trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kitchen MO et al. | Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. | 2015 | Pituitary | pmid:25557289 |
| Duan H et al. | The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. | 2017 | Placenta | pmid:28012453 |
| Zhang HJ et al. | Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. | 2008 | Placenta | pmid:18440631 |
| Munro SK et al. | Histone deacetylase inhibition by trichostatin A mitigates LPS induced TNFα and IL-10 production in human placental explants. | 2013 | Placenta | pmid:23623485 |
| Wang Z et al. | Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. | 2013 | Plant Cell | pmid:23371947 |
| Perales M and Más P | A functional link between rhythmic changes in chromatin structure and the Arabidopsis biological clock. | 2007 | Plant Cell | pmid:17616736 |
| Li H et al. | The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte. | 2014 | Plant Cell | pmid:24464291 |
| Chua YL et al. | The transcriptional enhancer of the pea plastocyanin gene associates with the nuclear matrix and regulates gene expression through histone acetylation. | 2003 | Plant Cell | pmid:12782737 |
| Wang P et al. | Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays. | 2015 | Plant Cell Physiol. | pmid:25670712 |
| Tsuji H et al. | Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice. | 2006 | Plant Cell Physiol. | pmid:16774928 |
| Kojima S et al. | Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. | 2011 | Plant Cell Physiol. | pmid:21700721 |
| Furuta K et al. | The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. | 2011 | Plant Cell Physiol. | pmid:21357580 |
| Eun CH et al. | Activation and epigenetic regulation of DNA transposon nDart1 in rice. | 2012 | Plant Cell Physiol. | pmid:22514089 |
| Jiang F et al. | Trichostatin A increases embryo and green plant regeneration in wheat. | 2017 | Plant Cell Rep. | pmid:28752355 |
| Chua YL et al. | Microarray analysis of chromatin-immunoprecipitated DNA identifies specific regions of tobacco genes associated with acetylated histones. | 2004 | Plant J. | pmid:14996214 |
| Li Y et al. | Histone deacetylation is required for progression through mitosis in tobacco cells. | 2005 | Plant J. | pmid:15659094 |
| Yoshida A et al. | Aberrant spikelet and panicle1, encoding a TOPLESS-related transcriptional co-repressor, is involved in the regulation of meristem fate in rice. | 2012 | Plant J. | pmid:22136599 |
| Farinas B and Mas P | Functional implication of the MYB transcription factor RVE8/LCL5 in the circadian control of histone acetylation. | 2011 | Plant J. | pmid:21205033 |
| Bhat RA et al. | Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. | 2003 | Plant J. | pmid:12581304 |
| Jang IC et al. | Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. | 2003 | Plant J. | pmid:12581311 |
| Tai HH et al. | Dynamic histone acetylation of late embryonic genes during seed germination. | 2005 | Plant Mol. Biol. | pmid:16307366 |
| Tanaka M et al. | The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination. | 2008 | Plant Physiol. | pmid:18024558 |
| Mengel A et al. | Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases. | 2017 | Plant Physiol. | pmid:27980017 |
| Law RD and Suttle JC | Chromatin remodeling in plant cell culture: patterns of DNA methylation and histone H3 and H4 acetylation vary during growth of asynchronous potato cell suspensions. | 2005 | Plant Physiol. Biochem. | pmid:15922608 |
| Pandey P et al. | Dynamics of post-translationally modified histones during barley pollen embryogenesis in the presence or absence of the epi-drug trichostatin A. | 2017 | Plant Reprod | pmid:28526911 |
| Tsuboi H et al. | Epigenetic memory of DNAi associated with cytosine methylation and histone modification in fern. | 2012 | Plant Signal Behav | pmid:22990449 |
| Song Y et al. | Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis. | 2017 | Plant Signal Behav | pmid:29027833 |
| Diao JS et al. | Histone deacetylase inhibitor reduces hypertrophic scarring in a rabbit ear model. | 2013 | Plast. Reconstr. Surg. | pmid:23806955 |
| Paddock MN et al. | The BRCT domain of PARP-1 is required for immunoglobulin gene conversion. | 2010 | PLoS Biol. | pmid:20652015 |
| Hazzalin CA and Mahadevan LC | Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. | 2005 | PLoS Biol. | pmid:16262446 |
| Oksenych V et al. | Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. | 2013 | PLoS Genet. | pmid:23861670 |
| Biacsi R et al. | SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. | 2008 | PLoS Genet. | pmid:18369442 |
| Shen L et al. | Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. | 2007 | PLoS Genet. | pmid:17967063 |
| Appanah R et al. | An unmethylated 3' promoter-proximal region is required for efficient transcription initiation. | 2007 | PLoS Genet. | pmid:17305432 |
| Ukaegbu UE et al. | A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. | 2015 | PLoS Genet. | pmid:25993442 |
| Anderson L et al. | Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni. | 2017 | PLoS Negl Trop Dis | pmid:28406899 |
| Meester-Smoor MA et al. | The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. | 2011 | PLoS ONE | pmid:21949683 |
| Schor IE et al. | Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. | 2012 | PLoS ONE | pmid:23152763 |
| Charni Chaabane S et al. | PDGF-D expression is down-regulated by TGFβ in fibroblasts. | 2014 | PLoS ONE | pmid:25280005 |
| Yang DH et al. | Dynamic rearrangement of F-actin is required to maintain the antitumor effect of trichostatin A. | 2014 | PLoS ONE | pmid:24846135 |
| Gan L et al. | Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. | 2012 | PLoS ONE | pmid:22761896 |
| Zhang F et al. | Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. | 2011 | PLoS ONE | pmid:21346816 |
| Hu Y et al. | Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. | 2011 | PLoS ONE | pmid:21811564 |
| Chachadi VB et al. | Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a. | 2013 | PLoS ONE | pmid:23451223 |
| MacTavish H et al. | Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. | 2010 | PLoS ONE | pmid:21283510 |
| Kuan CS et al. | Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. | 2016 | PLoS ONE | pmid:26807725 |
| Zhang P et al. | Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. | 2015 | PLoS ONE | pmid:26287365 |
| O'Leary DA et al. | Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. | 2009 | PLoS ONE | pmid:20020055 |
| Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
| Chan ST et al. | Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. | 2013 | PLoS ONE | pmid:23342112 |