| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenomyosis | D062788 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Carcinoma, Pancreatic Ductal | D021441 | 6 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Bone Marrow Neoplasms | D019046 | 2 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Neuroendocrine Tumors | D018358 | 4 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Cicatrix, Hypertrophic | D017439 | 4 associated lipids |
| Polycystic Kidney, Autosomal Dominant | D016891 | 6 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Leukemia, Myelomonocytic, Acute | D015479 | 6 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim Y et al. | Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. | 2003 | Oncogene | pmid:12584561 |
| Yokota T et al. | Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. | 2004 | Oncogene | pmid:15107822 |
| McGarry LC et al. | Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes. | 2004 | Oncogene | pmid:15107823 |
| Cao K et al. | Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. | 2015 | Oncogene | pmid:25745993 |
| Su SF et al. | miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. | 2013 | Oncogene | pmid:23085757 |
| Deroanne CF et al. | Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. | 2002 | Oncogene | pmid:11821955 |
| Ego T et al. | The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. | 2002 | Oncogene | pmid:12370815 |
| Konduri SD et al. | Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. | 2003 | Oncogene | pmid:12881707 |
| Hajji N et al. | Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. | 2010 | Oncogene | pmid:20118981 |
| Mulholland NM et al. | Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation. | 2003 | Oncogene | pmid:12894222 |
| Wong CH et al. | CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. | 2014 | Oncogene | pmid:23542171 |
| Gurova KV et al. | Expression of prostate specific antigen (PSA) is negatively regulated by p53. | 2002 | Oncogene | pmid:11791186 |
| Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
| Wu Y et al. | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. | 2001 | Oncogene | pmid:11313951 |
| Rashid SF et al. | Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A. | 2001 | Oncogene | pmid:11313934 |
| Krämer OH et al. | Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. | 2008 | Oncogene | pmid:17653085 |
| Lu Z et al. | E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. | 2006 | Oncogene | pmid:16158053 |
| Futamura M et al. | Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells. | 1995 | Oncogene | pmid:7700637 |
| Hajji N et al. | Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. | 2008 | Oncogene | pmid:18071312 |
| Mühlisch J et al. | Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. | 2006 | Oncogene | pmid:16186793 |
| Cismasiu VB et al. | BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. | 2005 | Oncogene | pmid:16091750 |
| Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
| Pulukuri SM et al. | Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer. | 2009 | Oncogene | pmid:19503093 |
| Sirchia SM et al. | Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. | 2000 | Oncogene | pmid:10734315 |
| Toyooka S et al. | Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells. | 2002 | Oncogene | pmid:12082623 |
| Busson M et al. | Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. | 2005 | Oncogene | pmid:15674337 |
| Nishikata I et al. | Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation. | 2011 | Oncogene | pmid:21516122 |
| Jang ER et al. | The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen. | 2004 | Oncogene | pmid:14676837 |
| Campanero MR et al. | The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. | 2008 | Oncogene | pmid:17724474 |
| Zhong S et al. | Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. | 2007 | Oncogene | pmid:17043644 |
| Kostyniuk CL et al. | The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. | 2002 | Oncogene | pmid:12214274 |
| Reid G et al. | Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. | 2005 | Oncogene | pmid:15870696 |
| Shim JS et al. | Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. | 2004 | Oncogene | pmid:14661058 |
| Fleury L et al. | Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. | 2008 | Oncogene | pmid:18317449 |
| Usenko T et al. | Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. | 2003 | Oncogene | pmid:14576829 |
| Kim YJ et al. | HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade. | 2013 | Oncogene | pmid:23435418 |
| Shin HJ et al. | Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. | 2003 | Oncogene | pmid:12813458 |
| Kim TY et al. | Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. | 2003 | Oncogene | pmid:12813468 |
| Suzuki M et al. | Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression. | 2003 | Oncogene | pmid:14647463 |
| Coombes MM et al. | Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. | 2003 | Oncogene | pmid:14654786 |
| Hirose T et al. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | 2003 | Oncogene | pmid:14586402 |
| Vaghefi H and Neet KE | Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. | 2004 | Oncogene | pmid:15361854 |
| Duan H et al. | Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. | 2008 | Oncogene | pmid:18695675 |
| Meng Z et al. | PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. | 2016 | Oncogene | pmid:26279303 |
| Zubia A et al. | Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. | 2009 | Oncogene | pmid:19169274 |
| Lund P et al. | Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. | 2006 | Oncogene | pmid:16568090 |
| Sato N et al. | Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. | 2005 | Oncogene | pmid:15592528 |
| Kondo T et al. | Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. | 2005 | Oncogene | pmid:15637589 |
| Lee SH et al. | Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. | 2009 | Oncogene | pmid:18850007 |
| Baraz L et al. | Tumor suppressor p53 regulates heparanase gene expression. | 2006 | Oncogene | pmid:16474844 |