trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Sanyal S et al. Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. 2002 J. Biol. Chem. pmid:11705994
Inoue H et al. Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. 2002 Int. J. Mol. Med. pmid:11956660
Galasinski SC et al. Global regulation of post-translational modifications on core histones. 2002 J. Biol. Chem. pmid:11709551
Stimson KM and Vertino PM Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. 2002 J. Biol. Chem. pmid:11733524
Chen T et al. Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. 2002 Arch. Biochem. Biophys. pmid:12464268
Rombouts K et al. Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. 2002 J. Hepatol. pmid:12445420
Guo WH et al. Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. 2002 Oncogene pmid:12447699
Marin-Husstege M et al. Histone deacetylase activity is necessary for oligodendrocyte lineage progression. 2002 J. Neurosci. pmid:12451133
Wang ZM et al. Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. 2002 Ai Zheng pmid:12508652
Duharcourt S and Yao MC Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. 2002 Eukaryotic Cell pmid:12455963
Strait KA et al. Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. 2002 Mol. Cancer Ther. pmid:12479699
Blagosklonny MV et al. Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. 2002 Mol. Cancer Ther. pmid:12481415
Roddie PH et al. Primary acute myeloid leukaemia blasts resistant to cytokine-induced differentiation to dendritic-like leukaemia cells can be forced to differentiate by the addition of bryostatin-1. 2002 Leukemia pmid:11840267
Taniura S et al. Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells. 2002 J. Biol. Chem. pmid:11877441
Heltweg B and Jung M A microplate reader-based nonisotopic histone deacetylase activity assay. 2002 Anal. Biochem. pmid:11878795
Kamitani H et al. Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced. 2002 Neuro-oncology pmid:11916500
Kishikawa S et al. Roles of histone acetylation in the Dnmt1 gene expression. 2002 Nucleic Acids Res. Suppl. pmid:12903179
Ginjala V et al. Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. 2002 J. Biol. Chem. pmid:11777900
Cabral AL et al. Regulation of the cellular prion protein gene expression depends on chromatin conformation. 2002 J. Biol. Chem. pmid:11739375
Park SH et al. Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. 2002 J. Biol. Chem. pmid:11744689
Suenaga M et al. Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. 2002 Int. J. Cancer pmid:11807787
Gurova KV et al. Expression of prostate specific antigen (PSA) is negatively regulated by p53. 2002 Oncogene pmid:11791186
Maeda Y et al. Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. 2002 Mol. Endocrinol. pmid:11818510
Fang D et al. Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. 2002 Nucleic Acids Res. pmid:12136092
Zschocke J et al. Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells. 2002 J. Biol. Chem. pmid:12138116
Yu Z et al. Histone deacetylases augment cytokine induction of the iNOS gene. 2002 J. Am. Soc. Nephrol. pmid:12138131
Li J et al. Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. 2002 Mol. Cell. Biol. pmid:12138181
Aapola U et al. Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. 2002 Nucleic Acids Res. pmid:12177302
Chang TH and Szabo E Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. 2002 Clin. Cancer Res. pmid:11948134
Ventura A et al. The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. 2002 J. Biol. Chem. pmid:11948181
Gradoville L et al. Protein kinase C-independent activation of the Epstein-Barr virus lytic cycle. 2002 J. Virol. pmid:11991990
Uesato S et al. Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group. 2002 Bioorg. Med. Chem. Lett. pmid:11992774
Nambiar MP et al. Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling. 2002 J. Cell. Biochem. pmid:11967985
Fu M et al. Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. 2002 Mol. Cell. Biol. pmid:11971970
Sirchia SM et al. Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. 2002 Cancer Res. pmid:11980632
Milutinovic S et al. Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification. 2002 J. Biol. Chem. pmid:11929879
Bharadwaj S and Prasad GL Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. 2002 Cancer Lett. pmid:12065096
Ito K et al. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12070353
Katula KS et al. Cell cycle specific changes in the human cyclin B1 gene regulatory region as revealed by response to trichostatin A. 2002 Arch. Biochem. Biophys. pmid:12054478
Wang XQ et al. Histone deacetylase inhibition results in decreased macrophage CD9 expression. 2002 Biochem. Biophys. Res. Commun. pmid:12056820
Rahmani M et al. The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process. 2002 Exp. Cell Res. pmid:12061815
Woo SH et al. Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. 2002 J. Med. Chem. pmid:12061890
Chen Y et al. On the epigenetic regulation of the human reelin promoter. 2002 Nucleic Acids Res. pmid:12087179
Zhang Y and Dufau ML Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. 2002 J. Biol. Chem. pmid:12091390
Danbara M et al. DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. 2002 Mol. Immunol. pmid:12044782
Lin HM et al. Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. 2002 J. Biol. Chem. pmid:12048199
Scott GK et al. Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. 2002 Mol. Cancer Ther. pmid:12477051
Quivy V et al. Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. 2002 J. Virol. pmid:12368351
Smith WL and Edlind TD Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. 2002 Antimicrob. Agents Chemother. pmid:12384361
Harada K et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. 2002 Cancer Res. pmid:12384554
Im H et al. Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. 2002 Biochemistry pmid:12484752
Zhang J et al. Establishment of transcriptional competence in early and late S phase. 2002 Nature pmid:12432398
Gong XQ and Li L Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. 2002 J. Biol. Chem. pmid:11809751
Rössig L et al. Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. 2002 Circ. Res. pmid:12411399
Hoshimoto A et al. Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. 2002 Br. J. Pharmacol. pmid:12010777
Sourlingas TG et al. The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. 2002 Jan-Mar Exp. Gerontol. pmid:11772521
Iwata K et al. Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. 2002 Jul-Aug Cell. Immunol. pmid:12470611
Noss KR et al. Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. 2002 May-Jun Anticancer Res. pmid:12168830
Rahman I et al. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. 2002 May-Jun Mol. Cell. Biochem. pmid:12162440
Boutillier AL et al. Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. 2003 J. Neurochem. pmid:12562525
Tomita K et al. The effect of oxidative stress on histone acetylation and IL-8 release. 2003 Biochem. Biophys. Res. Commun. pmid:12565901
Kim Y et al. Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. 2003 Oncogene pmid:12584561
Mishra N et al. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. 2003 J. Clin. Invest. pmid:12588892
Glaser KB et al. Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. 2003 Mol. Cancer Ther. pmid:12589032
Ailenberg M and Silverman M Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. 2003 Biochem. Biophys. Res. Commun. pmid:12604329
Ding Z et al. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. 2003 Mol. Cell. Biol. pmid:12482978
Obata T et al. Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. 2003 Clin. Cancer Res. pmid:14695142
Terui T et al. Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. 2003 Cancer Res. pmid:14695212
Liu A et al. Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. 2003 Glia pmid:14603467
Moreira JM et al. The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. 2003 BMC Cancer pmid:14606959
Remiszewski SW et al. N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824). 2003 J. Med. Chem. pmid:14521422
Noh EJ and Lee JS Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2-M transition. 2003 Biochem. Biophys. Res. Commun. pmid:14521905
Li C et al. Effect and comparison of sodium butyrate and trichostatin A on the proliferation/differentiation of K562. 2003 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:14526425
Grassi G et al. Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. 2003 Carcinogenesis pmid:12869421
Ammanamanchi S et al. Acetylated sp3 is a transcriptional activator. 2003 J. Biol. Chem. pmid:12837748
Krämer OH et al. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. 2003 EMBO J. pmid:12840003
Kishikawa S et al. Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. 2003 Nucleic Acids Res. Suppl. pmid:14510503
Wegener D et al. Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. 2003 Anal. Biochem. pmid:14511685
Kim MS et al. Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. 2003 Cancer Res. pmid:14612526
Miller TA et al. Histone deacetylase inhibitors. 2003 J. Med. Chem. pmid:14613312
Hitomi T et al. p15(INK4b) in HDAC inhibitor-induced growth arrest. 2003 FEBS Lett. pmid:14623092
Zhang Q et al. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. 2003 Toxicol. Appl. Pharmacol. pmid:14575637
Usenko T et al. Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. 2003 Oncogene pmid:14576829
Marks J et al. Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter. 2003 J. Biol. Chem. pmid:12791684
Valls E et al. The SV40 T antigen modulates CBP histone acetyltransferase activity. 2003 Nucleic Acids Res. pmid:12799439
Ferguson M et al. Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. 2003 Nucleic Acids Res. pmid:12799440
Ji Y et al. A multistep mechanism for the activation of rearrangement in the immune system. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12802019
Nemajerová A et al. Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. 2003 J. Hematother. Stem Cell Res. pmid:12804181
Park PH et al. Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. 2003 Biochem. Biophys. Res. Commun. pmid:12804592
Kim H et al. The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12816733
Klan N et al. Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. 2003 Biol. Chem. pmid:12817474
Yamada Y et al. Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. 2003 Cancer Sci. pmid:12824880
Van Ommeslaeghe K et al. Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. 2003 Bioorg. Med. Chem. Lett. pmid:12749885
Zhao S et al. Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. 2003 Cancer Res. pmid:12750289
Schauber J et al. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. 2003 Gut pmid:12692061
Rambhatla L et al. Generation of hepatocyte-like cells from human embryonic stem cells. 2003 Cell Transplant pmid:12693659
Lee SC et al. Activation of terminal B cell differentiation by inhibition of histone deacetylation. 2003 Mol. Immunol. pmid:12695118
Chandler SP et al. Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. 2003 BMC Mol. Biol. pmid:12659659
Zika E et al. Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. 2003 Mol. Cell. Biol. pmid:12697811
Mihaylova VT et al. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. 2003 Mol. Cell. Biol. pmid:12697826