| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Conjunctival Neoplasms | D003230 | 3 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Ganglioneuroma | D005729 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Lupus Vulgaris | D008177 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bhargavan B et al. | Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. | 2013 | Epigenetics | pmid:23386123 |
| Eriksson I et al. | The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. | 2013 | Exp. Cell Res. | pmid:23063877 |
| Wang Y et al. | Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. | 2013 | J. Biol. Chem. | pmid:23525112 |
| Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
| Seo J et al. | Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity. | 2013 | FEBS J. | pmid:24200051 |
| Ning SF et al. | Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2013 | Zygote | pmid:22355002 |
| Miyatake Y et al. | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. | 2013 | Am. J. Pathol. | pmid:23474084 |
| Hansberg-Pastor V et al. | The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. | 2013 | Steroids | pmid:23474171 |
| Webster SJ et al. | Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes. | 2013 | J. Biol. Chem. | pmid:23297421 |
| Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
| Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
| Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
| Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
| Mehdi O et al. | HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). | 2012 Mar-Apr | Pancreatology | pmid:22487525 |
| Kim YS et al. | Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22634317 |
| Reddy P | Editorial: HDAC inhibition begets more MDSCs. | 2012 | J. Leukoc. Biol. | pmid:22547132 |
| Srirattana K et al. | Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22578161 |
| Truong M et al. | Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence. | 2012 | Br. J. Cancer | pmid:22596233 |
| Hsu DW et al. | Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. | 2012 | Nucleic Acids Res. | pmid:22600736 |
| Icardi L et al. | Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2. | 2012 | FASEB J. | pmid:21957129 |
| Yang Q et al. | Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23043075 |
| Balsas P et al. | Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. | 2012 | Leuk. Res. | pmid:21978467 |
| Fan H et al. | Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. | 2012 | Epigenetics | pmid:23092945 |
| Hoque MA et al. | Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23021104 |
| Börner C et al. | Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. | 2012 | Neuroimmunomodulation | pmid:22262103 |
| Francisco R et al. | Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | 2012 | Cancer Lett. | pmid:22186300 |
| Wang HF et al. | Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice. | 2012 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:22992439 |
| Ma J et al. | Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. | 2012 | Int. J. Mol. Med. | pmid:22992863 |
| Shi YL et al. | Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. | 2012 | J. Dermatol. Sci. | pmid:22999682 |
| Zhang CZ et al. | Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma. | 2012 | Cell Cycle | pmid:22214764 |
| Zhai FX et al. | RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22179198 |
| Sancho-Pelluz J and Paquet-Durand F | HDAC inhibition prevents Rd1 mouse photoreceptor degeneration. | 2012 | Adv. Exp. Med. Biol. | pmid:22183322 |
| Chen H et al. | LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. | 2012 | Cancer Lett. | pmid:22743615 |
| Chuma M et al. | Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer. | 2012 | Biol. Pharm. Bull. | pmid:22466564 |
| Li J et al. | Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. | 2012 | Nat. Med. | pmid:22466704 |
| Majumdar G et al. | Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. | 2012 | BMC Genomics | pmid:23249388 |
| Sangalli JR et al. | Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle. | 2012 | Cell Reprogram | pmid:22468998 |
| Zhang S et al. | [Effect of trichostatin A and paclitaxel on the growth and apoptosis of lung adenocarcinoma cell lines]. | 2012 | Zhonghua Zhong Liu Za Zhi | pmid:22967465 |
| Yamamura N and Kishimoto T | Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma. | 2012 | Exp. Mol. Pathol. | pmid:22472323 |
| Zhang HN et al. | Endogenous glucocorticoids inhibit myocardial inflammation induced by lipopolysaccharide: involvement of regulation of histone deacetylation. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22472906 |
| Xiong H et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. | 2012 | Mol. Carcinog. | pmid:21520296 |
| Zhu K et al. | Expression characterization and the promoter activity analysis of zebrafish hdac4. | 2012 | Fish Physiol. Biochem. | pmid:21773810 |
| Chan JN et al. | Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. | 2012 | Mol. Cell Proteomics | pmid:22357554 |
| Rehni AK et al. | Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome. | 2012 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:22362134 |
| Ikehata M et al. | Different involvement of DNA methylation and histone deacetylation in the expression of solute-carrier transporters in 4 colon cancer cell lines. | 2012 | Biol. Pharm. Bull. | pmid:22382314 |
| Andrews KT et al. | Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. | 2012 | PLoS ONE | pmid:22384084 |
| Zhu S et al. | TSA-induced JMJD2B downregulation is associated with cyclin B1-dependent survivin degradation and apoptosis in LNCap cells. | 2012 | J. Cell. Biochem. | pmid:22388778 |
| Usui T et al. | HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22389387 |
| Jee BC et al. | Effect of trichostatin A on fertilization and embryo development during extended culture of mouse oocyte. | 2012 | Zygote | pmid:21269543 |
| Gupta K et al. | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | 2012 | PLoS ONE | pmid:23285096 |