Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Duhamel M et al. | Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. | 2008 | FEBS Lett. | pmid:18206652 |
Campanero MR et al. | The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. | 2008 | Oncogene | pmid:17724474 |
Nishino N et al. | Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides. | 2008 | Bioorg. Med. Chem. | pmid:17900911 |
Narver HL et al. | Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. | 2008 | Ann. Neurol. | pmid:18661558 |
Kovács P and Csaba G | The effect of histone deacetylase inhibitor trichostatin A (TSA) on the incorporation of 32P (Pi) and 3H-palmitic acid into the phospholipids of Tetrahymena. | 2008 Jan-Feb | Cell Biochem. Funct. | pmid:17191269 |
Smetana K et al. | To the nucleolar density and size in apoptotic human leukemic myeloblasts produced in vitro by Trichostatin A. | 2008 Jul-Sep | Eur J Histochem | pmid:18840553 |
Fenic I et al. | In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. | 2008 Mar-Apr | J. Androl. | pmid:18046049 |
Nishikiori N et al. | Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9. | 2008 May-Jun | Jpn. J. Ophthalmol. | pmid:18661270 |
Li X and Bai XZ | [NF-kappaB modulates activation of the BMP-2 gene by trichostatin A]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140318 |
Kir'ianov GI et al. | [Nucleosome positioning within neomycinphosphotransferase gene (NPTII) on yeast plasmid in repressed and active state]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140324 |
Miyoshi M et al. | Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells. | 2008 Nov-Dec | Nutrition | pmid:18723323 |
Susick L et al. | Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. | 2008 Sep-Oct | J. Cell. Mol. Med. | pmid:18053091 |
Wallace DM and Cotter TG | Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina. | 2009 | J. Neurosci. Res. | pmid:18951482 |
Li M et al. | Upregulation of human with-no-lysine kinase-4 gene expression by GATA-1 acetylation. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18793746 |
Patel V et al. | Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. | 2009 | J. Med. Chem. | pmid:19317450 |
GarcÃa-Villegas R et al. | Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na(x) gene (Scn7a). | 2009 | J. Neurosci. Res. | pmid:19326446 |
Seo J et al. | Differential expression of stromal cell-derived factor 1 in human brain microvascular endothelial cells and pericytes involves histone modifications. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19289100 |
Cecconi D et al. | Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. | 2009 | Proteomics | pmid:19294695 |
Ikeda S et al. | Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts. | 2009 | Zygote | pmid:19356267 |
Morita K et al. | Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. | 2009 | J. Neurosci. Res. | pmid:19360904 |
Chiou SK and Hoa N | Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. | 2009 | Apoptosis | pmid:19757064 |
Vire B et al. | Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. | 2009 | PLoS ONE | pmid:19759901 |
Beebe LF et al. | Cytochalasin B and trichostatin a treatment postactivation improves in vitro development of porcine somatic cell nuclear transfer embryos. | 2009 | Cloning Stem Cells | pmid:19780698 |
Olsen CA and Ghadiri MR | Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides. | 2009 | J. Med. Chem. | pmid:19705846 |
Kee HJ and Kook H | Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy. | 2009 | J. Mol. Cell. Cardiol. | pmid:19729022 |
Ong DC et al. | LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer. | 2009 | Oncogene | pmid:19734946 |
Alao JP et al. | Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay. | 2009 | Mol. Cancer Ther. | pmid:19723888 |
Bennett KL et al. | AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. | 2009 | PLoS ONE | pmid:19742317 |
Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. | 2009 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:19742343 |
Hostetter CL et al. | Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. | 2009 | Cancer Lett. | pmid:19013015 |
Heo H et al. | Suppression of caspase-11 expression by histone deacetylase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013432 |
Chen FQ et al. | Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea. | 2009 | J. Neurochem. | pmid:19141081 |
Kekatpure VD et al. | HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. | 2009 | J. Biol. Chem. | pmid:19158084 |
Sutcliffe EL et al. | Dynamic histone variant exchange accompanies gene induction in T cells. | 2009 | Mol. Cell. Biol. | pmid:19158270 |
Bagui TK et al. | Inhibition of p27Kip1 gene transcription by mitogens. | 2009 | Cell Cycle | pmid:19158484 |
Wang X et al. | Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes. | 2009 | Growth Factors | pmid:19107653 |
Cao Y et al. | Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19966229 |
Trunzer M et al. | Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation. | 2009 | J. Med. Chem. | pmid:19108654 |
Smil DV et al. | Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19111466 |
Azzi A et al. | Schistosoma mansoni: developmental arrest of miracidia treated with histone deacetylase inhibitors. | 2009 | Exp. Parasitol. | pmid:19094990 |
Hambach L et al. | Hypomethylating drugs convert HA-1-negative solid tumors into targets for stem cell-based immunotherapy. | 2009 | Blood | pmid:19096014 |
Mavis CK et al. | Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. | 2009 | Prostate | pmid:19444856 |
Samuni Y et al. | The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation. | 2009 | Free Radic. Biol. Med. | pmid:19447172 |
Gavin DP et al. | Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. | 2009 | J Psychiatry Neurosci | pmid:19448855 |
Kim HN et al. | Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. | 2009 | Eur. J. Pharmacol. | pmid:19766111 |
Araki H et al. | Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues. | 2009 | Exp. Hematol. | pmid:19501128 |
Pulukuri SM et al. | Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer. | 2009 | Oncogene | pmid:19503093 |
Tian F et al. | Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1. | 2009 | J. Neurochem. | pmid:19476549 |
Han SB and Lee JK | Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages. | 2009 | Arch. Pharm. Res. | pmid:19407980 |
Lee JH et al. | Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. | 2009 | J. Mol. Biol. | pmid:19573535 |
Gan YH and Zhang S | PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells. | 2009 | Oral Oncol. | pmid:19574087 |
Wang XX and Fu L | [Recent advances in DNA demethylation in tumor therapy]. | 2009 | Zhonghua Bing Li Xue Za Zhi | pmid:19575888 |
Soriano FX et al. | Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2. | 2009 | Epigenetics | pmid:19430206 |
Sawarkar R et al. | Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum. | 2009 | J. Mol. Biol. | pmid:19576222 |
Hsu PY et al. | Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells. | 2009 | Cancer Res. | pmid:19549897 |
Noh H et al. | Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19553350 |
Jonsen MD et al. | The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. | 2009 | Mol. Endocrinol. | pmid:19556346 |
Link PA et al. | Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells. | 2009 | Mol. Cancer Res. | pmid:19531572 |
Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
Casero RA and Woster PM | Recent advances in the development of polyamine analogues as antitumor agents. | 2009 | J. Med. Chem. | pmid:19534534 |
Dubois F et al. | Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. | 2009 | Mol. Biochem. Parasitol. | pmid:19538992 |
Pang M et al. | Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19640900 |
Monks A et al. | Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. | 2009 | Anticancer Drugs | pmid:19606018 |
Hemmatazad H et al. | Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis. | 2009 | Arthritis Rheum. | pmid:19404935 |
Gaymes TJ et al. | Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. | 2009 | Haematologica | pmid:19407318 |
Kim SN et al. | Regulation of adipocyte differentiation by histone deacetylase inhibitors. | 2009 | Arch. Pharm. Res. | pmid:19407971 |
Hirose N et al. | ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19422799 |
Park SJ et al. | Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. | 2009 | Biochem. Pharmacol. | pmid:19426671 |
Piotrowska H and Jagodzinski PP | Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. | 2009 | Arch. Med. Res. | pmid:19427965 |
López-Soto A et al. | HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer. | 2009 | Oncogene | pmid:19430493 |
Kim W et al. | Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis. | 2009 | Cell Res. | pmid:19436261 |
Yoshida M | Chemical genomics: a key to the epigenome - an interview with Minoru Yoshida. Interview by Saadi Khochbin. | 2009 | Int. J. Dev. Biol. | pmid:19412886 |
Han DW et al. | Epigenetic hierarchy governing Nestin expression. | 2009 | Stem Cells | pmid:19415779 |
Derks S et al. | Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. | 2009 | Carcinogenesis | pmid:19329758 |
Liu X et al. | The improvement of adenovirus vector production by increased expression of coxsackie adenovirus receptor. | 2009 | Biotechnol. Lett. | pmid:19330491 |
Hollosi P et al. | Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. | 2009 | Int. J. Cancer | pmid:19330836 |
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Kusakabe M et al. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19878646 |
Ma X et al. | Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach. | 2009 | Mol. Cancer Ther. | pmid:19887557 |
Puca R et al. | HIPK2 modulates p53 activity towards pro-apoptotic transcription. | 2009 | Mol. Cancer | pmid:19828042 |
Röhrs S et al. | Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia. | 2009 | Mol. Cancer | pmid:19835597 |
Kawamura T et al. | Inhibitory effects of short-chain fatty acids on matrix metalloproteinase secretion from human colonic subepithelial myofibroblasts. | 2009 | Dig. Dis. Sci. | pmid:18629644 |
von Dassow G et al. | Action at a distance during cytokinesis. | 2009 | J. Cell Biol. | pmid:20008563 |
Kakihana M et al. | Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition. | 2009 | J Thorac Oncol | pmid:20009910 |
Peng DF et al. | DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. | 2009 | Gut | pmid:18664505 |
O'Leary DA et al. | Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. | 2009 | PLoS ONE | pmid:20020055 |
Halaban R et al. | Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. | 2009 | PLoS ONE | pmid:19234609 |
Maalouf WE et al. | Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term. | 2009 | BMC Dev. Biol. | pmid:19210795 |
Sakurai T et al. | Induction of endogenous interferon tau gene transcription by CDX2 and high acetylation in bovine nontrophoblast cells. | 2009 | Biol. Reprod. | pmid:19211809 |
Chakravorty M et al. | IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. | 2009 | Int. J. Biochem. Cell Biol. | pmid:19166966 |
Zhang D et al. | [Synergistic cytotoxicity effect of histone deacetylase inhibitor combined with paclitaxel on lung cancer cell lines and its mechanism]. | 2009 | Ai Zheng | pmid:19958621 |
Lu MC et al. | Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. | 2009 | Arch. Toxicol. | pmid:18709356 |
Sharma A et al. | Trichostatin a inhibits corneal haze in vitro and in vivo. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19168895 |
Li X et al. | Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. | 2009 | Blood | pmid:19864643 |
Zubia A et al. | Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. | 2009 | Oncogene | pmid:19169274 |
Gray SG et al. | Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. | 2009 | Eur. J. Cancer | pmid:19818596 |
Hara D et al. | Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19818730 |
Hoebeeck J et al. | Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. | 2009 | Cancer Lett. | pmid:18819746 |
Lee SH et al. | Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. | 2009 | Oncogene | pmid:18850007 |
Katsura T et al. | The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells. | 2009 | Cancer Gene Ther. | pmid:18949013 |