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Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. |
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Mol. Cancer Ther. |
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The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. |
2003 |
J. Biol. Chem. |
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Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. |
2002 |
Mol. Cancer Ther. |
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Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. |
2002 |
Mol. Cancer Ther. |
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Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. |
2003 |
Mol. Cell. Biol. |
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Ding Z et al. |
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. |
2003 |
Mol. Cell. Biol. |
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Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. |
2002 |
Biochemistry |
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Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. |
2002 |
Ann. N. Y. Acad. Sci. |
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Dogra SC et al. |
Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. |
2003 |
Mol. Pharmacol. |
pmid:12488538
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Zarnegar R et al. |
Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. |
2002 |
Surgery |
pmid:12490845
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Lietz M et al. |
RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. |
2003 |
Eur. J. Biochem. |
pmid:12492469
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Yamashita Y et al. |
Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. |
2003 |
Int. J. Cancer |
pmid:12494463
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Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen. |
2003 |
J. Immunol. |
pmid:12496403
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Yamashita K et al. |
Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. |
2002 |
Cancer Cell |
pmid:12498717
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Fahrner JA et al. |
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. |
2002 |
Cancer Res. |
pmid:12499261
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Wang ZM et al. |
Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. |
2002 |
Ai Zheng |
pmid:12508652
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Rahman MM et al. |
Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. |
2003 |
Blood |
pmid:12511413
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Musikacharoen T et al. |
Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. |
2003 |
J. Biol. Chem. |
pmid:12511574
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Cell biology: Tubulin acetylation and cell motility. |
2003 |
Nature |
pmid:12529632
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Fernandes I et al. |
Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. |
2003 |
Mol. Cell |
pmid:12535528
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Upregulation of activin A gene by butyrate in human colon cancer cell lines. |
2003 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:12540370
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Kagoshima M et al. |
Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. |
2003 |
Biochem. Soc. Trans. |
pmid:12546654
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Teyssier C et al. |
Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. |
2003 |
Mol. Endocrinol. |
pmid:12554755
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Henderson C et al. |
Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). |
2003 |
J. Biol. Chem. |
pmid:12556448
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Maintenance of stable heterochromatin domains by dynamic HP1 binding. |
2003 |
Science |
pmid:12560555
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Boutillier AL et al. |
Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. |
2003 |
J. Neurochem. |
pmid:12562525
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The effect of oxidative stress on histone acetylation and IL-8 release. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12565901
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Kao HH et al. |
Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. |
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J. Biomed. Sci. |
pmid:12566991
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Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. |
2003 |
Plant J. |
pmid:12581304
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Jang IC et al. |
Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. |
2003 |
Plant J. |
pmid:12581311
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Kim Y et al. |
Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. |
2003 |
Oncogene |
pmid:12584561
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Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. |
2002 |
Endocrine |
pmid:12588052
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Mishra N et al. |
Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. |
2003 |
J. Clin. Invest. |
pmid:12588892
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Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. |
2003 |
Mol. Cancer Ther. |
pmid:12589032
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Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. |
2003 |
J. Med. Chem. |
pmid:12593661
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Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. |
2003 |
Int. J. Cancer |
pmid:12594812
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Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12604329
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Sakai N et al. |
Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. |
2003 |
J. Biol. Chem. |
pmid:12609987
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Kim SY et al. |
Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. |
2003 |
J. Virol. |
pmid:12610114
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Wang S and Zhu J |
Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. |
2003 |
J. Biol. Chem. |
pmid:12611896
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Shaker S et al. |
Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. |
2003 |
Leuk. Res. |
pmid:12620295
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Sawa H et al. |
Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. |
2002 |
Brain Tumor Pathol |
pmid:12622137
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Camarero N et al. |
Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. |
2003 |
Nucleic Acids Res. |
pmid:12626711
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Huang Y et al. |
Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. |
2003 |
Int. J. Cancer |
pmid:12640681
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Shi W et al. |
Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. |
2003 |
Biol. Reprod. |
pmid:12646489
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Murumägi A et al. |
Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. |
2003 |
J. Biol. Chem. |
pmid:12651856
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Chandler SP et al. |
Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. |
2003 |
BMC Mol. Biol. |
pmid:12659659
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Kao GD et al. |
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. |
2003 |
J. Cell Biol. |
pmid:12668657
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The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. |
2003 |
J. Biol. Chem. |
pmid:12676952
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Detich N et al. |
The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. |
2003 |
J. Biol. Chem. |
pmid:12676953
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