trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with trichostatin A?
Related references are published most in these journals:
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim YB et al. | Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. | 2000 | J. Antibiot. | pmid:11132966 |
| Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
| Johnson CA et al. | Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. | 2001 | J. Biol. Chem. | pmid:11136718 |
| Nakayama T et al. | Epigenetic regulation of androgen receptor gene expression in human prostate cancers. | 2000 | Lab. Invest. | pmid:11140692 |
| Eickhoff B et al. | Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. | 2000 | Biol. Chem. | pmid:11154071 |
| Yang X et al. | Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. | 2000 | Cancer Res. | pmid:11156387 |
| Chang YC et al. | Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene. | 2001 | Mol. Cell. Biol. | pmid:11158299 |
| Newell-Price J et al. | The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression. | 2001 | Mol. Endocrinol. | pmid:11158338 |
| Kamitani H et al. | Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. | 2001 | Carcinogenesis | pmid:11159758 |
| Meier JL | Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator. | 2001 | J. Virol. | pmid:11160656 |
| Kuusisto E et al. | Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162503 |
| Grandjean V et al. | Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain. | 2001 | FEBS Lett. | pmid:11163765 |
| Lizcano F et al. | Cell type-specific roles of histone deacetylase in TR ligand-independent transcriptional repression. | 2001 | Mol. Cell. Endocrinol. | pmid:11165035 |
| Wu JT et al. | Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11171632 |
| Taddei A et al. | Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. | 2001 | Nat. Cell Biol. | pmid:11175742 |
| Ferrara FF et al. | Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. | 2001 | Cancer Res. | pmid:11196162 |
| Yang H et al. | Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11208539 |
| Griswold MD et al. | Mechanisms involved in the homologous down-regulation of transcription of the follicle-stimulating hormone receptor gene in Sertoli cells. | 2001 | Mol. Cell. Endocrinol. | pmid:11223181 |
| Mishra N et al. | Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226290 |
| Shestakova E et al. | Inhibition of histone deacetylation induces constitutive derepression of the beta interferon promoter and confers antiviral activity. | 2001 | J. Virol. | pmid:11238870 |