Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Chen J and Kang JH | Quercetin and trichostatin A cooperatively kill human leukemia cells. | 2005 | Pharmazie | pmid:16320950 |
Wei M et al. | BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. | 2005 | Cancer Res. | pmid:16322213 |
Marchion DC et al. | Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. | 2005 | Clin. Cancer Res. | pmid:16322310 |
Hammond SM et al. | Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia. | 2005 | Leuk. Res. | pmid:15541480 |
Chang S and Pikaard CS | Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. | 2005 | J. Biol. Chem. | pmid:15516340 |
Yanada M et al. | Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. | 2005 | Oncol. Rep. | pmid:16142337 |
Uchida H et al. | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2005 | Endocrinology | pmid:16123169 |
Su M et al. | Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells. | 2005 | J. Biol. Chem. | pmid:16087680 |
Somech R et al. | The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. | 2005 | J. Cell. Sci. | pmid:16129885 |
Cho HH et al. | Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. | 2005 | J. Cell. Biochem. | pmid:16088945 |
Gurvich N et al. | Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. | 2005 | FASEB J. | pmid:15901671 |
Peltonen K et al. | Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis. | 2005 | Pigment Cell Res. | pmid:15892716 |
Schwahn DJ et al. | Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. | 2005 | Pigment Cell Res. | pmid:15892717 |
Ranganathan P and Rangnekar VM | Exploiting the TSA connections to overcome apoptosis-resistance. | 2005 | Cancer Biol. Ther. | pmid:15908800 |
Rincón-Arano H et al. | YY1 and GATA-1 interaction modulate the chicken 3'-side alpha-globin enhancer activity. | 2005 | J. Mol. Biol. | pmid:15913647 |
Shetty S et al. | Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. | 2005 | Mol. Cell. Biol. | pmid:15964798 |
Place RF et al. | HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. | 2005 | Biochem. Pharmacol. | pmid:15950952 |
Wooten LG and Ogretmen B | Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. | 2005 | J. Biol. Chem. | pmid:15951564 |
Xu S et al. | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. | 2005 | J. Hum. Genet. | pmid:15824892 |
Strait KA et al. | Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. | 2005 | Mol. Cancer Ther. | pmid:15827334 |
Magner WJ and Tomasi TB | Apoptotic and necrotic cells induced by different agents vary in their expression of MHC and costimulatory genes. | 2005 | Mol. Immunol. | pmid:15829293 |
Hu J and Colburn NH | Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. | 2005 | Mol. Cancer Res. | pmid:15755876 |
Senawong T et al. | BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. | 2005 | Arch. Biochem. Biophys. | pmid:15639232 |
Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |
Kawano T et al. | Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect. | 2004 Sep-Oct | Anticancer Res. | pmid:15517875 |
Fenic I et al. | In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. | 2004 Sep-Oct | J. Androl. | pmid:15292114 |
Emionite L et al. | Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines. | 2004 Nov-Dec | Anticancer Res. | pmid:15736447 |
Karasawa Y and Okisaka S | Inhibition of histone deacetylation by butyrate induces morphological changes in Y79 retinoblastoma cells. | 2004 Nov-Dec | Jpn. J. Ophthalmol. | pmid:15592778 |
Flørenes VA et al. | Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. | 2004 | Melanoma Res. | pmid:15179185 |
Ahn MR et al. | Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. | 2004 | Arch. Pharm. Res. | pmid:15180307 |
Vanhaecke T et al. | Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. | 2004 | Curr. Med. Chem. | pmid:15180568 |
Kato N et al. | Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. | 2004 | Cell Death Differ. | pmid:15153943 |
Ramakrishnan G et al. | Histone acetyltransferases and deacetylase in Entamoeba histolytica. | 2004 | Mol. Biochem. Parasitol. | pmid:15555732 |
Zoumpoulidou G et al. | Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). | 2004 | Mol. Endocrinol. | pmid:15155784 |
Wang LG et al. | Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. | 2004 | Oncogene | pmid:15156193 |
Romanski A et al. | Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. | 2004 | Haematologica | pmid:15075075 |
Bayart E et al. | A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. | 2004 | Cancer Res. | pmid:15604258 |
Ishii S et al. | Aberrant dynamics of histone deacetylation at the thyrotropin-releasing hormone gene in resistance to thyroid hormone. | 2004 | Mol. Endocrinol. | pmid:15131262 |
Winn RA and Heasley LE | Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. | 2004 | Chest | pmid:15136458 |
Jin YH et al. | Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. | 2004 | J. Biol. Chem. | pmid:15138260 |
Milutinovic S et al. | DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation. | 2004 | J. Biol. Chem. | pmid:15087453 |
Chang HC et al. | Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. | 2004 | Cell. Signal. | pmid:15093608 |
Nishino N et al. | Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109626 |
Marson CM et al. | Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109636 |
Arapshian A et al. | Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. | 2004 | Mol. Cancer | pmid:15113415 |
Mizukami T et al. | Effects of trichostatin a, a histone deacetylase inhibitor, on mouse gonadal development in vitro. | 2004 | J. Reprod. Dev. | pmid:15118250 |
Ganslmayer M et al. | A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. | 2004 | Oncol. Rep. | pmid:15069530 |
Margueron R et al. | Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. | 2004 | J. Mol. Endocrinol. | pmid:15072561 |
Reifenberger J et al. | Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. | 2004 | Int. J. Cancer | pmid:14961576 |
Sugimoto S et al. | Expression and regulation of tumor suppressor gene maspin in human bladder cancer. | 2004 | Cancer Lett. | pmid:14732229 |
Lu XC et al. | [Effect of inhibitors for demethylation and histone deacetylase on proliferation of cell line K562 and expression of tumor related genes]. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:14989767 |
Nojima H et al. | Increase in DNA methylation downregulates conceptus interferon-tau gene expression. | 2004 | Mol. Reprod. Dev. | pmid:14991730 |
Chua YL et al. | Microarray analysis of chromatin-immunoprecipitated DNA identifies specific regions of tobacco genes associated with acetylated histones. | 2004 | Plant J. | pmid:14996214 |
Khan AN et al. | An epigenetically altered tumor cell vaccine. | 2004 | Cancer Immunol. Immunother. | pmid:14997346 |
Ragno R et al. | 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. | 2004 | J. Med. Chem. | pmid:14998325 |
Koch A et al. | Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12871851 |
Zelko IN and Folz RJ | Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. | 2004 | Free Radic. Biol. Med. | pmid:15451065 |
Chiba T et al. | Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. | 2004 | Oncology | pmid:15452378 |
Jose B et al. | Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15454224 |
Uramoto H et al. | p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. | 2004 | J. Cell. Sci. | pmid:15454570 |
Wang S and Zhu J | The hTERT gene is embedded in a nuclease-resistant chromatin domain. | 2004 | J. Biol. Chem. | pmid:15516693 |
El-Khoury V et al. | Effects of the histone deacetylase inhibitor trichostatin A on nuclear texture and c-jun gene expression in drug-sensitive and drug-resistant human H69 lung carcinoma cells. | 2004 | Cytometry A | pmid:15517561 |
Vaquero A et al. | Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. | 2004 | Mol. Cell | pmid:15469825 |
Ladd PD et al. | Identification of a genomic fragment that directs hematopoietic-specific expression of Rac2 and analysis of the DNA methylation profile of the gene locus. | 2004 | Gene | pmid:15474314 |
Li H and Wu X | Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474507 |
Spenger A et al. | Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. | 2004 | Protein Expr. Purif. | pmid:15477077 |
Yee SB et al. | Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. | 2004 | Int. J. Oncol. | pmid:15492835 |
Young JC et al. | Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. | 2004 | Cytotherapy | pmid:16146885 |
Um SJ et al. | In vitro antitumor potential of 4-BPRE, a butyryl aminophenyl ester of retinoic acid: role of the butyryl group. | 2004 | Oncol. Rep. | pmid:14767528 |
Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
Fan X et al. | Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. | 2004 | J. Cell. Biochem. | pmid:15389882 |
Astrand C et al. | Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure. | 2004 | Eur. J. Biochem. | pmid:15009194 |
Chen YX et al. | Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. | 2004 | World J. Gastroenterol. | pmid:15309711 |
Heltweg B et al. | Subtype selective substrates for histone deacetylases. | 2004 | J. Med. Chem. | pmid:15456267 |
Alikhani-Koopaei R et al. | Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. | 2004 | J. Clin. Invest. | pmid:15489962 |
Marsili G et al. | Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659847 |
Jang ER et al. | The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen. | 2004 | Oncogene | pmid:14676837 |
Thelen P et al. | Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. | 2004 | Int. J. Oncol. | pmid:14654937 |
Kramps C et al. | E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. | 2004 | J. Biol. Chem. | pmid:14645238 |
Chaturvedi V et al. | Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53. | 2004 | J. Cell. Physiol. | pmid:14584049 |
Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
Facchetti F et al. | Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. | 2004 | Apoptosis | pmid:15314285 |
Roh MS et al. | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | 2004 | Apoptosis | pmid:15314286 |
Yanaihara N et al. | Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. | 2004 | Int. J. Cancer | pmid:15305387 |
Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
Schultz BE et al. | Kinetics and comparative reactivity of human class I and class IIb histone deacetylases. | 2004 | Biochemistry | pmid:15323567 |
Tao D et al. | Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. | 2004 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:15346199 |
Korkmaz CG et al. | Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants. | 2004 | J. Endocrinol. | pmid:15350180 |
Akimoto T | [Potentiation of radiation-induced cell killing by histone deacetylase inhibitor]. | 2004 | Nippon Rinsho | pmid:15283155 |
Joung KE et al. | Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15283467 |
Kang J et al. | Synergistic killing of human leukemia cells by antioxidants and trichostatin A. | 2004 | Cancer Chemother. Pharmacol. | pmid:15248029 |
Jin B and Ryu DY | Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes. | 2004 | J. Biochem. Mol. Toxicol. | pmid:15252868 |
Gilchrist S et al. | Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. | 2004 | Chromosome Res. | pmid:15254368 |
Li X et al. | Regulation of histone acetylation and apoptosis by trichostatin in HL-60 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15791844 |
Lu H et al. | Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. | 2004 | J. Virol. | pmid:15194748 |
Moldenhauer A et al. | Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins. | 2004 | J. Leukoc. Biol. | pmid:15197237 |
Min KN et al. | Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15202563 |
Jia S et al. | RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. | 2004 | Science | pmid:15218150 |
Sumer H et al. | Effects of scaffold/matrix alteration on centromeric function and gene expression. | 2004 | J. Biol. Chem. | pmid:15220334 |
Lee YJ et al. | Mechanism of transcriptional repression by TEL/RUNX1 fusion protein. | 2004 | Mol. Cells | pmid:15179033 |