Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Oliveira CS et al. | Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos. | 2010 | Reprod. Fertil. Dev. | pmid:20591338 |
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Xia J et al. | Epigenetic modification of vomeronasal (V2r) precursor neurons by histone deacetylation. | 2010 | Neuroscience | pmid:20594945 |
Tian F et al. | Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons. | 2010 | Ann. N. Y. Acad. Sci. | pmid:20633124 |
Rössler R et al. | Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons. | 2010 | Neuroscience | pmid:20643196 |
Rahman R et al. | Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high-grade childhood brain tumor cells. | 2010 | Mol. Cancer Ther. | pmid:20643785 |
Tong JH et al. | Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. | 2010 | BMC Cancer | pmid:20525238 |
Han DS et al. | Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways. | 2010 | J. Cell. Biochem. | pmid:20568119 |
Sudo H and Baas PW | Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. | 2010 | J. Neurosci. | pmid:20505088 |
Yoshizawa Y et al. | Impaired active demethylation of the paternal genome in pronuclear-stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection. | 2010 | Mol. Reprod. Dev. | pmid:19743475 |
Bui HT et al. | Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos. | 2010 | Biol. Reprod. | pmid:20505166 |
Kim IA et al. | HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? | 2010 | J. Radiat. Res. | pmid:20505264 |
Chen J et al. | Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes. | 2010 | Epigenetics | pmid:20505343 |
Liu YW et al. | Inhibition of LPS-induced C/EBP delta by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells. | 2010 | J. Cell. Biochem. | pmid:20506344 |
Kitamoto S et al. | Promoter hypomethylation contributes to the expression of MUC3A in cancer cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20510874 |
Liang Q et al. | The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. | 2010 | Int. J. Cancer | pmid:20112338 |
Beedanagari SR et al. | Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. | 2010 | Toxicol. Lett. | pmid:20116417 |
Lu Y et al. | Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. | 2010 | Hum. Reprod. | pmid:20118114 |
Davies GF et al. | Troglitazone inhibits histone deacetylase activity in breast cancer cells. | 2010 | Cancer Lett. | pmid:19699029 |
Hajji N et al. | Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. | 2010 | Oncogene | pmid:20118981 |
Suh HS et al. | Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. | 2010 | J Neuroimmune Pharmacol | pmid:20157787 |
Crosson CE et al. | Inhibition of histone deacetylase protects the retina from ischemic injury. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20164449 |
Jang ER et al. | ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response. | 2010 | Exp. Mol. Med. | pmid:20164679 |
Desai D et al. | SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20167479 |
Zhao J et al. | Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. | 2010 | Cell Reprogram | pmid:20132015 |
Chuang C et al. | Acetylation of RNA processing proteins and cell cycle proteins in mitosis. | 2010 | J. Proteome Res. | pmid:20812760 |
Martinez-Diaz MA et al. | Pre- and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases. | 2010 | Cell Reprogram | pmid:20132016 |
Yang F et al. | Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize. | 2010 | BMC Plant Biol. | pmid:20718950 |
Host L et al. | Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. | 2010 | J. Neurochem. | pmid:20132486 |
Wu Y et al. | Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. | 2010 | BMC Cancer | pmid:20132554 |
Kim TH et al. | The histone deacetylase inhibitor, trichostatin A, inhibits the development of 2,4-dinitrofluorobenzene-induced dermatitis in NC/Nga mice. | 2010 | Int. Immunopharmacol. | pmid:20728595 |
Aoyama M et al. | Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. | 2010 | Nutrition | pmid:20004081 |
Ji P et al. | Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. | 2010 | Haematologica | pmid:20823130 |
Nunes MJ et al. | Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription. | 2010 | J. Neurochem. | pmid:20096088 |
Weng YI et al. | Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20678512 |
Aizawa S and Yamamuro Y | Involvement of histone acetylation in the regulation of choline acetyltransferase gene in NG108-15 neuronal cells. | 2010 | Neurochem. Int. | pmid:20100532 |
Tamannai M et al. | The inhibitor of growth 1 (ING1) is involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells. | 2010 | Oncol. Res. | pmid:20681406 |
Wu J et al. | Trichostatin A sensitizes cisplatin-resistant A549 cells to apoptosis by up-regulating death-associated protein kinase. | 2010 | Acta Pharmacol. Sin. | pmid:20048748 |
Sonnemann J et al. | Serine proteases in histone deacetylase inhibitor-induced apoptosis. | 2010 | Mol. Cancer Ther. | pmid:20682651 |
Hebbel RP et al. | The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. | 2010 | Blood | pmid:20053759 |
Fu J et al. | Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase. | 2010 | Bioorg. Med. Chem. | pmid:21067930 |
He R et al. | Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents. | 2010 | J. Med. Chem. | pmid:20055418 |
Nicodeme E et al. | Suppression of inflammation by a synthetic histone mimic. | 2010 | Nature | pmid:21068722 |
Ajiro K et al. | Reciprocal epigenetic modification of histone H2B occurs in chromatin during apoptosis in vitro and in vivo. | 2010 | Cell Death Differ. | pmid:20057502 |
Auzzas L et al. | Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. | 2010 | J. Med. Chem. | pmid:21073160 |
Choi YS et al. | Differentiation of human adipose-derived stem cells into beating cardiomyocytes. | 2010 | J. Cell. Mol. Med. | pmid:20070436 |
Lee KJ et al. | Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. | 2010 | Biochim. Biophys. Acta | pmid:20080132 |
Grabiec AM et al. | Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. | 2010 | J. Immunol. | pmid:20100935 |
Chatterjee A et al. | An efficient synthesis of (+/-)-trichostatic Acid and analogues: a new route to (+/-)-trichostatin A. | 2010 | Org. Lett. | pmid:20104892 |
Xu J et al. | CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors. | 2010 | Breast Cancer Res. Treat. | pmid:19466541 |
Li Y et al. | Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. | 2010 | Mol. Cancer | pmid:20946668 |
Gupta PK et al. | Inhibitors selective for HDAC6 in enzymes and cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20947351 |
Tian F et al. | NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons. | 2010 | Amino Acids | pmid:19565326 |
Watson JA et al. | Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. | 2010 | J. Cell. Mol. Med. | pmid:19583812 |
Song S et al. | Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1. | 2010 | Cardiovasc. Res. | pmid:19633316 |
Eskeland R et al. | Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes. | 2010 | Cold Spring Harb. Symp. Quant. Biol. | pmid:21502416 |
Liu YL et al. | Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma. | 2010 | Autophagy | pmid:20962572 |
McKenzie L et al. | p53-dependent repression of polo-like kinase-1 (PLK1). | 2010 | Cell Cycle | pmid:20962589 |
Mittal MK et al. | Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. | 2010 | Mol. Biol. Rep. | pmid:19277896 |
Zein S et al. | Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20975082 |
Chao KC et al. | Anti-tumor activity of histone deacetylase inhibitors and the effect on ATP-binding cassette in ovarian carcinoma cells. | 2010 | Eur. J. Gynaecol. Oncol. | pmid:20882882 |
Lee CS et al. | 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. | 2010 | Eur. J. Pharmacol. | pmid:20868669 |
Yuan GB et al. | Combined effects of all-trans-retinoic acid and trichostatin A on the induction of differentiation of thyroid carcinoma cells. | 2010 | Chin J Cancer | pmid:20346212 |
Wang QH et al. | Opposite effects of Trichostatin A on activation of mast cells by different stimulants. | 2010 | FEBS Lett. | pmid:20371366 |
Simboeck E et al. | A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors. | 2010 | J. Biol. Chem. | pmid:20952396 |
Robertson DM et al. | C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20375332 |
Halili MA et al. | Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. | 2010 | J. Leukoc. Biol. | pmid:20200406 |
Karagiannis TC et al. | Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes. | 2010 | Aging (Albany NY) | pmid:20930262 |
Reichrath S et al. | Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206691 |
Milagre I et al. | Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. | 2010 | J. Alzheimers Dis. | pmid:20930312 |
Bertrand P | Inside HDAC with HDAC inhibitors. | 2010 | Eur J Med Chem | pmid:20223566 |
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Majid S et al. | Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer. | 2010 | Cancer Res. | pmid:20332239 |
Khobta A et al. | Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. | 2010 | Nucleic Acids Res. | pmid:20338881 |
Spin JM et al. | Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. | 2010 | PLoS ONE | pmid:21179216 |
Marumo T et al. | Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19906951 |
Yakovlev A et al. | Epigenetic regulation of caspase-3 gene expression in rat brain development. | 2010 | Gene | pmid:19909801 |
Freidkin I et al. | Effects of histone deacetylase inhibitors on rat mesangial cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19923417 |
Perisic T et al. | Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes. | 2010 | Neuropsychopharmacology | pmid:19924110 |
Kitano A et al. | Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface. | 2010 | Mol. Vis. | pmid:21203344 |
Sponziello M et al. | Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. | 2010 | J. Endocrinol. Invest. | pmid:19794300 |
Himaki T et al. | Effects of trichostatin A on in vitro development and transgene function in somatic cell nuclear transfer embryos derived from transgenic Clawn miniature pig cells. | 2010 | Anim. Sci. J. | pmid:20887307 |
Wu P et al. | Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells. | 2010 | Cell Death Differ. | pmid:19798105 |
Peidis P et al. | HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2. | 2010 | Aging (Albany NY) | pmid:21076179 |
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Li X et al. | Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. | 2010 | Br. J. Haematol. | pmid:19807731 |
Ninios YP et al. | Differential sensitivity of human leukemic cell lines to the histone deacetylase inhibitor, trichostatin A. | 2010 | Leuk. Res. | pmid:19782399 |
Higashiyama R et al. | Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. | 2010 | Mod Rheumatol | pmid:19784544 |
Law AY and Wong CK | Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. | 2010 | Exp. Cell Res. | pmid:19786016 |
Estiu G et al. | On the inhibition of histone deacetylase 8. | 2010 | Bioorg. Med. Chem. | pmid:20472442 |
Kobori A et al. | Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines. | 2010 | World J. Gastroenterol. | pmid:20480520 |