Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liu X et al. | Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. | 2004 | Biochem. Pharmacol. | pmid:15041467 |
McBain JA et al. | Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. | 1997 | Biochem. Pharmacol. | pmid:9214697 |
Ding BC et al. | Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. | 2001 | Biochem. Pharmacol. | pmid:11266651 |
Xu L et al. | Effect of the histone deacetylase inhibitor trichostatin A on the responsiveness of rat hepatocytes to dioxin. | 1997 | Biochem. Pharmacol. | pmid:9174108 |
Jalonen U et al. | Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. | 2005 | Biochem. Pharmacol. | pmid:15710351 |
Park SJ et al. | Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. | 2009 | Biochem. Pharmacol. | pmid:19426671 |
Brieger A et al. | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | 2004 | Biochem. Pharmacol. | pmid:15183120 |
Kang J et al. | Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. | 2005 | Biochem. Pharmacol. | pmid:15794941 |
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Mehra-Chaudhary R et al. | Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. | 2001 | Biochem. J. | pmid:11115394 |
Avram D et al. | COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. | 2002 | Biochem. J. | pmid:12196208 |
Arts J et al. | Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation. | 1995 | Biochem. J. | pmid:7646441 |
Yang L et al. | An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. | 2003 | Biochem. J. | pmid:12398767 |
Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
Zhang X et al. | Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. | 2007 | Biochem. Cell Biol. | pmid:17612628 |
Sekhavat A et al. | Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. | 2007 | Biochem. Cell Biol. | pmid:18059533 |
Waterborg JH and Kapros T | Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa. | 2002 | Biochem. Cell Biol. | pmid:12123281 |
Ailenberg M and Silverman M | Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604329 |
Higashi T et al. | Histone H2A mobility is regulated by its tails and acetylation of core histone tails. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17445770 |
Gan Y et al. | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16338217 |
Takechi S et al. | Chicken HDAC2 down-regulates IgM light chain gene promoter activity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437980 |
Ailenberg M and Silverman M | Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379227 |
Park KS et al. | Histone modification-mediated Lhx2 gene expression. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23036195 |
Wang X et al. | Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25434997 |
Noh EJ et al. | An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19038231 |
Ishimaru N et al. | Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20188708 |
Steiner E et al. | SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047174 |
Rossi M et al. | Caspase cleavage of Itch in chronic lymphocytic leukemia cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19073138 |
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Harada Y et al. | A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11396961 |
Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
Matsubara K et al. | Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23567968 |
Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
Sobue S et al. | Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27687545 |
Carambula SF et al. | Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19665989 |
Hejnar J et al. | Demethylation of host-cell DNA at the site of avian retrovirus integration. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14623319 |
Brglez V et al. | Secreted phospholipases Aâ‚‚are differentially expressed and epigenetically silenced in human breast cancer cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24508801 |
Hasegawa T et al. | Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10066455 |
Inokoshi J et al. | Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079191 |
Park PH et al. | Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12804592 |
Oshima M et al. | Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17949687 |
Choi JH et al. | TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19914212 |
Iacobazzi V et al. | Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706393 |
Shi H et al. | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23201405 |
Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |
Hashii M et al. | Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17367762 |