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Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. |
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Eukaryotic Cell |
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Cancer Cell |
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Cell biology: Tubulin acetylation and cell motility. |
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Nature |
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Science |
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Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. |
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Oncogene |
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The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. |
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Cancer Res. |
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Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. |
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Mol. Cell. Biol. |
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Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. |
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Clin. Cancer Res. |
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Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. |
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Cancer Res. |
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A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. |
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Nucleic Acids Res. |
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Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. |
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Carcinogenesis |
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Acetylated sp3 is a transcriptional activator. |
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The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. |
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EMBO J. |
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Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. |
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Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. |
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Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. |
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Cancer Res. |
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Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. |
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Oncogene |
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Changes in histone acetylation during mouse oocyte meiosis. |
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Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. |
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Nucleic Acids Res. |
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Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. |
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Biochem. Biophys. Res. Commun. |
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The SV40 T antigen modulates CBP histone acetyltransferase activity. |
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Nucleic Acids Res. |
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Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. |
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Nucleic Acids Res. |
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A multistep mechanism for the activation of rearrangement in the immune system. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. |
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J. Hematother. Stem Cell Res. |
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The histone code regulating expression of the imprinted mouse Igf2r gene. |
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Endocrinology |
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Identification of novel isoform-selective inhibitors within class I histone deacetylases. |
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J. Pharmacol. Exp. Ther. |
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EMBO J. |
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Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. |
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Biol. Reprod. |
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Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. |
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Bioorg. Med. Chem. Lett. |
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Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. |
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Cancer Res. |
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Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. |
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Gut |
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Generation of hepatocyte-like cells from human embryonic stem cells. |
2003 |
Cell Transplant |
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Activation of terminal B cell differentiation by inhibition of histone deacetylation. |
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Mol. Immunol. |
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