| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cicatrix, Hypertrophic | D017439 | 4 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Nasopharyngeal Neoplasms | D009303 | 4 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Progeria | D011371 | 3 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dowling DP et al. | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. | 2008 | Biochemistry | pmid:19053282 |
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| Gray SG et al. | Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. | 2008 | Clin Lung Cancer | pmid:19073520 |
| Zhu K et al. | Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. | 2008 | Arch. Gynecol. Obstet. | pmid:17680259 |
| Nair S et al. | Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. | 2008 | Pharm. Res. | pmid:17657594 |
| Zhou Q et al. | Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. | 2008 | Mol. Vis. | pmid:19122829 |
| Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP]. | 2008 | Ai Zheng | pmid:19079988 |
| Usami M et al. | Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. | 2008 | Nutr Res | pmid:19083427 |
| Krämer OH et al. | Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. | 2008 | Oncogene | pmid:17653085 |
| Tanaka M et al. | The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination. | 2008 | Plant Physiol. | pmid:18024558 |
| Domingo-Domènech J et al. | Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. | 2008 | Breast Cancer Res. Treat. | pmid:18064564 |
| Hajji N et al. | Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. | 2008 | Oncogene | pmid:18071312 |
| Walton TJ et al. | DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. | 2008 | Prostate | pmid:18092350 |
| Arany I et al. | Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18094030 |
| Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
| Nasu Y et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. | 2008 | Osteoarthr. Cartil. | pmid:18226559 |
| Lim HG et al. | Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. | 2008 | Mol. Ther. | pmid:18227841 |
| Ruau D et al. | Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. | 2008 | Stem Cells | pmid:18203677 |
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| Hamner JB et al. | The efficacy of combination therapy using adeno-associated virus--interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. | 2008 | J. Pediatr. Surg. | pmid:18206478 |
| Duhamel M et al. | Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. | 2008 | FEBS Lett. | pmid:18206652 |
| Joseph RA et al. | Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking. | 2008 | Hepatology | pmid:18161881 |
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| Campanero MR et al. | The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. | 2008 | Oncogene | pmid:17724474 |
| Manning J et al. | Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. | 2008 | Immunology | pmid:17725605 |
| Pan J et al. | TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells. | 2008 | Mol. Cancer Res. | pmid:18505930 |
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| Dalgard CL et al. | Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. | 2008 | Clin. Cancer Res. | pmid:18483379 |
| Brown CR et al. | Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. | 2008 | Genes Dev. | pmid:18316479 |
| Fleury L et al. | Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. | 2008 | Oncogene | pmid:18317449 |
| Fantini D et al. | APE1/Ref-1 regulates PTEN expression mediated by Egr-1. | 2008 | Free Radic. Res. | pmid:18324520 |
| Kang JH et al. | CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. | 2008 | J. Cell. Biochem. | pmid:18275041 |
| Zhang Y et al. | Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release. | 2008 | J. Biol. Chem. | pmid:18596044 |
| Oliva J et al. | Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. | 2008 | Exp. Mol. Pathol. | pmid:18280469 |
| Xu LN et al. | Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines. | 2008 | World J. Gastroenterol. | pmid:18442209 |
| Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
| Yu C et al. | Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. | 2008 | Neuro-oncology | pmid:18445700 |
| Yu WP et al. | Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells. | 2008 | Cell Prolif. | pmid:18211287 |
| Jensen TJ et al. | Epigenetic remodeling during arsenical-induced malignant transformation. | 2008 | Carcinogenesis | pmid:18448484 |
| Kikuno N et al. | Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. | 2008 | Int. J. Cancer | pmid:18431742 |
| van West P et al. | Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling. | 2008 | Microbiology (Reading, Engl.) | pmid:18451057 |
| Zhang HJ et al. | Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. | 2008 | Placenta | pmid:18440631 |
| Liu Z et al. | Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells. | 2008 | Oncol. Rep. | pmid:18575731 |
| Meja KK et al. | Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18421014 |
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| Sun Y et al. | Modulation of transcription parameters in glucocorticoid receptor-mediated repression. | 2008 | Mol. Cell. Endocrinol. | pmid:18583028 |
| Tshuikina M et al. | Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. | 2008 | Exp. Hematol. | pmid:18922617 |
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| Wu X et al. | Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development. | 2008 | Anim. Biotechnol. | pmid:18855246 |
| Lindström TM et al. | Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells. | 2008 | Mol. Pharmacol. | pmid:18375836 |
| Kato A et al. | Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. | 2008 | Exp. Cell Res. | pmid:18588874 |
| Li J et al. | High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos. | 2008 | Theriogenology | pmid:18573521 |
| Xu ZM et al. | The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage. | 2008 | BMB Rep | pmid:18377727 |
| Chen CJ et al. | Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells. | 2008 | Eur. J. Pharmacol. | pmid:18590721 |
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| Zhu X et al. | Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18544619 |
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| Kim B et al. | Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. | 2008 | Eur. J. Pharmacol. | pmid:18550052 |
| Hämäläinen M et al. | Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors. | 2008 | Pulm Pharmacol Ther | pmid:17913526 |
| Svechnikova I et al. | HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. | 2008 | Int. J. Oncol. | pmid:18360709 |
| Mukherjee P et al. | Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. | 2008 | Bioorg. Med. Chem. | pmid:18362073 |
| Pryzbylkowski P et al. | Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. | 2008 | Breast Cancer Res. Treat. | pmid:17891453 |
| Brown SL et al. | Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. | 2008 | Radiat. Res. | pmid:18363436 |
| Vrbova G | Spinal muscular atrophy: motoneurone or muscle disease? | 2008 | Neuromuscul. Disord. | pmid:18365338 |
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| Liu PY et al. | Modulation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa Cells. | 2008 | Mol. Cancer Res. | pmid:18644983 |
| Liu TC et al. | Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. | 2008 | Mol. Ther. | pmid:18388912 |
| Roy S et al. | Array-based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18645003 |
| Hayakawa F et al. | Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis. | 2008 | J. Biol. Chem. | pmid:18621739 |
| Reilly CM et al. | The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. | 2008 | J. Autoimmun. | pmid:18650065 |
| Pluemsampant S et al. | Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. | 2008 | Int. J. Cancer | pmid:17935135 |
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| Bosisio D et al. | Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. | 2008 | J. Leukoc. Biol. | pmid:18780875 |
| Yang L et al. | [Effect of decitabine combined with Trichostatin A on MDS cell line SKM-1 in vitro]. | 2008 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18718068 |
| Zou XM et al. | Gastric cancer cell lines induced by trichostatin A. | 2008 | World J. Gastroenterol. | pmid:18720545 |
| Nishino N et al. | Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides. | 2008 | Bioorg. Med. Chem. | pmid:17900911 |
| Duan H et al. | Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. | 2008 | Oncogene | pmid:18695675 |
| Ding X et al. | Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A. | 2008 | Theriogenology | pmid:18556056 |
| Jia J and Chen J | Histone hyperacetylation is involved in the quercetin-induced human leukemia cell death. | 2008 | Pharmazie | pmid:18557424 |
| Narver HL et al. | Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. | 2008 | Ann. Neurol. | pmid:18661558 |
| Yu J et al. | Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. | 2008 | Hepatology | pmid:18666234 |
| Liu F et al. | Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. | 2008 | J. Mol. Cell. Cardiol. | pmid:18926829 |
| Gu Z et al. | Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas. | 2008 | Genes Genet. Syst. | pmid:18931460 |
| Yoshioka H et al. | Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. | 2008 | J. Biol. Chem. | pmid:18801729 |
| Wu Y and Guo SW | Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. | 2008 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17376583 |
| Jin B et al. | DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. | 2008 | Hum. Mol. Genet. | pmid:18029387 |
| Gan Y et al. | Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:17996726 |
| Han JQ et al. | [Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18822204 |
| Lee EJ et al. | Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. | 2008 | Int. J. Oncol. | pmid:18813790 |
| Van Wagoner DR and Nattel S | Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. | 2008 | J. Mol. Cell. Cardiol. | pmid:18817781 |
| Pellicciotta I et al. | Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. | 2008 | Cancer Res. | pmid:18829567 |
| Hitchler MJ et al. | Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells. | 2008 | Free Radic. Biol. Med. | pmid:18845242 |