Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Srirattana K et al. | Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22578161 |
Truong M et al. | Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence. | 2012 | Br. J. Cancer | pmid:22596233 |
Hsu DW et al. | Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. | 2012 | Nucleic Acids Res. | pmid:22600736 |
Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
Kang FW et al. | Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. | 2012 | Oncol. Rep. | pmid:22552321 |
Meng J et al. | The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. | 2012 | Oncol. Rep. | pmid:22552631 |
Hsieh TH et al. | Phthalates stimulate the epithelial to mesenchymal transition through an HDAC6-dependent mechanism in human breast epithelial stem cells. | 2012 | Toxicol. Sci. | pmid:22552774 |
Balsas P et al. | Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. | 2012 | Leuk. Res. | pmid:21978467 |
Deckmann K et al. | Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. | 2012 | Cell. Signal. | pmid:21983014 |
Hoque MA et al. | Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23021104 |
Zhang L et al. | Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts. | 2012 | J. Biol. Chem. | pmid:23024362 |
Merschbaecher K et al. | Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation. | 2012 | PLoS ONE | pmid:23028801 |
Zhao ZN et al. | TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC. | 2012 | PLoS ONE | pmid:23028803 |
Banik D et al. | Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. | 2012 | PLoS ONE | pmid:23028998 |
Bergman JA et al. | Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. | 2012 | J. Med. Chem. | pmid:23009203 |
Vaidya AS et al. | Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23010266 |
Shi YL et al. | Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. | 2012 | J. Dermatol. Sci. | pmid:22999682 |
Tomosugi M et al. | Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. | 2012 | Cancer Sci. | pmid:22957647 |
Miyagawa K et al. | Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice. | 2012 | Behav. Brain Res. | pmid:22963996 |
Liu N et al. | Histone deacetylase inhibitors inducing human cervical cancer cell apoptosis by decreasing DNA-methyltransferase 3B. | 2012 | Chin. Med. J. | pmid:22964322 |
Brown RE et al. | Superinduction of leptin mRNA in mouse hypothalamic neurons. | 2012 | Neuroreport | pmid:22964970 |
Conway GD et al. | Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation. | 2012 | Glia | pmid:22927334 |
Sancho-Pelluz J and Paquet-Durand F | HDAC inhibition prevents Rd1 mouse photoreceptor degeneration. | 2012 | Adv. Exp. Med. Biol. | pmid:22183322 |
Chen H et al. | LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. | 2012 | Cancer Lett. | pmid:22743615 |
Vadnal J et al. | Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. | 2012 | Exp Brain Res | pmid:22811216 |
Lin KT et al. | HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. | 2012 | Clin. Cancer Res. | pmid:22811583 |
He Q et al. | Characterization of an apical ceramide-enriched compartment regulating ciliogenesis. | 2012 | Mol. Biol. Cell | pmid:22718902 |
Balmer NV et al. | Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. | 2012 | Hum. Mol. Genet. | pmid:22723015 |
Oh HJ et al. | Trichostatin a improves preimplantation development of bovine cloned embryos and alters expression of epigenetic and pluripotency genes in cloned blastocysts. | 2012 | J. Vet. Med. Sci. | pmid:22785124 |
Zhang HN et al. | Endogenous glucocorticoids inhibit myocardial inflammation induced by lipopolysaccharide: involvement of regulation of histone deacetylation. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22472906 |
Qin ZX et al. | [Effect of TSA and VPA treatment on long-tailed macaque (Macaca fascicularis)-pig interspecies somatic cell nuclear transfer]. | 2012 | Yi Chuan | pmid:22425953 |
Zhou X et al. | Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22425986 |
Fleiss B et al. | Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. | 2012 | J Neuroinflammation | pmid:22512781 |
Eun CH et al. | Activation and epigenetic regulation of DNA transposon nDart1 in rice. | 2012 | Plant Cell Physiol. | pmid:22514089 |
Ching LY et al. | Synergistic effect of p53 on TSA-induced stanniocalcin 1 expression in human nasopharyngeal carcinoma cells, CNE2. | 2012 | J. Mol. Endocrinol. | pmid:22493143 |
Yoshida A et al. | Aberrant spikelet and panicle1, encoding a TOPLESS-related transcriptional co-repressor, is involved in the regulation of meristem fate in rice. | 2012 | Plant J. | pmid:22136599 |
Shen T et al. | Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22138223 |
Rossi LE et al. | Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. | 2012 | J. Leukoc. Biol. | pmid:22124136 |
Landreville S et al. | Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. | 2012 | Clin. Cancer Res. | pmid:22038994 |
Andrews KT et al. | Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. | 2012 | PLoS ONE | pmid:22384084 |
Zhu S et al. | TSA-induced JMJD2B downregulation is associated with cyclin B1-dependent survivin degradation and apoptosis in LNCap cells. | 2012 | J. Cell. Biochem. | pmid:22388778 |
Usui T et al. | HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22389387 |
Wang H et al. | Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells. | 2012 | J Neural Transm | pmid:22407380 |
Yang PM et al. | CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1. | 2012 | Epigenetics | pmid:22419072 |
Colussi C et al. | P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22859492 |
Serrat N et al. | Deacetylation of C/EBPβ is required for IL-4-induced arginase-1 expression in murine macrophages. | 2012 | Eur. J. Immunol. | pmid:22865229 |
Fan LX et al. | Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. | 2012 | Kidney Int. | pmid:21900881 |
Zhu L et al. | Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. | 2012 | Pediatr. Pulmonol. | pmid:21905265 |
Pufahl L et al. | Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. | 2012 | J. Cell. Mol. Med. | pmid:21883892 |
Wang C et al. | Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. | 2012 | Diabetes Metab. Res. Rev. | pmid:22228707 |