trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bianco C et al. | Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23129342 |
| Carbajal A et al. | A novel method for purification of polymerizable tubulin with a high content of the acetylated isotype. | 2013 | Biochem. J. | pmid:23140207 |
| Pelascini LP et al. | Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. | 2013 | Hum. Gene Ther. | pmid:23140481 |
| You BR and Park WH | Trichostatin A induces apoptotic cell death of HeLa cells in a Bcl-2 and oxidative stress-dependent manner. | 2013 | Int. J. Oncol. | pmid:23165748 |
| Ogura A et al. | Recent advancements in cloning by somatic cell nuclear transfer. | 2013 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23166393 |
| Dom G et al. | 5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro. | 2013 | Thyroid | pmid:23167291 |
| Yacqub-Usman K et al. | Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes. | 2013 | Endocrinology | pmid:23539512 |
| Khan DH and Davie JR | HDAC inhibitors prevent the induction of the immediate-early gene FOSL1, but do not alter the nucleosome response. | 2013 | FEBS Lett. | pmid:23542037 |
| Chen J et al. | Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. | 2013 | Toxicol Ind Health | pmid:22294440 |
| Wang F et al. | HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9. | 2013 | Clin Invest Med | pmid:23544610 |
| Poplineau M et al. | Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells. | 2013 | Cell Prolif. | pmid:23510467 |
| Ding SZ et al. | Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23518002 |
| Azechi T et al. | Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. | 2013 | J. Atheroscler. Thromb. | pmid:23518467 |
| Zhao TC et al. | HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. | 2013 | PLoS ONE | pmid:23762381 |
| Saha A et al. | Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity. | 2013 | Bioorg. Med. Chem. | pmid:23719282 |
| Doherty R et al. | Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC). | 2013 | Vet. Immunol. Immunopathol. | pmid:23764468 |
| Liu J et al. | Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. | 2013 | Sci Rep | pmid:23378917 |
| Shah RR et al. | Regulation of primitive hematopoiesis by class I histone deacetylases. | 2013 | Dev. Dyn. | pmid:23184530 |
| Xu M et al. | Histone deacetylase inhibitors induce human renal cell carcinoma cell apoptosis through p-JNK activation. | 2013 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:24144737 |
| Peng L et al. | [Tricostantin A inhibits self-renewal of breast cancer stem cells in vitro]. | 2013 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:24144739 |
| Chen X et al. | The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells. | 2013 | Cell Death Dis | pmid:24157878 |
| Liu YQ et al. | Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. | 2013 | Genet. Mol. Res. | pmid:24089095 |
| Florea AM | DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals. | 2013 | Biomed Res Int | pmid:24093099 |
| Liu S et al. | Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. | 2013 | Ann. Surg. Oncol. | pmid:22752337 |
| Jiao F et al. | Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. | 2013 | Stem Cells Dev. | pmid:23750509 |
| Tian Y et al. | Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. | 2013 | PLoS ONE | pmid:24367661 |
| Jung AR et al. | Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment. | 2013 | Anticancer Res. | pmid:23482750 |
| Piazza R et al. | Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. | 2013 | Neoplasia | pmid:23633923 |
| Hu X et al. | Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner. | 2013 | Stem Cells Dev. | pmid:22873791 |
| Sachweh MC et al. | Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression. | 2013 | Cell Death Dis | pmid:23470540 |
| Hudson RS et al. | Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. | 2013 | Mol. Cancer | pmid:23409773 |
| Camolotto SA et al. | PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. | 2013 | PLoS ONE | pmid:23418492 |
| Zutz C et al. | Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus. | 2013 | Toxins (Basel) | pmid:24105402 |
| Kim TW et al. | Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. | 2013 | BMC Cancer | pmid:24160266 |
| Moreaux J et al. | Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors. | 2013 | Br. J. Cancer | pmid:23868005 |
| Neumann F et al. | EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors. | 2013 | Cancer Immunol. Immunother. | pmid:23619976 |
| Yang H et al. | Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. | 2013 | Biochem. Pharmacol. | pmid:23643933 |
| Majumder A et al. | Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors. | 2013 | Stem Cell Res | pmid:23644509 |
| Arbuckle JH et al. | Mapping the telomere integrated genome of human herpesvirus 6A and 6B. | 2013 | Virology | pmid:23648233 |
| Di Micco S et al. | Structural basis for the design and synthesis of selective HDAC inhibitors. | 2013 | Bioorg. Med. Chem. | pmid:23693069 |
| Xia X et al. | Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. | 2013 | Transplantation | pmid:23694951 |
| Fan J et al. | Inhibition of HDAC2 protects the retina from ischemic injury. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23696608 |
| Li M et al. | Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23680675 |
| Koch M et al. | Overcoming chemotherapy resistance of ovarian cancer cells by liposomal cisplatin: molecular mechanisms unveiled by gene expression profiling. | 2013 | Biochem. Pharmacol. | pmid:23396090 |
| Iwashita J et al. | Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes. | 2013 | Dev. Growth Differ. | pmid:23346879 |
| Ji Q et al. | Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. | 2013 | Theriogenology | pmid:23347745 |
| Theisen JW et al. | Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. | 2013 | J. Biol. Chem. | pmid:23349465 |
| Nunes MJ et al. | Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. | 2013 | PLoS ONE | pmid:23326422 |
| Murko C et al. | Histone deacetylase inhibitor Trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. | 2013 | Differentiation | pmid:23328540 |
| Algamas-Dimantov A et al. | Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. | 2013 | Cell Oncol (Dordr) | pmid:23307400 |