Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Flørenes VA et al. | Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. | 2004 | Melanoma Res. | pmid:15179185 |
Ahn MR et al. | Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. | 2004 | Arch. Pharm. Res. | pmid:15180307 |
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Kato N et al. | Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. | 2004 | Cell Death Differ. | pmid:15153943 |
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Wang LG et al. | Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. | 2004 | Oncogene | pmid:15156193 |
Romanski A et al. | Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. | 2004 | Haematologica | pmid:15075075 |
Bayart E et al. | A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. | 2004 | Cancer Res. | pmid:15604258 |
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Lasa A et al. | MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. | 2004 | Leukemia | pmid:15103390 |
Yokota T et al. | Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. | 2004 | Oncogene | pmid:15107822 |
McGarry LC et al. | Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes. | 2004 | Oncogene | pmid:15107823 |
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Tong X et al. | Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15063780 |
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Arapshian A et al. | Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. | 2004 | Mol. Cancer | pmid:15113415 |
Mizukami T et al. | Effects of trichostatin a, a histone deacetylase inhibitor, on mouse gonadal development in vitro. | 2004 | J. Reprod. Dev. | pmid:15118250 |
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Reifenberger J et al. | Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. | 2004 | Int. J. Cancer | pmid:14961576 |
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Vaisburg A et al. | (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14684344 |
Lu XC et al. | [Effect of inhibitors for demethylation and histone deacetylase on proliferation of cell line K562 and expression of tumor related genes]. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:14989767 |
Nojima H et al. | Increase in DNA methylation downregulates conceptus interferon-tau gene expression. | 2004 | Mol. Reprod. Dev. | pmid:14991730 |
Leu TH et al. | Participation of p97Eps8 in Src-mediated transformation. | 2004 | J. Biol. Chem. | pmid:14699156 |
Chua YL et al. | Microarray analysis of chromatin-immunoprecipitated DNA identifies specific regions of tobacco genes associated with acetylated histones. | 2004 | Plant J. | pmid:14996214 |
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Pagans S et al. | Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. | 2004 | J. Biol. Chem. | pmid:14701830 |
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Hwang CK et al. | Transcriptional regulation of mouse mu opioid receptor gene by PU.1. | 2004 | J. Biol. Chem. | pmid:14998994 |
Brush MH et al. | Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. | 2004 | J. Biol. Chem. | pmid:14670976 |
Gray SG et al. | Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. | 2004 | Int. J. Oncol. | pmid:15010814 |
Lee JH et al. | Histone deacetylase activity is required for embryonic stem cell differentiation. | 2004 | Genesis | pmid:14755802 |
Lemonde S et al. | Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. | 2004 | J. Neurochem. | pmid:14756806 |
Aapola U et al. | Epigenetic modifications affect Dnmt3L expression. | 2004 | Biochem. J. | pmid:15015937 |
Hattori N et al. | Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. | 2004 | J. Biol. Chem. | pmid:14761969 |
Burton GR et al. | Microarray analysis of differentiation-specific gene expression during 3T3-L1 adipogenesis. | 2004 | Gene | pmid:15033539 |
David GL et al. | MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine. | 2004 | Cancer Biol. Ther. | pmid:15034303 |
Liu X et al. | Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. | 2004 | Biochem. Pharmacol. | pmid:15041467 |
Elaut G et al. | Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors. | 2004 | Altern Lab Anim | pmid:23577441 |
Mai A et al. | 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. | 2004 | J. Med. Chem. | pmid:14971890 |
Milhem M et al. | Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A. | 2004 | Blood | pmid:14976039 |
Agostinho M et al. | Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis. | 2004 | Mol. Biol. Cell | pmid:14978217 |
Cao H et al. | Induction of human gamma globin gene expression by histone deacetylase inhibitors. | 2004 | Blood | pmid:12920038 |
Sarg B et al. | Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation. | 2004 | J. Biol. Chem. | pmid:15456746 |
Nan X et al. | Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15465025 |
Spenger A et al. | Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. | 2004 | Protein Expr. Purif. | pmid:15477077 |
Yee SB et al. | Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. | 2004 | Int. J. Oncol. | pmid:15492835 |
Young JC et al. | Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. | 2004 | Cytotherapy | pmid:16146885 |
Um SJ et al. | In vitro antitumor potential of 4-BPRE, a butyryl aminophenyl ester of retinoic acid: role of the butyryl group. | 2004 | Oncol. Rep. | pmid:14767528 |
Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
Fan X et al. | Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. | 2004 | J. Cell. Biochem. | pmid:15389882 |
Alikhani-Koopaei R et al. | Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. | 2004 | J. Clin. Invest. | pmid:15489962 |
Marsili G et al. | Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659847 |
Keen JC et al. | Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells. | 2004 | Cancer Biol. Ther. | pmid:15662126 |
Ding W | [A histone deacetylase inhibitor and tumor suppressing gene p53 induction synergistically induce apoptosis of cancer cells]. | 2004 | Hokkaido Igaku Zasshi | pmid:15675303 |
Yamashita Y et al. | cDNA microarray analysis in hepatocyte differentiation in Huh 7 cells. | 2004 | Cell Transplant | pmid:15690981 |
Thelen P et al. | Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. | 2004 | Int. J. Oncol. | pmid:14654937 |
Zhang Y et al. | Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. | 2004 | Radiat. Res. | pmid:15161353 |
Glenn MP et al. | Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. | 2004 | J. Med. Chem. | pmid:15163181 |
Ronai D et al. | The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature. | 2004 | Genetics | pmid:15166165 |
Zhang X et al. | Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. | 2004 | Mol. Cell. Biol. | pmid:15169878 |
Ishiguro K and Sartorelli AC | Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. | 2004 | Eur. J. Biochem. | pmid:15182353 |
Brieger A et al. | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | 2004 | Biochem. Pharmacol. | pmid:15183120 |
Chaturvedi V et al. | Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53. | 2004 | J. Cell. Physiol. | pmid:14584049 |
Laeng P et al. | The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. | 2004 | J. Neurochem. | pmid:15379904 |
Kim MK and Carroll WL | Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2. | 2004 | Cancer | pmid:15382088 |
Tang XX et al. | Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma. | 2004 | Clin. Cancer Res. | pmid:15355914 |
Yokota T et al. | Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene. | 2004 | FEBS Lett. | pmid:15358560 |
Boehrer S et al. | In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. | 2004 | Leuk. Lymphoma | pmid:15359646 |
Vaghefi H and Neet KE | Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. | 2004 | Oncogene | pmid:15361854 |
Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
Tao D et al. | Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. | 2004 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:15346199 |
Korkmaz CG et al. | Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants. | 2004 | J. Endocrinol. | pmid:15350180 |
Akimoto T | [Potentiation of radiation-induced cell killing by histone deacetylase inhibitor]. | 2004 | Nippon Rinsho | pmid:15283155 |
Joung KE et al. | Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15283467 |
Kang J et al. | Synergistic killing of human leukemia cells by antioxidants and trichostatin A. | 2004 | Cancer Chemother. Pharmacol. | pmid:15248029 |
Jin B and Ryu DY | Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes. | 2004 | J. Biochem. Mol. Toxicol. | pmid:15252868 |
Gilchrist S et al. | Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. | 2004 | Chromosome Res. | pmid:15254368 |
Aggarwal BD and Calvi BR | Chromatin regulates origin activity in Drosophila follicle cells. | 2004 | Nature | pmid:15254542 |
Sanderson L et al. | Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. | 2004 | Drug Metab. Dispos. | pmid:15269190 |
Levenson JM et al. | Regulation of histone acetylation during memory formation in the hippocampus. | 2004 | J. Biol. Chem. | pmid:15273246 |
Li X et al. | Regulation of histone acetylation and apoptosis by trichostatin in HL-60 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15791844 |
Liu C and Xu D | Inhibition of histone deacetylases. | 2004 | Methods Mol. Biol. | pmid:15273406 |
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Vanhaecke T et al. | Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures. | 2004 | Biochem. Pharmacol. | pmid:15276083 |
ChuÄkin IA et al. | [Transcription of c-fos gene and DNA binding activity of transcription factor AP-1 increase upon differentiation of mouse F9 teratocarcinoma cells]. | 2004 | Tsitologiia | pmid:15747838 |
Korzus E et al. | CBP histone acetyltransferase activity is a critical component of memory consolidation. | 2004 | Neuron | pmid:15207240 |
Ishihara K et al. | Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils. | 2004 | Br. J. Pharmacol. | pmid:15210580 |
Marengo E et al. | Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. | 2004 | Anal Bioanal Chem | pmid:15257427 |
Schauber J et al. | Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. | 2004 | Mol. Immunol. | pmid:15261456 |
De La Fuente R et al. | ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. | 2004 | Dev. Biol. | pmid:15242786 |
Alao JP et al. | Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. | 2004 | Clin. Cancer Res. | pmid:15585645 |
Emionite L et al. | Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines. | 2004 Nov-Dec | Anticancer Res. | pmid:15736447 |
Karasawa Y and Okisaka S | Inhibition of histone deacetylation by butyrate induces morphological changes in Y79 retinoblastoma cells. | 2004 Nov-Dec | Jpn. J. Ophthalmol. | pmid:15592778 |