar AJ et al. A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. 2001 Genetics pmid:11404352
Mehra-Chaudhary R et al. Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. 2001 Biochem. J. pmid:11115394
Ferrara FF et al. Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. 2001 Cancer Res. pmid:11196162
Steinbac OC et al. Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in Xenopus. 2000 Sep-Oct Biol. Chem. pmid:11076034
Dressel U et al. Promoter specific sensitivity to inhibition of histone deacetylases: implications for hormonal gene control, cellular differentiation and cancer. 2000 Mar-Apr Anticancer Res. pmid:10810390
Liou JS et al. Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. 2000 J. Biol. Chem. pmid:10967125
Mariadason JM et al. Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. 2000 Cancer Res. pmid:10969808
Gray SG et al. Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. 2000 Int. J. Mol. Med. pmid:10601571
Chen WY and Townes TM Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10618426
Xiao H et al. p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor. 2000 J. Biol. Chem. pmid:10625687
Avram D et al. Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. 2000 J. Biol. Chem. pmid:10744719
Eickhoff B et al. Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. 2000 Biol. Chem. pmid:10746741
Lee SK et al. Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. 2000 J. Biol. Chem. pmid:10777532
Zhang HS et al. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. 2000 Cell pmid:10778858
Fu M et al. p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. 2000 J. Biol. Chem. pmid:10779504
Gays F et al. The mouse tumor cell lines EL4 and RMA display mosaic expression of NK-related and certain other surface molecules and appear to have a common origin. 2000 J. Immunol. pmid:10799866
McInerney JM et al. Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine. 2000 Gene Ther. pmid:10800088
McBlane F and Boyes J Stimulation of V(D)J recombination by histone acetylation. 2000 Curr. Biol. pmid:10801420
Hobbs CA and Gilmour SK High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. 2000 J. Cell. Biochem. pmid:10760944
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Huang X et al. Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. 2000 Clin. Exp. Metastasis pmid:11448064
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Andoh A et al. Modulation of complement component (C3 and factor B) biosynthesis by a histone deacetylase inhibitor in human intestinal epithelial cells. 2000 Int. J. Mol. Med. pmid:10851266
Suzuki T et al. Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. 2000 Int. J. Cancer pmid:11093826
Sutcliffe JE et al. Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription. 2000 Mol. Cell. Biol. pmid:11094071
Magner WJ et al. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. 2000 J. Immunol. pmid:11120829
Damjanovski S et al. Multiple stage-dependent roles for histone deacetylases during amphibian embryogenesis: implications for the involvement of extracellular matrix remodeling. 2000 Int. J. Dev. Biol. pmid:11128570
Liang L et al. Dynamic readjustment of parental methylation patterns of the 5'-flank of the mouse H19 gene during in vitro organogenesis. 2000 Int. J. Dev. Biol. pmid:11128572
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Asoh S et al. The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. 2000 J. Biol. Chem. pmid:10970895
Cong YS and Bacchetti S Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. 2000 J. Biol. Chem. pmid:10986277
Wei LN et al. Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. 2000 J. Biol. Chem. pmid:11006275
Badia E et al. Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling. 2000 Cancer Res. pmid:10945620
Siavoshian S et al. Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. 2000 Gut pmid:10716680
Wharton W et al. Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. 2000 J. Biol. Chem. pmid:10945992
Zhou Q et al. Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. 2000 J. Biol. Chem. pmid:10938272
Xu RH et al. Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction. 2000 Dev. Dyn. pmid:10906781
Gray SG et al. IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. 2000 Cytokine pmid:10880258
Su GH et al. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. 2000 Cancer Res. pmid:10866300
Lin F et al. Unique anti-activator protein-1 activity of retinoic acid receptor beta. 2000 Cancer Res. pmid:10866321
Hemavathy K et al. Human Slug is a repressor that localizes to sites of active transcription. 2000 Mol. Cell. Biol. pmid:10866665
Jin S et al. Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10841572
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Mao C and Shapiro DJ A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. 2000 Endocrinology pmid:10875235
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Kang J et al. Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. 2000 J. Biol. Chem. pmid:10913161
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Carmen AA et al. Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10535926
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List HJ et al. Inhibition of histone deacetylation augments dihydrotestosterone induction of androgen receptor levels: an explanation for trichostatin A effects on androgen-induced chromatin remodeling and transcription of the mouse mammary tumor virus promoter. 1999 Exp. Cell Res. pmid:10527637