Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Henderson C et al. | Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). | 2003 | J. Biol. Chem. | pmid:12556448 |
Palazzo A et al. | Cell biology: Tubulin acetylation and cell motility. | 2003 | Nature | pmid:12529632 |
Lietz M et al. | RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. | 2003 | Eur. J. Biochem. | pmid:12492469 |
Yamashita Y et al. | Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. | 2003 | Int. J. Cancer | pmid:12494463 |
Rahman MM et al. | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. | 2003 | Blood | pmid:12511413 |
Musikacharoen T et al. | Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. | 2003 | J. Biol. Chem. | pmid:12511574 |
Gusterson RJ et al. | The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. | 2003 | J. Biol. Chem. | pmid:12477714 |
James SY et al. | Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. | 2003 | Cancer Res. | pmid:12839938 |
Parekh-Olmedo H et al. | The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. | 2003 | Ann. N. Y. Acad. Sci. | pmid:14751821 |
Nambu Y et al. | Transcription-coupled events associating with immunoglobulin switch region chromatin. | 2003 | Science | pmid:14684824 |
Haggarty SJ et al. | Small molecule modulation of the human chromatid decatenation checkpoint. | 2003 | Chem. Biol. | pmid:14700634 |
Kim DK et al. | Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14667227 |
Huang H et al. | Expression of P53, P21 in human lung adenocarcinoma A549 cell strains under hypoxia conditions and the effect of TSA on their expression. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15015635 |
Mulholland NM et al. | Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation. | 2003 | Oncogene | pmid:12894222 |
Banwell CM et al. | Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation. | 2003 | Recent Results Cancer Res. | pmid:12899515 |
Yan Y et al. | Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12902198 |
Augenlicht L et al. | Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation. | 2003 | Oncogene | pmid:12902981 |
Cho B et al. | Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12849980 |
Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
Hong CY et al. | Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B. | 2003 | Mol. Cell. Biol. | pmid:12917325 |
Le Masson I et al. | Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. | 2003 | Mol. Cell. Biol. | pmid:12917332 |
Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
Condon JC et al. | A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12886011 |
Thomas RM et al. | Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen. | 2003 | J. Immunol. | pmid:12496403 |
Xu Y et al. | SHP-1 sensitizes MCF-7 cells to trichostatin A-induced apoptosis by modulating PI3K-dependent events. | 2003 | Cell Death Differ. | pmid:14502244 |
Donadelli M et al. | Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells. | 2003 | Mol. Carcinog. | pmid:14502645 |
Tominaga K et al. | MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. | 2003 | J. Biol. Chem. | pmid:14506250 |
Kawai H et al. | Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. | 2003 | Int. J. Cancer | pmid:14506733 |
Witt O et al. | Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. | 2003 | Blood | pmid:12393499 |
Yang L et al. | An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. | 2003 | Biochem. J. | pmid:12398767 |
Méndez-Pertuz M et al. | The thyroid hormone receptor antagonizes CREB-mediated transcription. | 2003 | EMBO J. | pmid:12805224 |
Illi B et al. | Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression. | 2003 | Circ. Res. | pmid:12805238 |
Bhakat KK and Mitra S | CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. | 2003 | Carcinogenesis | pmid:12807730 |
Lopatina NG et al. | Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12810068 |
Liu LT et al. | Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. | 2003 | Cancer Res. | pmid:12810630 |
Shin HJ et al. | Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. | 2003 | Oncogene | pmid:12813458 |
Kim TY et al. | Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. | 2003 | Oncogene | pmid:12813468 |
Kim JM et al. | Changes in histone acetylation during mouse oocyte meiosis. | 2003 | J. Cell Biol. | pmid:12835313 |
Coombes MM et al. | Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. | 2003 | Oncogene | pmid:14654786 |
Chan AS et al. | Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. | 2003 | Oncogene | pmid:14534543 |
Allison SJ and Milner J | Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. | 2003 | Cancer Res. | pmid:14583461 |
Mai A et al. | Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. | 2003 | J. Med. Chem. | pmid:14584932 |
Pace BS et al. | p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. | 2003 | Exp. Hematol. | pmid:14585374 |
Shteper PJ et al. | Role of promoter methylation in regulation of the mammalian heparanase gene. | 2003 | Oncogene | pmid:14586400 |
Hirose T et al. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | 2003 | Oncogene | pmid:14586402 |
Huang H et al. | [HDAC1 expression and effect of TSA on proliferation and apoptosis of A549 cells]. | 2003 | Ai Zheng | pmid:12969522 |
Ohike N et al. | Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas. | 2003 | Cancer Lett. | pmid:12969792 |
Fass DM et al. | Deacetylase activity is required for cAMP activation of a subset of CREB target genes. | 2003 | J. Biol. Chem. | pmid:12939274 |
Zhao C et al. | A composite motif of the Drosophila morphogenetic protein bicoid critical to transcription control. | 2003 | J. Biol. Chem. | pmid:12939280 |
Hinoi T et al. | Silencing of CDX2 expression in colon cancer via a dominant repression pathway. | 2003 | J. Biol. Chem. | pmid:12947088 |
Nakano M et al. | Epigenetic assembly of centromeric chromatin at ectopic alpha-satellite sites on human chromosomes. | 2003 | J. Cell. Sci. | pmid:12953060 |
Kim EJ et al. | Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. | 2003 | Nucleic Acids Res. | pmid:12954772 |
Brugarolas JB et al. | TSC2 regulates VEGF through mTOR-dependent and -independent pathways. | 2003 | Cancer Cell | pmid:12957289 |
Cimini D et al. | Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. | 2003 | Mol. Biol. Cell | pmid:12972566 |
Schuettengruber B et al. | Autoregulation of mouse histone deacetylase 1 expression. | 2003 | Mol. Cell. Biol. | pmid:12972616 |
Yang Y et al. | The histone code regulating expression of the imprinted mouse Igf2r gene. | 2003 | Endocrinology | pmid:12975326 |
Hu E et al. | Identification of novel isoform-selective inhibitors within class I histone deacetylases. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12975486 |
Hoever G et al. | The mechanism of 3'-azido-2',3'-dideoxythymidine resistance to human lymphoid cells. | 2003 | Int. J. Mol. Med. | pmid:12736716 |
Valenta T et al. | HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. | 2003 | Nucleic Acids Res. | pmid:12711682 |
Arora T et al. | PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. | 2003 | J. Biol. Chem. | pmid:12716907 |
Sonoyama K et al. | Upregulation of activin A gene by butyrate in human colon cancer cell lines. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12540370 |
Kagoshima M et al. | Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. | 2003 | Biochem. Soc. Trans. | pmid:12546654 |
Bhat RA et al. | Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. | 2003 | Plant J. | pmid:12581304 |
Jang IC et al. | Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. | 2003 | Plant J. | pmid:12581311 |
Bouchain G et al. | Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:12593661 |
Castro-Galache MD et al. | Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. | 2003 | Int. J. Cancer | pmid:12594812 |
Teyssier C et al. | Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. | 2003 | Mol. Endocrinol. | pmid:12554755 |
Noss KR et al. | Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. | 2002 May-Jun | Anticancer Res. | pmid:12168830 |
Rahman I et al. | Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. | 2002 May-Jun | Mol. Cell. Biochem. | pmid:12162440 |
Iwata K et al. | Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470611 |
Sourlingas TG et al. | The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. | 2002 Jan-Mar | Exp. Gerontol. | pmid:11772521 |
López-Solache I et al. | Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. | 2002 | Endocrine | pmid:12588052 |
Blagosklonny MV et al. | Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. | 2002 | Mol. Cancer Ther. | pmid:12481415 |
Kim JY et al. | Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation. | 2002 | Anal. Chem. | pmid:12433071 |
Elaut G et al. | Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:12433798 |
Yáñez RJ and Porter AC | A chromosomal position effect on gene targeting in human cells. | 2002 | Nucleic Acids Res. | pmid:12433992 |
Takechi S et al. | Chicken HDAC2 down-regulates IgM light chain gene promoter activity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437980 |
Ego T et al. | The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. | 2002 | Oncogene | pmid:12370815 |
McBurney MW et al. | Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes. | 2002 | Exp. Cell Res. | pmid:11855851 |
Hou M et al. | The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells. | 2002 | Exp. Cell Res. | pmid:11855854 |
Remiszewski SW et al. | Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. | 2002 | J. Med. Chem. | pmid:11831887 |
Kiefer SM et al. | Murine Sall1 represses transcription by recruiting a histone deacetylase complex. | 2002 | J. Biol. Chem. | pmid:11836251 |
Roddie PH et al. | Primary acute myeloid leukaemia blasts resistant to cytokine-induced differentiation to dendritic-like leukaemia cells can be forced to differentiate by the addition of bryostatin-1. | 2002 | Leukemia | pmid:11840267 |
Taniura S et al. | Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells. | 2002 | J. Biol. Chem. | pmid:11877441 |
Heltweg B and Jung M | A microplate reader-based nonisotopic histone deacetylase activity assay. | 2002 | Anal. Biochem. | pmid:11878795 |
Wittich S et al. | Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. | 2002 | J. Med. Chem. | pmid:12109913 |
Toyooka S et al. | Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures. | 2002 | Clin. Cancer Res. | pmid:12114433 |
Choi HS et al. | Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12200149 |
Maecker HL et al. | Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. | 2002 | Cancer Cell | pmid:12204534 |
Fang D et al. | Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. | 2002 | Nucleic Acids Res. | pmid:12136092 |
Zschocke J et al. | Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells. | 2002 | J. Biol. Chem. | pmid:12138116 |
Yu Z et al. | Histone deacetylases augment cytokine induction of the iNOS gene. | 2002 | J. Am. Soc. Nephrol. | pmid:12138131 |
Li J et al. | Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. | 2002 | Mol. Cell. Biol. | pmid:12138181 |
Iezzi S et al. | Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032356 |
Nielsen J | Combinatorial synthesis of natural products. | 2002 | Curr Opin Chem Biol | pmid:12023109 |
Mikkelsen IM et al. | The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress. | 2002 | Mol. Cell. Biochem. | pmid:12030384 |
Bharadwaj S and Prasad GL | Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. | 2002 | Cancer Lett. | pmid:12065096 |
Ito K et al. | A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12070353 |
Katula KS et al. | Cell cycle specific changes in the human cyclin B1 gene regulatory region as revealed by response to trichostatin A. | 2002 | Arch. Biochem. Biophys. | pmid:12054478 |
Wang XQ et al. | Histone deacetylase inhibition results in decreased macrophage CD9 expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12056820 |