| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenomyosis | D062788 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Carcinoma, Pancreatic Ductal | D021441 | 6 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Bone Marrow Neoplasms | D019046 | 2 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Neuroendocrine Tumors | D018358 | 4 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Cicatrix, Hypertrophic | D017439 | 4 associated lipids |
| Polycystic Kidney, Autosomal Dominant | D016891 | 6 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Leukemia, Myelomonocytic, Acute | D015479 | 6 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dom G et al. | 5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro. | 2013 | Thyroid | pmid:23167291 |
| Azechi T et al. | Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. | 2013 | J. Atheroscler. Thromb. | pmid:23518467 |
| Gao SM et al. | Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. | 2013 | Exp. Hematol. | pmid:23111066 |
| Liu S et al. | Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. | 2013 | Ann. Surg. Oncol. | pmid:22752337 |
| Viñuelas J et al. | Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts. | 2013 | BMC Biol. | pmid:23442824 |
| Moreaux J et al. | Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors. | 2013 | Br. J. Cancer | pmid:23868005 |
| Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |
| Li M et al. | Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23680675 |
| Algamas-Dimantov A et al. | Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. | 2013 | Cell Oncol (Dordr) | pmid:23307400 |
| Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
| Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
| Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
| Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
| Mehdi O et al. | HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). | 2012 Mar-Apr | Pancreatology | pmid:22487525 |
| Wu TC et al. | Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22626855 |
| Kim YS et al. | Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22634317 |
| Reddy P | Editorial: HDAC inhibition begets more MDSCs. | 2012 | J. Leukoc. Biol. | pmid:22547132 |
| Srirattana K et al. | Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22578161 |
| Truong M et al. | Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence. | 2012 | Br. J. Cancer | pmid:22596233 |
| Hsu DW et al. | Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. | 2012 | Nucleic Acids Res. | pmid:22600736 |
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