trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hosseinkhani M et al. | Trichostatin A induces myocardial differentiation of monkey ES cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17368572 |
| Kim HJ et al. | Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371805 |
| Kitamura H et al. | Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition. | 2007 | J. Urol. | pmid:17574613 |
| Vecsey CG et al. | Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. | 2007 | J. Neurosci. | pmid:17553985 |
| Pinnoji RC et al. | Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. | 2007 | Virol. J. | pmid:17555596 |
| Kishigami S et al. | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. | 2007 | J. Reprod. Dev. | pmid:17077581 |
| Khan Z et al. | HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. | 2007 | Exp. Cell Res. | pmid:17555745 |
| Donadelli M et al. | Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. | 2007 | Biochim. Biophys. Acta | pmid:17555830 |
| Smetana K et al. | Effect of histone deacetylase inhibitors on the cell nucleus and nucleolus of leukemic myeloblasts in vitro - a cytochemical study. | 2007 | Acta Histochem. | pmid:17559910 |
| Ye J et al. | De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists. | 2007 | J. Virol. | pmid:17596302 |
| Cantor JP et al. | Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. | 2007 | Int. J. Cancer | pmid:17019711 |
| Kim SH et al. | Regulation of the HIF-1alpha stability by histone deacetylases. | 2007 | Oncol. Rep. | pmid:17273746 |
| Ou JN et al. | Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. | 2007 | Biochem. Pharmacol. | pmid:17276411 |
| Hatjiharissi E et al. | Proteomic analysis of waldenstrom macroglobulinemia. | 2007 | Cancer Res. | pmid:17440091 |
| Cecconi D et al. | Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. | 2007 | Proteomics | pmid:17443844 |
| Higashi T et al. | Histone H2A mobility is regulated by its tails and acetylation of core histone tails. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17445770 |
| Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
| Hellebrekers DM et al. | Identification of epigenetically silenced genes in tumor endothelial cells. | 2007 | Cancer Res. | pmid:17483324 |
| Yi T et al. | Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis. | 2007 | Exp. Mol. Med. | pmid:17464183 |
| Long JE and Cai X | Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle. | 2007 | Gene | pmid:17150312 |
| Wong CM et al. | Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. | 2007 | Hepatology | pmid:17464989 |
| Chen Y et al. | Homeobox gene HOP has a potential tumor suppressive activity in human lung cancer. | 2007 | Int. J. Cancer | pmid:17417779 |
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| Hwang CK et al. | Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. | 2007 | Mol. Cell. Biol. | pmid:17452465 |
| Piotrowska H and Jagodzinski PP | Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. | 2007 | Biomed. Pharmacother. | pmid:17498915 |
| Berg T et al. | Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. | 2007 | Leuk. Res. | pmid:17056112 |
| Iliopoulos D et al. | Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. | 2007 | Ann. Rheum. Dis. | pmid:17502362 |
| Sato N et al. | RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. | 2007 | Int. J. Cancer | pmid:17096327 |
| Vikhanskaya F et al. | Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53. | 2007 | Nucleic Acids Res. | pmid:17344317 |
| Zhang R et al. | HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. | 2007 | Mol. Cell. Biol. | pmid:17101789 |
| Krennhrubec K et al. | Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17346959 |
| Vincent A et al. | Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells. | 2007 | Oncogene | pmid:17471237 |
| Jung EJ et al. | Lytic induction and apoptosis of Epstein-Barr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir. | 2007 | Cancer Lett. | pmid:16647201 |
| Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17679169 |
| Sun DF et al. | [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. | 2007 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:17680526 |
| Peng Y et al. | The histone deacetylase inhibitor sodium butyrate inhibits baculovirus-mediated transgene expression in Sf9 cells. | 2007 | J. Biotechnol. | pmid:17655959 |
| Li YL et al. | [Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. | 2007 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:17659468 |
| Wu Y et al. | The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. | 2007 | Genes Cells | pmid:17663720 |
| Schneider G et al. | HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. | 2007 | Cell Prolif. | pmid:17635519 |
| Bode KA et al. | Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. | 2007 | Immunology | pmid:17635610 |
| Imai N et al. | Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. | 2007 | Stem Cells | pmid:17641247 |
| Dai B and Rasmussen TP | Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. | 2007 | Stem Cells | pmid:17641388 |
| Kaida D et al. | Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. | 2007 | Nat. Chem. Biol. | pmid:17643111 |
| Kotake Y et al. | Splicing factor SF3b as a target of the antitumor natural product pladienolide. | 2007 | Nat. Chem. Biol. | pmid:17643112 |
| Kang JH et al. | Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. | 2007 | Exp. Mol. Med. | pmid:17603295 |
| Subramanian C et al. | CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A. | 2007 | Neoplasia | pmid:17603632 |
| Chen B and Cepko CL | Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. | 2007 | BMC Dev. Biol. | pmid:17603891 |
| Wu Y et al. | Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. | 2007 | Reprod Sci | pmid:17644810 |
| Wang CT and Meng M | [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17650409 |
| Janowski BA et al. | Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. | 2007 | Nat. Chem. Biol. | pmid:17259978 |
| Oyama T et al. | Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. | 2007 | J. Cell Biol. | pmid:17261849 |
| Zhang L et al. | Small molecule regulators of autophagy identified by an image-based high-throughput screen. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18024584 |
| Woo HJ et al. | Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells. | 2007 | Exp. Mol. Pathol. | pmid:16574101 |
| Park JJ et al. | Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. | 2007 | J. Gen. Virol. | pmid:18024889 |
| Moiseeva EP et al. | Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. | 2007 | Mol. Cancer Ther. | pmid:18025290 |
| Brest P et al. | Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. | 2007 | Cancer Res. | pmid:18056459 |
| Sourlingas TG et al. | Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. | 2007 | Ann. N. Y. Acad. Sci. | pmid:18056955 |
| Sekhavat A et al. | Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. | 2007 | Biochem. Cell Biol. | pmid:18059533 |
| Seo H et al. | Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation, and its application to antibody engineering. | 2007 | Biotechnol. Genet. Eng. Rev. | pmid:18059633 |
| Januchowski R et al. | Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. | 2007 | Cancer Lett. | pmid:16624484 |
| Araki H et al. | Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. | 2007 | Blood | pmid:17185465 |
| Mazzarelli P et al. | Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? | 2007 | Cancer Biol. Ther. | pmid:18253084 |
| Lee EL et al. | Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. | 2007 | J. Cell. Physiol. | pmid:17186499 |
| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Feng W et al. | Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. | 2007 | Int. J. Cancer | pmid:17230502 |
| Wu ZQ et al. | Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. | 2007 | Chin. Med. J. | pmid:18167185 |
| Karam JA et al. | The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. | 2007 | Int. J. Cancer | pmid:17230511 |
| Ghosh AK et al. | Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17234156 |
| Shimazu T et al. | Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. | 2007 | J. Biol. Chem. | pmid:17172643 |
| Januchowski R and Jagodzinski PP | Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. | 2007 | Int. Immunopharmacol. | pmid:17178387 |
| Cras A et al. | Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. | 2007 | Oncogene | pmid:17213810 |
| Karagiannis TC et al. | Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments. | 2007 | Oncogene | pmid:17213813 |
| Elaut G et al. | A metabolic screening study of trichostatin A (TSA) and TSA-like histone deacetylase inhibitors in rat and human primary hepatocyte cultures. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17218485 |
| Frye M et al. | Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. | 2007 | PLoS ONE | pmid:17712411 |
| Adcock IM et al. | Epigenetic regulation of airway inflammation. | 2007 | Curr. Opin. Immunol. | pmid:17720468 |
| Zhang Y et al. | Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. | 2007 | Radiat. Res. | pmid:17722998 |
| Zhou X et al. | The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. | 2007 | Cancer Genet. Cytogenet. | pmid:17693185 |
| Zhong S et al. | Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. | 2007 | Oncogene | pmid:17043644 |
| Wang F et al. | Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos. | 2007 | Biol. Reprod. | pmid:17823087 |
| Katz RA et al. | High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. | 2007 | J. Virol. | pmid:17202206 |
| De los Santos M et al. | Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. | 2007 | Mol. Cancer Ther. | pmid:17431121 |
| Qi J et al. | [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18396643 |
| Yang H et al. | Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16973938 |
| Sichtig N et al. | Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. | 2007 | Arch. Biochem. Biophys. | pmid:17897615 |
| Charrier C et al. | Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17897824 |
| Li T and Chiang JY | A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. | 2007 | Gastroenterology | pmid:17920062 |
| Tao R et al. | Deacetylase inhibition promotes the generation and function of regulatory T cells. | 2007 | Nat. Med. | pmid:17922010 |
| Qi J et al. | [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17923031 |
| Pulukuri SM et al. | Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. | 2007 | J. Biol. Chem. | pmid:17923479 |
| Stapnes C et al. | Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. | 2007 | Int. J. Oncol. | pmid:17982680 |
| Honda H et al. | Regulation of the CLDN3 gene in ovarian cancer cells. | 2007 | Cancer Biol. Ther. | pmid:17986852 |
| Renthal W et al. | Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. | 2007 | Neuron | pmid:17988634 |
| Carén H et al. | Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. | 2007 | Br. J. Cancer | pmid:17940511 |
| Kim EJ et al. | Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. | 2007 | Mol. Cell | pmid:17964266 |
| Barr H et al. | Mbd2 contributes to DNA methylation-directed repression of the Xist gene. | 2007 | Mol. Cell. Biol. | pmid:17353271 |
| Li B et al. | FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17360565 |
| Vandergeeten C et al. | HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha + TSA. | 2007 | Biochem. Pharmacol. | pmid:17386923 |
| Rohner A et al. | Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis. | 2007 | Leuk. Res. | pmid:17391757 |
| Dompierre JP et al. | Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. | 2007 | J. Neurosci. | pmid:17392473 |
| Hashii M et al. | Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17367762 |