trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Rosborough BR et al. Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. 2012 J. Leukoc. Biol. pmid:22028329
Li H et al. Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. 2012 Diabetes pmid:22338096
Sakuma Y et al. WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. 2012 Lab. Invest. pmid:22157722
Schor IE et al. Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. 2012 PLoS ONE pmid:23152763
Gan L et al. Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. 2012 PLoS ONE pmid:22761896
Orlova DY et al. Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. 2012 J. Cell. Biochem. pmid:22644811
Pufahl L et al. Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. 2012 J. Cell. Mol. Med. pmid:21883892
Mostovich LA et al. Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. 2011 Sep-Oct Cell Adh Migr pmid:21975548
Stepanek I et al. Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. 2011 Oct-Dec J. Biol. Regul. Homeost. Agents pmid:22217985
Kee HJ et al. Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. 2011 Nov-Dec Vascul. Pharmacol. pmid:21763782
Meng CF et al. DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. 2011 Nov-Dec Mol Med Rep pmid:21850374
Cowell IG et al. Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. 2011 Jan-Feb Nucleus pmid:21647300
Halder SK et al. Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. 2011 Neoplasia pmid:22028617
Bo F et al. Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. 2011 Zygote pmid:20569515
Hutt DM et al. Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. 2011 ACS Med Chem Lett pmid:21984958
Majumdar G et al. Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. 2011 Physiol. Genomics pmid:21954451
Tsai KW et al. Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. 2011 Int. J. Cancer pmid:21960261
Ohtani K et al. Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. 2011 Circ. Res. pmid:21980126
Hagiwara H et al. Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. 2011 Biochem. Biophys. Res. Commun. pmid:22019851
Kaichi S et al. Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. 2011 J. Cell. Physiol. pmid:20665673
Pichugin A et al. Ring-like distribution of constitutive heterochromatin in bovine senescent cells. 2011 PLoS ONE pmid:22132080
Wang JP et al. Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression. 2011 Differentiation pmid:21074928
Oyer JA et al. Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation. 2011 Mutat. Res. pmid:21035468
Pabba C et al. Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. 2011 Bioorg. Med. Chem. Lett. pmid:21109435
Vrzal R et al. Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia? 2011 Toxicol. Lett. pmid:21115105
Coleman SL et al. Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. 2011 Eur J Nutr pmid:21046125
Marrazzo A et al. Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. 2011 Eur J Med Chem pmid:21055848
Gao A et al. Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression. 2011 Cell Biol. Int. pmid:21143203
Wang YS et al. Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. 2011 Theriogenology pmid:21144561
Shiratsuki S et al. Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. 2011 Theriogenology pmid:21144563
Poljakova J et al. Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. 2011 Neuro Endocrinol. Lett. pmid:22167207
Williams PJ et al. HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. 2011 Ann. N. Y. Acad. Sci. pmid:22172035
Johansson AS et al. Valproic acid phase shifts the rhythmic expression of Period2::Luciferase. 2011 J. Biol. Rhythms pmid:22215612
Hawk JD et al. Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. 2011 Learn. Mem. pmid:21576516
Dong X et al. Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. 2011 Endocr. Relat. Cancer pmid:21367844
Zhu QY et al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. 2011 Cell Death Dis pmid:21368888
Hsu YF et al. p53 in trichostatin A induced C6 glioma cell death. 2011 Biochim. Biophys. Acta pmid:21376104
Ryhänen T et al. Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells. 2011 J. Biomed. Biotechnol. pmid:20981255
Briggs B et al. Photosensitization by iodinated DNA minor groove binding ligands: Evaluation of DNA double-strand break induction and repair. 2011 J. Photochem. Photobiol. B, Biol. pmid:21440453
Seitz V et al. Classical Hodgkin's lymphoma shows epigenetic features of abortive plasma cell differentiation. 2011 Haematologica pmid:21393330
Agudelo M et al. Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). 2011 Alcohol. Clin. Exp. Res. pmid:21447001
Zhang Y et al. ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. 2011 Toxicon pmid:21419152
WEI Q et al. [Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. 2011 Nan Fang Yi Ke Da Xue Xue Bao pmid:21421475
Jergil M et al. Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. 2011 Toxicol. Sci. pmid:21427059
Diao JS et al. Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. 2011 Arch. Dermatol. Res. pmid:21400246
Zhang J et al. Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. 2011 Endocrinology pmid:21406501
Kawasaki H et al. Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. 2011 PLoS ONE pmid:21407806
Fang Y et al. Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. 2011 Cancer Invest. pmid:21345073
Qiu GH et al. Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. 2011 Mol. Ther. pmid:21540836
Kong Q et al. Effect of trichostatin A and 5-Aza-2'-deoxycytidine on transgene reactivation and epigenetic modification in transgenic pig fibroblast cells. 2011 Mol. Cell. Biochem. pmid:21541675
Park JW et al. Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. 2011 J. Nat. Prod. pmid:21504214
Matoba S et al. RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:22065773
Bolleyn J et al. Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. 2011 Toxicol In Vitro pmid:21513791
Rajasingh J et al. Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. 2011 PLoS ONE pmid:21799893
Ramsey MR et al. Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. 2011 Cancer Res. pmid:21527555
Klawitter M et al. Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. 2011 J Negat Results Biomed pmid:21801383
Nishikata I et al. Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation. 2011 Oncogene pmid:21516122
Tong Y et al. PTTG1 attenuates drug-induced cellular senescence. 2011 PLoS ONE pmid:21858218
Crump NT et al. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21518915
Bui HT et al. Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. 2011 Biol. Reprod. pmid:21753193
Fortson WS et al. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. 2011 Int. J. Oncol. pmid:21519790
Huang KT et al. Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer. 2011 Breast Cancer Res. Treat. pmid:21755341
Inoue H et al. Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: roles of epigenetic modifications in transcriptional regulation. 2011 Mol. Cell. Endocrinol. pmid:21756973
Wang Y et al. The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. 2011 Cell Reprogram pmid:21486115
Watanabe Y and Tanaka M p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. 2011 J. Cell. Sci. pmid:21771882
Hattori N et al. Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 2011 Cancer Sci. pmid:21489049
Miller L et al. Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. 2011 Physiol. Behav. pmid:21463644
Tost J et al. Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. 2011 Epigenetics pmid:21775817
Law AY et al. Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. 2011 J. Cell. Biochem. pmid:21465530
Blanquart C et al. Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. 2011 Curr Cancer Drug Targets pmid:21762083
Wan Y et al. Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. 2011 FEBS Lett. pmid:21763693
Hu Y et al. Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. 2011 PLoS ONE pmid:21811564
Robers MB et al. Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. 2011 Mol Biosyst pmid:20931131
Crandall JE et al. Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. 2011 J. Neurochem. pmid:21895658
Bogaard HJ et al. Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. 2011 Am. J. Respir. Crit. Care Med. pmid:21297075
Jafarpour F et al. Somatic cell-induced hyperacetylation, but not hypomethylation, positively and reversibly affects the efficiency of in vitro cloned blastocyst production in cattle. 2011 Cell Reprogram pmid:21919704
Furumai R et al. Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment. 2011 Cancer Sci. pmid:21299717
Chen S et al. [Effect of trichostatin alone and combination with imatinb on the proliferation and apoptosis of the K562R cells]. 2011 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:21937807
Cai HH et al. Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. 2011 HBPD INT pmid:21269942
Lee SC et al. HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. 2011 J. Biomed. Biotechnol. pmid:21253530
Chen WP et al. Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. 2011 Rheumatol. Int. pmid:20390279
Yoon CY et al. The histone deacetylase inhibitor trichostatin A synergistically resensitizes a cisplatin resistant human bladder cancer cell line. 2011 J. Urol. pmid:21255805
Choi E et al. Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. 2011 Bioorg. Med. Chem. Lett. pmid:21256006
Mizuno S et al. Inhibition of histone deacetylase causes emphysema. 2011 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21224215
Hai T et al. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. 2011 Cell Reprogram pmid:21241188
Zou CF et al. Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. 2011 BMC Cancer pmid:21244707
Nakamura J et al. Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. 2011 Am. J. Pathol. pmid:21281785
Chen MY et al. Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. 2011 Cancer pmid:21491416
Farinas B and Mas P Functional implication of the MYB transcription factor RVE8/LCL5 in the circadian control of histone acetylation. 2011 Plant J. pmid:21205033
Muralidhar SA et al. Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells. 2011 J. Biol. Chem. pmid:21078662
Chakravarty G et al. Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. 2011 Cancer Biol. Ther. pmid:21084857
Meng Y et al. Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma. 2011 Dig. Dis. Sci. pmid:21567192
Puppin C et al. Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines. 2011 Oncol. Rep. pmid:21617864
Shu G et al. Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. 2011 Cell Death Differ. pmid:21546906
Vojdani Z et al. Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract. 2011 Hum. Cell pmid:21547694
Neelarapu R et al. Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. 2011 J. Med. Chem. pmid:21548582
Vassiliev I et al. Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A. 2011 Cell Reprogram pmid:21548828
Ververis K et al. Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. 2011 Cell. Mol. Life Sci. pmid:21584806
Misaki K et al. Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. 2011 Arthritis Res. Ther. pmid:21592365
Selinger CI et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. 2011 J Thorac Oncol pmid:21597389