Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Maatouk DM and Resnick JL | Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation. | 2003 | Dev. Biol. | pmid:12781693 |
Kang J et al. | Nickel-induced histone hypoacetylation: the role of reactive oxygen species. | 2003 | Toxicol. Sci. | pmid:12773760 |
Agoulnik IU et al. | Repressors of androgen and progesterone receptor action. | 2003 | J. Biol. Chem. | pmid:12771131 |
Koeller KM et al. | Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. | 2003 | Chem. Biol. | pmid:12770822 |
Bartoli A et al. | Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells. | 2003 | Pharmacol. Res. | pmid:12770523 |
Génin P et al. | Impairment of interferon-induced IRF-7 gene expression due to inhibition of ISGF3 formation by trichostatin A. | 2003 | J. Virol. | pmid:12768031 |
Klisovic DD et al. | Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12766035 |
Zhao S et al. | Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. | 2003 | Cancer Res. | pmid:12750289 |
Van Ommeslaeghe K et al. | Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12749885 |
Enright BP et al. | Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. | 2003 | Biol. Reprod. | pmid:12748129 |
Craig JM et al. | Centromeric chromatin pliability and memory at a human neocentromere. | 2003 | EMBO J. | pmid:12743043 |
Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |
Hoever G et al. | The mechanism of 3'-azido-2',3'-dideoxythymidine resistance to human lymphoid cells. | 2003 | Int. J. Mol. Med. | pmid:12736716 |
Chambers AE et al. | Histone acetylation-mediated regulation of genes in leukaemic cells. | 2003 | Eur. J. Cancer | pmid:12736119 |
Farhan H et al. | Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. | 2003 | J. Steroid Biochem. Mol. Biol. | pmid:12732287 |
Jedrusik MA and Schulze E | Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. | 2003 | Mol. Cell. Biol. | pmid:12724425 |
Yasui W et al. | Histone acetylation and gastrointestinal carcinogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12724227 |
Arora T et al. | PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. | 2003 | J. Biol. Chem. | pmid:12716907 |
Valenta T et al. | HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. | 2003 | Nucleic Acids Res. | pmid:12711682 |
Mihaylova VT et al. | Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. | 2003 | Mol. Cell. Biol. | pmid:12697826 |
Zika E et al. | Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. | 2003 | Mol. Cell. Biol. | pmid:12697811 |
Lee SC et al. | Activation of terminal B cell differentiation by inhibition of histone deacetylation. | 2003 | Mol. Immunol. | pmid:12695118 |
Rambhatla L et al. | Generation of hepatocyte-like cells from human embryonic stem cells. | 2003 | Cell Transplant | pmid:12693659 |
Schauber J et al. | Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. | 2003 | Gut | pmid:12692061 |
Park WH et al. | Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. | 2003 | Int. J. Oncol. | pmid:12684681 |
Foubister V | Anticancer drug shows promise against lupus. | 2003 | Drug Discov. Today | pmid:12681930 |
Detich N et al. | The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. | 2003 | J. Biol. Chem. | pmid:12676953 |
Vos MD et al. | The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. | 2003 | J. Biol. Chem. | pmid:12676952 |
Kao GD et al. | Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. | 2003 | J. Cell Biol. | pmid:12668657 |
Chandler SP et al. | Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. | 2003 | BMC Mol. Biol. | pmid:12659659 |
Murumägi A et al. | Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. | 2003 | J. Biol. Chem. | pmid:12651856 |
Shi W et al. | Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. | 2003 | Biol. Reprod. | pmid:12646489 |
Huang Y et al. | Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. | 2003 | Int. J. Cancer | pmid:12640681 |
Camarero N et al. | Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. | 2003 | Nucleic Acids Res. | pmid:12626711 |
Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. | 2002 | Brain Tumor Pathol | pmid:12622137 |
Shaker S et al. | Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. | 2003 | Leuk. Res. | pmid:12620295 |
Wang S and Zhu J | Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. | 2003 | J. Biol. Chem. | pmid:12611896 |
Kim SY et al. | Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. | 2003 | J. Virol. | pmid:12610114 |
Sakai N et al. | Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. | 2003 | J. Biol. Chem. | pmid:12609987 |
Ailenberg M and Silverman M | Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604329 |
Castro-Galache MD et al. | Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. | 2003 | Int. J. Cancer | pmid:12594812 |
Bouchain G et al. | Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:12593661 |
Glaser KB et al. | Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. | 2003 | Mol. Cancer Ther. | pmid:12589032 |
Mishra N et al. | Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. | 2003 | J. Clin. Invest. | pmid:12588892 |
López-Solache I et al. | Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. | 2002 | Endocrine | pmid:12588052 |
Kim Y et al. | Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. | 2003 | Oncogene | pmid:12584561 |
Jang IC et al. | Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. | 2003 | Plant J. | pmid:12581311 |
Bhat RA et al. | Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. | 2003 | Plant J. | pmid:12581304 |
Kao HH et al. | Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. | 2003 Jan-Feb | J. Biomed. Sci. | pmid:12566991 |
Tomita K et al. | The effect of oxidative stress on histone acetylation and IL-8 release. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565901 |
Boutillier AL et al. | Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. | 2003 | J. Neurochem. | pmid:12562525 |
Cheutin T et al. | Maintenance of stable heterochromatin domains by dynamic HP1 binding. | 2003 | Science | pmid:12560555 |
Henderson C et al. | Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). | 2003 | J. Biol. Chem. | pmid:12556448 |
Teyssier C et al. | Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. | 2003 | Mol. Endocrinol. | pmid:12554755 |
Kagoshima M et al. | Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. | 2003 | Biochem. Soc. Trans. | pmid:12546654 |
Sonoyama K et al. | Upregulation of activin A gene by butyrate in human colon cancer cell lines. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12540370 |
Fernandes I et al. | Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. | 2003 | Mol. Cell | pmid:12535528 |
Palazzo A et al. | Cell biology: Tubulin acetylation and cell motility. | 2003 | Nature | pmid:12529632 |
Musikacharoen T et al. | Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. | 2003 | J. Biol. Chem. | pmid:12511574 |
Rahman MM et al. | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. | 2003 | Blood | pmid:12511413 |
Wang ZM et al. | Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. | 2002 | Ai Zheng | pmid:12508652 |
Fahrner JA et al. | Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. | 2002 | Cancer Res. | pmid:12499261 |
Yamashita K et al. | Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. | 2002 | Cancer Cell | pmid:12498717 |
Thomas RM et al. | Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen. | 2003 | J. Immunol. | pmid:12496403 |
Yamashita Y et al. | Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. | 2003 | Int. J. Cancer | pmid:12494463 |
Lietz M et al. | RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. | 2003 | Eur. J. Biochem. | pmid:12492469 |
Zarnegar R et al. | Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. | 2002 | Surgery | pmid:12490845 |
Dogra SC et al. | Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. | 2003 | Mol. Pharmacol. | pmid:12488538 |
Boutillier AL et al. | Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12485907 |
Im H et al. | Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. | 2002 | Biochemistry | pmid:12484752 |
Ding Z et al. | Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. | 2003 | Mol. Cell. Biol. | pmid:12482978 |
Kondo Y et al. | Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. | 2003 | Mol. Cell. Biol. | pmid:12482974 |
Blagosklonny MV et al. | Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. | 2002 | Mol. Cancer Ther. | pmid:12481415 |
Strait KA et al. | Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. | 2002 | Mol. Cancer Ther. | pmid:12479699 |
Gusterson RJ et al. | The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. | 2003 | J. Biol. Chem. | pmid:12477714 |
Scott GK et al. | Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. | 2002 | Mol. Cancer Ther. | pmid:12477051 |
Iwata K et al. | Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470611 |
Chen T et al. | Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. | 2002 | Arch. Biochem. Biophys. | pmid:12464268 |
Duharcourt S and Yao MC | Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. | 2002 | Eukaryotic Cell | pmid:12455963 |
Marin-Husstege M et al. | Histone deacetylase activity is necessary for oligodendrocyte lineage progression. | 2002 | J. Neurosci. | pmid:12451133 |
Guo WH et al. | Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. | 2002 | Oncogene | pmid:12447699 |
Rombouts K et al. | Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. | 2002 | J. Hepatol. | pmid:12445420 |
Takechi S et al. | Chicken HDAC2 down-regulates IgM light chain gene promoter activity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437980 |
Yáñez RJ and Porter AC | A chromosomal position effect on gene targeting in human cells. | 2002 | Nucleic Acids Res. | pmid:12433992 |
Elaut G et al. | Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:12433798 |
Kim JY et al. | Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation. | 2002 | Anal. Chem. | pmid:12433071 |
Zhang J et al. | Establishment of transcriptional competence in early and late S phase. | 2002 | Nature | pmid:12432398 |
Ghoshal K et al. | Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. | 2002 | Mol. Cell. Biol. | pmid:12417732 |
Choy JS and Kron SJ | NuA4 subunit Yng2 function in intra-S-phase DNA damage response. | 2002 | Mol. Cell. Biol. | pmid:12417725 |
Wilson AJ et al. | Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. | 2002 | Cancer Res. | pmid:12414619 |
Travers H et al. | Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. | 2002 | Exp. Cell Res. | pmid:12413881 |
Rössig L et al. | Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. | 2002 | Circ. Res. | pmid:12411399 |
Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
Chen Z et al. | Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. | 2002 | Cancer Lett. | pmid:12406558 |
Bereshchenko OR et al. | Acetylation inactivates the transcriptional repressor BCL6. | 2002 | Nat. Genet. | pmid:12402037 |
Yang L et al. | An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. | 2003 | Biochem. J. | pmid:12398767 |
Witt O et al. | Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. | 2003 | Blood | pmid:12393499 |
Westendorf JJ et al. | Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. | 2002 | Mol. Cell. Biol. | pmid:12391164 |
Hauser C et al. | Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. | 2002 | Mol. Cell. Biol. | pmid:12391151 |
Harada K et al. | Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. | 2002 | Cancer Res. | pmid:12384554 |