| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Leukemia, Myelomonocytic, Acute | D015479 | 6 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Polycystic Kidney, Autosomal Dominant | D016891 | 6 associated lipids |
| Cicatrix, Hypertrophic | D017439 | 4 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dar RD et al. | Transcriptional burst frequency and burst size are equally modulated across the human genome. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23064634 |
| Grisolano JL et al. | An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12881486 |
| Slack MD et al. | Characterizing heterogeneous cellular responses to perturbations. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19052231 |
| Chen WY and Townes TM | Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10618426 |
| Zhang L et al. | Small molecule regulators of autophagy identified by an image-based high-throughput screen. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18024584 |
| Cao Y et al. | Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19966229 |
| Porter NJ et al. | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29203661 |
| Thompson EM et al. | Real time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7877974 |
| Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
| Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
| Duffy S et al. | Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27551064 |
| Richon VM et al. | A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501205 |
| Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
| Crump NT et al. | Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21518915 |
| Selker EU | Trichostatin A causes selective loss of DNA methylation in Neurospora. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689097 |
| Saito A et al. | A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200307 |
| Tavera-Mendoza LE et al. | Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18550844 |
| Monte M et al. | MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16847267 |
| Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
| Subramanian C et al. | Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15778293 |