trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Patel V et al. | Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. | 2009 | J. Med. Chem. | pmid:19317450 |
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| Kim HN et al. | Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. | 2009 | Eur. J. Pharmacol. | pmid:19766111 |
| Jonsen MD et al. | The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. | 2009 | Mol. Endocrinol. | pmid:19556346 |
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| Kim W et al. | Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis. | 2009 | Cell Res. | pmid:19436261 |
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| Åuczak MW and JagodziÅ„ski PP | Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells. | 2009 | Biomed. Pharmacother. | pmid:18602794 |
| Kusakabe M et al. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19878646 |
| Auer D et al. | Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer. | 2009 | Breast Cancer Res. Treat. | pmid:18618240 |
| Halaban R et al. | Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. | 2009 | PLoS ONE | pmid:19234609 |
| Maalouf WE et al. | Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term. | 2009 | BMC Dev. Biol. | pmid:19210795 |
| Zhang D et al. | [Synergistic cytotoxicity effect of histone deacetylase inhibitor combined with paclitaxel on lung cancer cell lines and its mechanism]. | 2009 | Ai Zheng | pmid:19958621 |
| Susick L et al. | Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. | 2008 Sep-Oct | J. Cell. Mol. Med. | pmid:18053091 |
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| Kir'ianov GI et al. | [Nucleosome positioning within neomycinphosphotransferase gene (NPTII) on yeast plasmid in repressed and active state]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140324 |
| Miyoshi M et al. | Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells. | 2008 Nov-Dec | Nutrition | pmid:18723323 |
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| Khan AN et al. | Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. | 2008 | Cancer Immunol. Immunother. | pmid:18046553 |
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| Hajji N et al. | Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. | 2008 | Oncogene | pmid:18071312 |
| Walton TJ et al. | DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. | 2008 | Prostate | pmid:18092350 |
| Arany I et al. | Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18094030 |
| Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
| Nasu Y et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. | 2008 | Osteoarthr. Cartil. | pmid:18226559 |
| Wang Q et al. | The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis. | 2008 | Cell Cycle | pmid:18239470 |
| Li X et al. | The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. | 2008 | Cloning Stem Cells | pmid:18241125 |
| Chou SD and Tomasi TB | Spatial distribution of histone methylation during MHC class II expression. | 2008 | Mol. Immunol. | pmid:17850872 |
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| Byers J and Eichinger D | Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. | 2008 | Int. J. Parasitol. | pmid:17706222 |
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| Countryman JK et al. | Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors. | 2008 | J. Virol. | pmid:18337569 |
| Borghol N et al. | Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes. | 2008 | Genomics | pmid:18343090 |
| Lin W et al. | Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. | 2008 | Genes Cells | pmid:18298800 |
| Fan J et al. | ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:18264725 |
| Shi LH et al. | Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. | 2008 | Dev. Dyn. | pmid:18265023 |
| Sasaki K et al. | Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera. | 2008 | Cancer Sci. | pmid:18271940 |
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| Kang JH et al. | CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. | 2008 | J. Cell. Biochem. | pmid:18275041 |
| Oliva J et al. | Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. | 2008 | Exp. Mol. Pathol. | pmid:18280469 |
| Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
| Yu C et al. | Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. | 2008 | Neuro-oncology | pmid:18445700 |
| Yu WP et al. | Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells. | 2008 | Cell Prolif. | pmid:18211287 |
| Jensen TJ et al. | Epigenetic remodeling during arsenical-induced malignant transformation. | 2008 | Carcinogenesis | pmid:18448484 |
| Kikuno N et al. | Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. | 2008 | Int. J. Cancer | pmid:18431742 |
| van West P et al. | Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling. | 2008 | Microbiology (Reading, Engl.) | pmid:18451057 |
| Liu Z et al. | Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells. | 2008 | Oncol. Rep. | pmid:18575731 |
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| Iager AE et al. | Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos. | 2008 | Cloning Stem Cells | pmid:18419249 |
| Liu TC et al. | Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. | 2008 | Mol. Ther. | pmid:18388912 |
| Hayakawa F et al. | Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis. | 2008 | J. Biol. Chem. | pmid:18621739 |
| Reilly CM et al. | The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. | 2008 | J. Autoimmun. | pmid:18650065 |
| Law AY et al. | Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation. | 2008 | Exp. Cell Res. | pmid:18652825 |
| Bosisio D et al. | Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. | 2008 | J. Leukoc. Biol. | pmid:18780875 |
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| Zou XM et al. | Gastric cancer cell lines induced by trichostatin A. | 2008 | World J. Gastroenterol. | pmid:18720545 |
| Duan H et al. | Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. | 2008 | Oncogene | pmid:18695675 |
| Ding X et al. | Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A. | 2008 | Theriogenology | pmid:18556056 |
| Jia J and Chen J | Histone hyperacetylation is involved in the quercetin-induced human leukemia cell death. | 2008 | Pharmazie | pmid:18557424 |
| Narver HL et al. | Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. | 2008 | Ann. Neurol. | pmid:18661558 |
| Yu J et al. | Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. | 2008 | Hepatology | pmid:18666234 |
| Iacobazzi V et al. | Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706393 |
| Liu F et al. | Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. | 2008 | J. Mol. Cell. Cardiol. | pmid:18926829 |
| Gu Z et al. | Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas. | 2008 | Genes Genet. Syst. | pmid:18931460 |
| Wu Y and Guo SW | Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. | 2008 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17376583 |
| Jin B et al. | DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. | 2008 | Hum. Mol. Genet. | pmid:18029387 |
| Gan Y et al. | Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:17996726 |
| Lee EJ et al. | Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. | 2008 | Int. J. Oncol. | pmid:18813790 |
| Van Wagoner DR and Nattel S | Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. | 2008 | J. Mol. Cell. Cardiol. | pmid:18817781 |