trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Pulmonary Fibrosis D011658 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nasal Polyps D009298 26 associated lipids
Glioblastoma D005909 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Cecconi D et al. Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. 2009 Proteomics pmid:19294695
Ikeda S et al. Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts. 2009 Zygote pmid:19356267
Morita K et al. Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. 2009 J. Neurosci. Res. pmid:19360904
von Burstin J et al. E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. 2009 Gastroenterology pmid:19362090
Yang X et al. CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. 2009 PLoS ONE pmid:19340297
Slattery EL et al. Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. 2009 J. Assoc. Res. Otolaryngol. pmid:19340485
Vilar E et al. Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. 2009 Clin. Cancer Res. pmid:19351759
Lu SC et al. The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. 2009 Am. J. Physiol., Cell Physiol. pmid:19279235
Luo SF et al. Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. 2009 Toxicol. Appl. Pharmacol. pmid:19281832
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Ueda JY et al. JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. 2009 J. Antibiot. pmid:19300468
Noro R et al. The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application. 2009 J Nippon Med Sch pmid:19305113
Glenn DJ et al. Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. 2009 Hypertension pmid:19139378
Deng G et al. Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. 2009 Clin. Cancer Res. pmid:19223499
Dombrowsky H et al. Conserved responses to trichostatin A in rodent lungs exposed to endotoxin or stretch. 2009 Pulm Pharmacol Ther pmid:19744573
Dandrea M et al. MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. 2009 Nucleic Acids Res. pmid:19745053
Lugrin J et al. Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. 2009 Biochim. Biophys. Acta pmid:19747950
Cervera RP et al. Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. 2009 Theriogenology pmid:19765811
Diplas AI et al. Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. 2009 Nucleic Acids Res. pmid:19767614
Ma XX et al. Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. 2009 Eur. J. Gynaecol. Oncol. pmid:19697617
Izawa M et al. Inhibition of histone deacetylase causes reduction of appressorium formation in the rice blast fungus Magnaporthe oryzae. 2009 J. Gen. Appl. Microbiol. pmid:20118613
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Samuni Y et al. The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation. 2009 Free Radic. Biol. Med. pmid:19447172
Gavin DP et al. Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. 2009 J Psychiatry Neurosci pmid:19448855
Astrand C et al. Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter. 2009 Exp. Cell Res. pmid:19463811
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Hauswald S et al. Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. 2009 Clin. Cancer Res. pmid:19458058
Arce L et al. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. 2009 BMC Cancer pmid:19460168
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Ku WC et al. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. 2009 Mol. Cell Proteomics pmid:19505873
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Bonetto A et al. Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice. 2009 Curr Cancer Drug Targets pmid:19508174
Chang J et al. The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. 2009 J. Cell. Sci. pmid:19509051
Nakajima S et al. Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. 2009 Oncol. Rep. pmid:19513516
Ma XL et al. [Construction of anti-sense cDNA library of human breast cancer cells during apoptosis induced by trichostatin A and preliminary screening of essential genes]. 2009 Zhonghua Yi Xue Za Zhi pmid:19567099
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Rahim R and Strobl JS Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. 2009 Anticancer Drugs pmid:19584707
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Giustiniani J et al. Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. 2009 Exp. Cell Res. pmid:19632222
Chandrasekaran S et al. Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. 2009 FASEB J. pmid:19638401
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Łuczak MW and Jagodziński PP Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells. 2009 Biomed. Pharmacother. pmid:18602794
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Tsuji Y et al. The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2'-deoxycytidine. 2009 Zygote pmid:19175955
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