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Carcinogenesis |
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Dev. Cell |
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Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. |
2004 |
Chest |
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2004 |
Virus Genes |
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2004 |
Bioorg. Med. Chem. Lett. |
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A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. |
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Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy. |
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Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. |
2004 |
Free Radic. Biol. Med. |
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SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. |
2004 |
Biochem. Biophys. Res. Commun. |
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Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. |
2004 |
Oncology |
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Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A. |
2004 |
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2004 |
Cancer Biol. Ther. |
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Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. |
2004 |
Circ. Res. |
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Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. |
2004 |
Cancer Cell |
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Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. |
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The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. |
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Eukaryotic Cell |
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Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. |
2004 |
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Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. |
2004 |
Oncogene |
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Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. |
2004 |
Biochim. Biophys. Acta |
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Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. |
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Leuk. Lymphoma |
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A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. |
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Cancer Res. |
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2004 |
Apoptosis |
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Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. |
2004 |
Apoptosis |
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Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. |
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Exp. Cell Res. |
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Cell Res. |
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Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors. |
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Nucleic Acids Res. |
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Mol. Cell. Biol. |
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Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. |
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Int. J. Radiat. Oncol. Biol. Phys. |
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Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. |
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J. Biol. Chem. |
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Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. |
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Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. |
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J. Virol. |
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Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins. |
2004 |
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The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. |
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Blood Cells Mol. Dis. |
pmid:12737942
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