Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mogal AP et al. | Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation. | 2007 | J. Biol. Chem. | pmid:17602165 |
Kang JH et al. | Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. | 2007 | Exp. Mol. Med. | pmid:17603295 |
Subramanian C et al. | CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A. | 2007 | Neoplasia | pmid:17603632 |
Chen B and Cepko CL | Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. | 2007 | BMC Dev. Biol. | pmid:17603891 |
Glenisson W et al. | Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. | 2007 | Biochim. Biophys. Acta | pmid:17610967 |
Ehrenkaufer GM et al. | Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. | 2007 | BMC Genomics | pmid:17612405 |
Platta CS et al. | The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. | 2007 | J. Surg. Res. | pmid:17612559 |
Zhang X et al. | Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. | 2007 | Biochem. Cell Biol. | pmid:17612628 |
Shi J et al. | Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis. | 2007 | Cancer Res. | pmid:17616702 |
Perales M and Más P | A functional link between rhythmic changes in chromatin structure and the Arabidopsis biological clock. | 2007 | Plant Cell | pmid:17616736 |
Zhao Y et al. | Roles of histone acetylation modification in basal and inducible expression of hsp26 gene in D. melanogaster. | 2007 | Mol. Cell. Biochem. | pmid:17619947 |
Loudni L et al. | Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17624773 |
Kato N et al. | Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells. | 2007 | Leukemia | pmid:17625602 |
Bu Y and Gelman IH | v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. | 2007 | J. Biol. Chem. | pmid:17626016 |
Dombrowsky H and Uhlig S | Steroids and histone deacetylase in ventilation-induced gene transcription. | 2007 | Eur. Respir. J. | pmid:17626110 |
Zampetaki A et al. | Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17626239 |
Strobl JS et al. | Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. | 2007 | J. Parasitol. | pmid:17626366 |
Ho AK et al. | Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. | 2007 | Endocrinology | pmid:17628002 |
Schneider G et al. | HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. | 2007 | Cell Prolif. | pmid:17635519 |
Bode KA et al. | Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. | 2007 | Immunology | pmid:17635610 |
Imai N et al. | Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. | 2007 | Stem Cells | pmid:17641247 |
Dai B and Rasmussen TP | Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. | 2007 | Stem Cells | pmid:17641388 |
Kaida D et al. | Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. | 2007 | Nat. Chem. Biol. | pmid:17643111 |
Kotake Y et al. | Splicing factor SF3b as a target of the antitumor natural product pladienolide. | 2007 | Nat. Chem. Biol. | pmid:17643112 |
Hishiki T et al. | BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3. | 2007 | J. Biol. Chem. | pmid:17644518 |
Wu Y et al. | Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. | 2007 | Reprod Sci | pmid:17644810 |
Wang CT and Meng M | [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17650409 |
Krämer OH et al. | Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. | 2008 | Oncogene | pmid:17653085 |
Peng Y et al. | The histone deacetylase inhibitor sodium butyrate inhibits baculovirus-mediated transgene expression in Sf9 cells. | 2007 | J. Biotechnol. | pmid:17655959 |
Nair S et al. | Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. | 2008 | Pharm. Res. | pmid:17657594 |
Li YL et al. | [Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. | 2007 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:17659468 |
Wu Y et al. | The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. | 2007 | Genes Cells | pmid:17663720 |
Huber LC et al. | Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. | 2007 | Arthritis Rheum. | pmid:17665426 |
El-Khoury V et al. | The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model. | 2007 | Br. J. Cancer | pmid:17667922 |
Khaw AK et al. | Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells. | 2007 | Mutat. Res. | pmid:17669439 |
Cheli Y et al. | Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. | 2007 Sep-Oct | Biochim. Biophys. Acta | pmid:17669516 |
Gahr S et al. | The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. | 2007 | Int. J. Oncol. | pmid:17671683 |
Tomita A et al. | Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy. | 2007 | Int. J. Hematol. | pmid:17675267 |
Wang J et al. | Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. | 2007 | J. Biol. Chem. | pmid:17675290 |
Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17679169 |
Zhu K et al. | Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. | 2008 | Arch. Gynecol. Obstet. | pmid:17680259 |
Sun DF et al. | [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. | 2007 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:17680526 |
Zhou X et al. | The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. | 2007 | Cancer Genet. Cytogenet. | pmid:17693185 |
Ragno R et al. | Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies. | 2008 | Eur J Med Chem | pmid:17698257 |
Jamaluddin MD et al. | Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. | 2007 | Blood | pmid:17698632 |
Hong S et al. | Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A. | 2007 | Anticancer Drugs | pmid:17704650 |
Byers J and Eichinger D | Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. | 2008 | Int. J. Parasitol. | pmid:17706222 |
Robertson DM et al. | Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium. | 2007 | Exp. Eye Res. | pmid:17709104 |
Chen WY et al. | Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1). | 2007 | Mol. Cell. Biol. | pmid:17709382 |
D'Alessio AC et al. | Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. | 2007 | Mol. Cell. Biol. | pmid:17709385 |
Tsaprouni LG et al. | Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. | 2007 | Clin. Exp. Immunol. | pmid:17711487 |
Yasukawa K et al. | Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts. | 2007 | Br. J. Dermatol. | pmid:17711521 |
Frye M et al. | Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. | 2007 | PLoS ONE | pmid:17712411 |
Adcock IM et al. | Epigenetic regulation of airway inflammation. | 2007 | Curr. Opin. Immunol. | pmid:17720468 |
Zhang Y et al. | Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. | 2007 | Radiat. Res. | pmid:17722998 |
Campanero MR et al. | The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. | 2008 | Oncogene | pmid:17724474 |
Manning J et al. | Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. | 2008 | Immunology | pmid:17725605 |
Ferreira R et al. | Site-specific acetylation of ISWI by GCN5. | 2007 | BMC Mol. Biol. | pmid:17760996 |
Wang F et al. | Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos. | 2007 | Biol. Reprod. | pmid:17823087 |
Kenneth NS et al. | TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17848523 |
Chou SD and Tomasi TB | Spatial distribution of histone methylation during MHC class II expression. | 2008 | Mol. Immunol. | pmid:17850872 |
Terry-Allison T et al. | Relaxed repression of herpes simplex virus type 1 genomes in Murine trigeminal neurons. | 2007 | J. Virol. | pmid:17855552 |
Rao J et al. | Trichostatin-A induces differential changes in histone protein dynamics and expression in HeLa cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17869223 |
Ohoka N et al. | Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. | 2007 | J. Biol. Chem. | pmid:17872950 |
Shivashimpi GM et al. | Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. | 2007 | Bioorg. Med. Chem. | pmid:17881232 |
Zhao TC et al. | Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury. | 2007 | Cardiovasc. Res. | pmid:17884027 |
Pryzbylkowski P et al. | Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. | 2008 | Breast Cancer Res. Treat. | pmid:17891453 |
Wu P et al. | [Role of human telomerase reverse transcriptase in apoptosis of human umbilical vein endothelial cells induced by trichostatin A]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:17892126 |
Akao Y et al. | Downregulation of microRNAs-143 and -145 in B-cell malignancies. | 2007 | Cancer Sci. | pmid:17892514 |
Murga M et al. | Global chromatin compaction limits the strength of the DNA damage response. | 2007 | J. Cell Biol. | pmid:17893239 |
Schnur N et al. | The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. | 2007 | Biochim. Biophys. Acta | pmid:17894944 |
Sichtig N et al. | Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. | 2007 | Arch. Biochem. Biophys. | pmid:17897615 |
Charrier C et al. | Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17897824 |
Nishino N et al. | Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides. | 2008 | Bioorg. Med. Chem. | pmid:17900911 |
Lattal KM et al. | Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. | 2007 | Behav. Neurosci. | pmid:17907845 |
Zhang Y et al. | An epigenetic modifier results in improved in vitro blastocyst production after somatic cell nuclear transfer. | 2007 | Cloning Stem Cells | pmid:17907946 |
Noro R et al. | PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. | 2007 | Int. J. Oncol. | pmid:17912443 |
Hämäläinen M et al. | Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors. | 2008 | Pulm Pharmacol Ther | pmid:17913526 |
Li T and Chiang JY | A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. | 2007 | Gastroenterology | pmid:17920062 |
Tao R et al. | Deacetylase inhibition promotes the generation and function of regulatory T cells. | 2007 | Nat. Med. | pmid:17922010 |
Qi J et al. | [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17923031 |
Pulukuri SM et al. | Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. | 2007 | J. Biol. Chem. | pmid:17923479 |
Itoh Y et al. | Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. | 2007 | J. Med. Chem. | pmid:17929798 |
Pluemsampant S et al. | Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. | 2008 | Int. J. Cancer | pmid:17935135 |
Pourebrahim R et al. | ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations. | 2007 | FEBS Lett. | pmid:17936758 |
Carén H et al. | Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. | 2007 | Br. J. Cancer | pmid:17940511 |
Schauber J et al. | Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. | 2008 | J. Invest. Dermatol. | pmid:17943182 |
Oshima M et al. | Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17949687 |
Kuljaca S et al. | Enhancing the anti-angiogenic action of histone deacetylase inhibitors. | 2007 | Mol. Cancer | pmid:17958916 |
Chen J et al. | Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis. | 2008 | Chem. Biol. Interact. | pmid:17961528 |
Kim EJ et al. | Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. | 2007 | Mol. Cell | pmid:17964266 |
Shen L et al. | Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. | 2007 | PLoS Genet. | pmid:17967063 |
Putnik J et al. | The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60. | 2007 | Biochim. Biophys. Acta | pmid:17980166 |
Su RC et al. | Epigenetic regulation of established human type 1 versus type 2 cytokine responses. | 2008 | J. Allergy Clin. Immunol. | pmid:17980413 |
Stapnes C et al. | Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. | 2007 | Int. J. Oncol. | pmid:17982680 |
Honda H et al. | Regulation of the CLDN3 gene in ovarian cancer cells. | 2007 | Cancer Biol. Ther. | pmid:17986852 |
Renthal W et al. | Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. | 2007 | Neuron | pmid:17988634 |
Gan Y et al. | Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:17996726 |
Ramirez T et al. | Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. | 2008 | Chromosoma | pmid:17999076 |
Malinen M et al. | Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3. | 2008 | Nucleic Acids Res. | pmid:17999998 |