Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chawalit S et al. | Trichostatin A and ascorbic acid assist in the development of porcine handmade cloned embryos via different physiologic pathways. | 2012 | Reprod Sci | pmid:22534331 |
Jichan Nie SW et al. | Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent. | 2010 | Reprod Sci | pmid:20697142 |
Wu Y et al. | Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. | 2007 | Reprod Sci | pmid:17644810 |
Poljak M et al. | Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells. | 2014 | Reprod Sci | pmid:24429678 |
Seo SK et al. | Trichostatin A Induces NAG-1 Expression and Apoptosis in Human Endometriotic Stromal Cells. | 2018 | Reprod Sci | pmid:29157123 |
Karolczak-Bayatti M et al. | Expression of the GTP-binding protein Gαs in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A. | 2012 | Reprod Sci | pmid:22875848 |
Oliveira CS et al. | Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos. | 2010 | Reprod. Fertil. Dev. | pmid:20591338 |
Song BS et al. | Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. | 2014 | Reprod. Fertil. Dev. | pmid:23506644 |
Jin YX et al. | Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro. | 2014 | Reprod. Fertil. Dev. | pmid:23759302 |
Saini M et al. | Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. | 2016 | Reprod. Fertil. Dev. | pmid:25409339 |
Di Renzo F et al. | VPA-related axial skeletal defects and apoptosis: a proposed event cascade. | 2010 | Reprod. Toxicol. | pmid:19850124 |
Endo T et al. | Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes. | 2006 | Reproduction | pmid:16514187 |
Oliveira CS et al. | HDAC inhibition decreases XIST expression on female IVP bovine blastocysts. | 2013 | Reproduction | pmid:23104973 |
Kerr JB et al. | The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. | 2012 | Reproduction | pmid:22301887 |
Liao HF et al. | Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. | 2015 | Reproduction | pmid:26159833 |
Wee G et al. | Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos. | 2007 | Reproduction | pmid:18042635 |
Bui HT et al. | Regulation of chromatin and chromosome morphology by histone H3 modifications in pig oocytes. | 2007 | Reproduction | pmid:17307905 |
Bodas M et al. | Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses. | 2018 | Respir. Res. | pmid:29301535 |
Chen J et al. | E1A has no effect on LPS-induced IL-6 secretion in rat alveolar epithelial cells. | 2009 | Respiration | pmid:19299891 |
Zhang HP et al. | Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation. | 2016 | Respirology | pmid:26991676 |
Chen WP et al. | Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. | 2011 | Rheumatol. Int. | pmid:20390279 |
Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
Ohnishi K | [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | 2006 | Rinsho Ketsueki | pmid:16986710 |
Katsuno M et al. | [Dysfunction of dynactin 1 in motor neuron degeneration]. | 2013 | Rinsho Shinkeigaku | pmid:24291886 |
Vadie N et al. | MYCNOS functions as an antisense RNA regulating MYCN. | 2015 | RNA Biol | pmid:26156430 |
Gavin DP et al. | Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. | 2008 | Schizophr. Res. | pmid:18539439 |
Inoue K et al. | Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. | 2015 | Sci Rep | pmid:25974394 |
Rong X et al. | Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. | 2016 | Sci Rep | pmid:27703255 |
Liu J et al. | Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. | 2013 | Sci Rep | pmid:23378917 |
Cai MH et al. | Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine. | 2018 | Sci Rep | pmid:29374219 |
Ikeda K et al. | In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model. | 2017 | Sci Rep | pmid:28300163 |
Gupta DK et al. | DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. | 2016 | Sci Rep | pmid:27033103 |
Deguise MO et al. | Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. | 2016 | Sci Rep | pmid:27349908 |
Svegliati S et al. | Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. | 2014 | Sci Signal | pmid:25185156 |
Cheutin T et al. | Maintenance of stable heterochromatin domains by dynamic HP1 binding. | 2003 | Science | pmid:12560555 |
Chen Lf W et al. | Duration of nuclear NF-kappaB action regulated by reversible acetylation. | 2001 | Science | pmid:11533489 |
Nambu Y et al. | Transcription-coupled events associating with immunoglobulin switch region chromatin. | 2003 | Science | pmid:14684824 |
Wang H et al. | Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. | 2001 | Science | pmid:11387442 |
Baur JA et al. | Telomere position effect in human cells. | 2001 | Science | pmid:11408657 |
Taunton J et al. | A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. | 1996 | Science | pmid:8602529 |
Bakin AV and Curran T | Role of DNA 5-methylcytosine transferase in cell transformation by fos. | 1999 | Science | pmid:9888853 |
Hall IM et al. | Establishment and maintenance of a heterochromatin domain. | 2002 | Science | pmid:12215653 |
Jung J and Bonini N | CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. | 2007 | Science | pmid:17332375 |
Jia S et al. | RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. | 2004 | Science | pmid:15218150 |
Hu XL et al. | [Effects of trichostatin A on the expressions of inflammatory cytokines and toll-like receptor 4 and the acetylation of nuclear factor-κB induced by lipopolysaccharide in macrophage]. | 2012 | Sheng Li Xue Bao | pmid:23258328 |
Shao G et al. | [Effect of monoamine oxidase inhibitor on the differentiation of malignant glioma cell]. | 2012 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:22826952 |
Chen YT et al. | Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. | 2011 | Spine | pmid:21343850 |
Dhoke NR et al. | Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. | 2016 | Stem Cell Res | pmid:27394013 |
Majumder A et al. | Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors. | 2013 | Stem Cell Res | pmid:23644509 |
Kong Q et al. | Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer. | 2014 | Stem Cell Rev | pmid:24510582 |
Imai N et al. | Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. | 2007 | Stem Cells | pmid:17641247 |
Dai B and Rasmussen TP | Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. | 2007 | Stem Cells | pmid:17641388 |
Ruau D et al. | Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. | 2008 | Stem Cells | pmid:18203677 |
Han DW et al. | Epigenetic hierarchy governing Nestin expression. | 2009 | Stem Cells | pmid:19415779 |
Fan Y et al. | Derivation of cloned human blastocysts by histone deacetylase inhibitor treatment after somatic cell nuclear transfer with β-thalassemia fibroblasts. | 2011 | Stem Cells Dev. | pmid:21322785 |
Jiao F et al. | Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. | 2013 | Stem Cells Dev. | pmid:23750509 |
Hu X et al. | Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner. | 2013 | Stem Cells Dev. | pmid:22873791 |
Erb TM et al. | Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. | 2011 | Stem Cells Dev. | pmid:21204619 |
Lim SY et al. | Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. | 2013 | Stem Cells Transl Med | pmid:23884641 |
Hansberg-Pastor V et al. | The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. | 2013 | Steroids | pmid:23474171 |
Lin T et al. | Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver. | 2007 | Surgery | pmid:17560255 |
Zarnegar R et al. | Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. | 2002 | Surgery | pmid:12490845 |
Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
Mitmaker EJ et al. | Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors. | 2011 | Surgery | pmid:21193210 |
Awe S and Renkawitz-Pohl R | Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster. | 2010 | Syst Biol Reprod Med | pmid:20170286 |
[Isolation of drug-resistant mutant cells]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1745788 | |
Yoshida M and Horinouchi S | [Histone deacetylase inhibitors--new anticancer agents?]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10771678 |
Yoshida M and Beppu T | [Trichostatins and leptomycins, new cell cycle inhibitors specific for G1 and G2 phases]. | 1989 | Tanpakushitsu Kakusan Koso | pmid:2678278 |
Shimazu T et al. | [Biological diversity of protein lysine acetylation which has been revealed by small molecule inhibitors]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051411 |
Yoshida M | [Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051427 |
Yoshida M | [Molecular targets of cell cycle inhibitors and their mode of action]. | 1996 | Tanpakushitsu Kakusan Koso | pmid:8890633 |
Cervera RP et al. | Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. | 2009 | Theriogenology | pmid:19765811 |
Chen CH et al. | Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos. | 2013 | Theriogenology | pmid:23566670 |
Lee HS et al. | Enhanced histone acetylation in somatic cells induced by a histone deacetylase inhibitor improved inter-generic cloned leopard cat blastocysts. | 2010 | Theriogenology | pmid:20708232 |
Saini M et al. | Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro. | 2014 | Theriogenology | pmid:25151601 |
Wang YS et al. | Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. | 2011 | Theriogenology | pmid:21144561 |
Shiratsuki S et al. | Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. | 2011 | Theriogenology | pmid:21144563 |
Luo C et al. | Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos. | 2013 | Theriogenology | pmid:24007823 |
Sugimura S et al. | Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. | 2009 | Theriogenology | pmid:19524287 |
Shao GB et al. | Effect of trychostatin A treatment on gene expression in cloned mouse embryos. | 2009 | Theriogenology | pmid:19246084 |
Li J et al. | High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos. | 2008 | Theriogenology | pmid:18573521 |
Opiela J et al. | In vitro development and cytological quality of inter-species (porcine→bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of adult mesenchymal stem cells. | 2017 | Theriogenology | pmid:28583605 |
Ding X et al. | Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A. | 2008 | Theriogenology | pmid:18556056 |
Ji Q et al. | Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. | 2013 | Theriogenology | pmid:23347745 |
Toki S et al. | The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. | 2016 | Thorax | pmid:27071418 |
Gao S et al. | CpG methylation of the PAI-1 gene 5'-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines. | 2005 | Thromb. Haemost. | pmid:16268485 |
Dom G et al. | 5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro. | 2013 | Thyroid | pmid:23167291 |
Greenberg VL et al. | Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells. | 2001 | Thyroid | pmid:11349829 |
Jin H et al. | HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. | 2013 | Tissue Eng Part A | pmid:23013422 |
de Boer J et al. | Inhibition of histone acetylation as a tool in bone tissue engineering. | 2006 | Tissue Eng. | pmid:17518660 |
Bolleyn J et al. | Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. | 2011 | Toxicol In Vitro | pmid:21513791 |
Kang J et al. | Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells. | 2005 | Toxicol In Vitro | pmid:15649630 |
Sancak D and Ozden S | Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. | 2015 | Toxicol In Vitro | pmid:26208285 |
Chen J et al. | Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. | 2013 | Toxicol Ind Health | pmid:22294440 |
Luo SF et al. | Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19281832 |
Henkens T et al. | Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17125810 |
Ding SZ et al. | Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23518002 |
Weng YI et al. | Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20678512 |
Zhang Z et al. | Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29054681 |
Cheng X et al. | Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24747804 |