| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Conjunctival Neoplasms | D003230 | 3 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Ganglioneuroma | D005729 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Lupus Vulgaris | D008177 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schuhmann NK et al. | Gene transfer into human cord blood-derived CD34(+) cells by adeno-associated viral vectors. | 2010 | Exp. Hematol. | pmid:20447441 |
| Zhang D et al. | [Effects of trichostatin A on human lung cancer cell strains A549]. | 2010 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:20450546 |
| Ju ZH et al. | [Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines]. | 2010 | Zhonghua Wai Ke Za Zhi | pmid:20450613 |
| Lu L et al. | Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. | 2010 | J. Immunol. | pmid:20304828 |
| Hizume K et al. | Nano-scale analyses of the chromatin decompaction induced by histone acetylation. | 2010 | Arch. Histol. Cytol. | pmid:22572182 |
| Tokési N et al. | TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. | 2010 | J. Biol. Chem. | pmid:20308065 |
| Tian F et al. | Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons. | 2010 | Ann. N. Y. Acad. Sci. | pmid:20633124 |
| Rössler R et al. | Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons. | 2010 | Neuroscience | pmid:20643196 |
| Rahman R et al. | Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high-grade childhood brain tumor cells. | 2010 | Mol. Cancer Ther. | pmid:20643785 |
| Tong JH et al. | Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. | 2010 | BMC Cancer | pmid:20525238 |
| Han DS et al. | Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways. | 2010 | J. Cell. Biochem. | pmid:20568119 |
| Trtkova K et al. | Binding of AR to SMRT/N-CoR complex and its co-operation with PSA promoter in prostate cancer cells treated with natural histone deacetylase inhibitor NaB. | 2010 | Neoplasma | pmid:20568894 |
| Legartova S et al. | Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors. | 2010 | Neoplasma | pmid:20568903 |
| Kim J et al. | PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells. | 2010 | Mol. Cancer Ther. | pmid:20571067 |
| Obier N and Müller AM | Chromatin flow cytometry identifies changes in epigenetic cell states. | 2010 | Cells Tissues Organs (Print) | pmid:19776550 |
| Fan J et al. | Expression and function of CD9 in melanoma cells. | 2010 | Mol. Carcinog. | pmid:19777564 |
| Xue K et al. | Synchronous behaviors of CBP and acetylations of lysine 18 and lysine 23 on histone H3 during porcine oocyte first meiotic division. | 2010 | Mol. Reprod. Dev. | pmid:20575085 |
| Alamdari N et al. | Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20538901 |
| Li J et al. | Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. | 2010 | Autophagy | pmid:20543569 |
| Vamadevan AS et al. | Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. | 2010 | Innate Immun | pmid:19710105 |
| Kaichi S et al. | Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. | 2010 | Cardiovasc. Res. | pmid:20547733 |
| Her S et al. | Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. | 2010 | J. Mol. Neurosci. | pmid:19728174 |
| Suh HS et al. | Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. | 2010 | J Neuroimmune Pharmacol | pmid:20157787 |
| Crosson CE et al. | Inhibition of histone deacetylase protects the retina from ischemic injury. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20164449 |
| Jang ER et al. | ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response. | 2010 | Exp. Mol. Med. | pmid:20164679 |
| Desai D et al. | SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20167479 |
| Ishimaru N et al. | Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20188708 |
| Popova AP et al. | Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20190033 |
| Calonge TM et al. | Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1. | 2010 | Genetics | pmid:20194963 |
| Fakhry H et al. | Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells. | 2010 | Hum. Pathol. | pmid:20178884 |
| Wood JP et al. | A comparison of differentiation protocols for RGC-5 cells. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20181845 |
| Das ZC et al. | Lyophilized somatic cells direct embryonic development after whole cell intracytoplasmic injection into pig oocytes. | 2010 | Cryobiology | pmid:20691649 |
| Mercer TR et al. | Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. | 2010 | BMC Neurosci | pmid:20137068 |
| Heier CR et al. | Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice. | 2010 | Hum. Mol. Genet. | pmid:20693262 |
| Hodges SJ et al. | The effect of epigenetic therapy on congenital neurogenic bladders--a pilot study. | 2010 | Urology | pmid:20138341 |
| Bradner JE et al. | Chemical phylogenetics of histone deacetylases. | 2010 | Nat. Chem. Biol. | pmid:20139990 |
| Gay S et al. | Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions. | 2010 | EMBO Rep. | pmid:20671737 |
| Okada T et al. | TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer. | 2010 | Genes Chromosomes Cancer | pmid:20140954 |
| Shahabi S et al. | Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. | 2010 | Gynecol. Oncol. | pmid:20674962 |
| Wessels I et al. | Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis. | 2010 | Immunology | pmid:20141541 |
| Zhang C et al. | Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. | 2010 | J. Hepatol. | pmid:20675009 |
| Choi YS et al. | Differentiation of human adipose-derived stem cells into beating cardiomyocytes. | 2010 | J. Cell. Mol. Med. | pmid:20070436 |
| Lee KJ et al. | Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. | 2010 | Biochim. Biophys. Acta | pmid:20080132 |
| Grabiec AM et al. | Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. | 2010 | J. Immunol. | pmid:20100935 |
| Chatterjee A et al. | An efficient synthesis of (+/-)-trichostatic Acid and analogues: a new route to (+/-)-trichostatin A. | 2010 | Org. Lett. | pmid:20104892 |
| Kicic A et al. | Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20110557 |
| Su Y et al. | Human RecQL4 helicase plays critical roles in prostate carcinogenesis. | 2010 | Cancer Res. | pmid:21045146 |
| Taura A et al. | Histone deacetylase inhibition enhances adenoviral vector transduction in inner ear tissue. | 2010 | Neuroscience | pmid:20060033 |
| Chou JL et al. | Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. | 2010 | Lab. Invest. | pmid:20065949 |
| Giles KE et al. | Chromatin boundaries, insulators, and long-range interactions in the nucleus. | 2010 | Cold Spring Harb. Symp. Quant. Biol. | pmid:21047907 |
| Chang J et al. | Hepatopoietin Cn suppresses apoptosis of human hepatocellular carcinoma cells by up-regulating myeloid cell leukemia-1. | 2010 | World J. Gastroenterol. | pmid:20066738 |
| Huber K et al. | Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins). | 2010 | J. Med. Chem. | pmid:20030343 |
| Kroening S et al. | Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20032117 |
| Bracha AL et al. | Carbon metabolism-mediated myogenic differentiation. | 2010 | Nat. Chem. Biol. | pmid:20081855 |
| Pan L et al. | Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. | 2010 | FEBS J. | pmid:20089040 |
| Bayles R et al. | Histone modifications regulate the norepinephrine transporter gene. | 2010 | Cell Cycle | pmid:21088495 |
| Wang J et al. | Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20089874 |
| Hutt DM et al. | Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. | 2010 | Nat. Chem. Biol. | pmid:19966789 |
| Li Y et al. | Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. | 2010 | Mol. Cancer | pmid:20946668 |
| Gupta PK et al. | Inhibitors selective for HDAC6 in enzymes and cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20947351 |
| Meng CF et al. | Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells. | 2010 | Cancer Invest. | pmid:19857042 |
| Sayan BS et al. | Induction of TAp63 by histone deacetylase inhibitors. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20043870 |
| Shiau RJ et al. | Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. | 2010 | Eur J Nutr | pmid:19639378 |
| Reichrath S et al. | Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206691 |
| Milagre I et al. | Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. | 2010 | J. Alzheimers Dis. | pmid:20930312 |
| Bertrand P | Inside HDAC with HDAC inhibitors. | 2010 | Eur J Med Chem | pmid:20223566 |
| Gao A et al. | Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression. | 2010 | Toxicol. Lett. | pmid:20230882 |
| Majid S et al. | Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer. | 2010 | Cancer Res. | pmid:20332239 |
| Khobta A et al. | Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. | 2010 | Nucleic Acids Res. | pmid:20338881 |
| Kim SH et al. | Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein. | 2010 | Breast Cancer Res. | pmid:20388208 |
| Kongruttanachok N et al. | Replication independent DNA double-strand break retention may prevent genomic instability. | 2010 | Mol. Cancer | pmid:20356374 |
| Terracciano S et al. | Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222. | 2010 | Bioorg. Med. Chem. | pmid:20381359 |
| Zhang LX et al. | Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20382965 |
| Pan L et al. | HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1. | 2010 | Cell. Mol. Immunol. | pmid:20383178 |
| Kim HB et al. | Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. | 2010 | Mol. Cell. Biol. | pmid:20385772 |
| MacTavish H et al. | Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. | 2010 | PLoS ONE | pmid:21283510 |
| Varma A and Kwon-Chung KJ | Heteroresistance of Cryptococcus gattii to fluconazole. | 2010 | Antimicrob. Agents Chemother. | pmid:20385871 |
| Yang H et al. | Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20404016 |
| Wang G et al. | The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. | 2010 | Regen Med | pmid:20210581 |
| Sponziello M et al. | Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. | 2010 | J. Endocrinol. Invest. | pmid:19794300 |
| Himaki T et al. | Effects of trichostatin A on in vitro development and transgene function in somatic cell nuclear transfer embryos derived from transgenic Clawn miniature pig cells. | 2010 | Anim. Sci. J. | pmid:20887307 |
| Wu P et al. | Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells. | 2010 | Cell Death Differ. | pmid:19798105 |
| Peidis P et al. | HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2. | 2010 | Aging (Albany NY) | pmid:21076179 |
| Di Renzo F et al. | VPA-related axial skeletal defects and apoptosis: a proposed event cascade. | 2010 | Reprod. Toxicol. | pmid:19850124 |
| Patil V et al. | Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group. | 2010 | Bioorg. Med. Chem. | pmid:19914074 |
| Choi JH et al. | TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19914212 |
| Dong G et al. | Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19889954 |
| Bhuiyan MM et al. | Production of Sei whale (Balaenoptera borealis) cloned embryos by inter- and intra-species somatic cell nuclear transfer. | 2010 | J. Reprod. Dev. | pmid:19893277 |
| Ellis JK et al. | Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes. | 2010 | J. Proteome Res. | pmid:19894772 |
| Wang N and Tilly JL | Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads. | 2010 | Cell Cycle | pmid:20009537 |
| Zhao H et al. | New biomarkers probing depth of cell senescence assessed by laser scanning cytometry. | 2010 | Cytometry A | pmid:20939035 |
| Wang L et al. | Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. | 2010 | Neuropsychopharmacology | pmid:20010550 |
| Lee CS et al. | Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines. | 2010 | Mol. Cell. Biochem. | pmid:20020183 |
| Estiu G et al. | On the inhibition of histone deacetylase 8. | 2010 | Bioorg. Med. Chem. | pmid:20472442 |
| Kobori A et al. | Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines. | 2010 | World J. Gastroenterol. | pmid:20480520 |
| Kiyokawa S et al. | New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group. | 2010 | Bioorg. Med. Chem. | pmid:20452226 |
| Barua S and Rege K | The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. | 2010 | Biomaterials | pmid:20452664 |
| Marshall H et al. | Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice. | 2010 | BMC Mol. Biol. | pmid:20429939 |
| Zhao TC et al. | gp-91 mediates histone deacetylase inhibition-induced cardioprotection. | 2010 | Biochim. Biophys. Acta | pmid:20433879 |
| Jeon HW and Lee YM | Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression. | 2010 | Mol. Cancer Ther. | pmid:20442303 |