| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Carcinoma, Pancreatic Ductal | D021441 | 6 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| He D et al. | Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma. | 2012 | Eur. J. Cancer Prev. | pmid:22273848 |
| Hosoya T et al. | Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. | 2012 | J. Nat. Prod. | pmid:22276693 |
| de Souza CF et al. | Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. | 2012 | PLoS ONE | pmid:22984562 |
| Yao J et al. | ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism. | 2012 | Life Sci. | pmid:22781708 |
| Cheng DD et al. | Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799338 |
| Nunes MJ et al. | Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway. | 2012 | J. Lipid Res. | pmid:22693257 |
| Karolczak-Bayatti M et al. | Expression of the GTP-binding protein Gαs in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A. | 2012 | Reprod Sci | pmid:22875848 |
| Mostovich LA et al. | Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. | 2011 Sep-Oct | Cell Adh Migr | pmid:21975548 |
| Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
| Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
| Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
| Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
| Aoyama K et al. | Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. | 2011 | Exp. Cell Res. | pmid:22001646 |
| Jeon HG et al. | Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. | 2011 | J. Urol. | pmid:21944112 |
| Meester-Smoor MA et al. | The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. | 2011 | PLoS ONE | pmid:21949683 |
| Zhang L et al. | ABA treatment of germinating maize seeds induces VP1 gene expression and selective promoter-associated histone acetylation. | 2011 | Physiol Plant | pmid:21679193 |
| Lin S et al. | HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells. | 2011 | Curr. HIV Res. | pmid:21631428 |
| Jugová A et al. | Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. | 2011 | Cell Biol. Int. | pmid:21635225 |
| Wong CY et al. | Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. | 2011 | J. Biol. Chem. | pmid:21636851 |
| Hayashi-Takanaka Y et al. | Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. | 2011 | Nucleic Acids Res. | pmid:21576221 |
| Bouquet F et al. | A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. | 2011 | J. Cell. Sci. | pmid:21576354 |
| Hawk JD et al. | Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. | 2011 | Learn. Mem. | pmid:21576516 |
| Cui XS et al. | Trichostatin A modulates apoptotic-related gene expression and improves embryo viability in cloned bovine embryos. | 2011 | Cell Reprogram | pmid:21473694 |
| Sun JY et al. | Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia. | 2011 | Clin Lymphoma Myeloma Leuk | pmid:21454220 |
| Kong QR et al. | [TSA improve transgenic porcine cloned embryo development and transgene expression]. | 2011 | Yi Chuan | pmid:22049689 |
| Min XJ et al. | Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21454376 |
| Belakavadi M et al. | Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. | 2011 | Mol. Cell. Endocrinol. | pmid:21458529 |
| Zelko IN et al. | Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21493784 |
| da Costa Prando E et al. | Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. | 2011 | Epigenetics | pmid:22139571 |
| Kretzner L et al. | Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. | 2011 | Cancer Res. | pmid:21502403 |
| Poplineau M et al. | Raman microspectroscopy detects epigenetic modifications in living Jurkat leukemic cells. | 2011 | Epigenomics | pmid:22126296 |
| Qiu GH et al. | Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. | 2011 | Mol. Ther. | pmid:21540836 |
| Wang QS et al. | [Silence mechanism of WT1 gene in leukemic cell line U937]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22040952 |
| Biermann J et al. | Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells. | 2011 | Mol. Vis. | pmid:21311741 |
| Jackson K et al. | Epigenetic silencing of somatostatin in gastric cancer. | 2011 | Dig. Dis. Sci. | pmid:20927589 |
| Sahu GK and Cloyd MW | Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors. | 2011 | Virol. J. | pmid:21838863 |
| Yu D et al. | Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21840716 |
| Atanackovic D et al. | Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. | 2011 | Am. J. Hematol. | pmid:21898529 |
| Paterson S et al. | Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. | 2011 | Drug Metab. Dispos. | pmid:20870783 |
| Wang JP et al. | Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. | 2011 | PLoS ONE | pmid:21901157 |
| Nakaya Y et al. | Epigenetic regulation on the 5'-proximal CpG island of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B. | 2011 | Microbes Infect. | pmid:20951222 |
| Robers MB et al. | Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. | 2011 | Mol Biosyst | pmid:20931131 |
| Hsu YF et al. | MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. | 2011 | Biochim. Biophys. Acta | pmid:21911040 |
| Puppin C et al. | Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. | 2011 | Oncol. Rep. | pmid:21152868 |
| Tsai PF et al. | Interplay between PKCδ and Sp1 on histone deacetylase inhibitor-mediated Epstein-Barr virus reactivation. | 2011 | J. Virol. | pmid:21159880 |
| Nandakumar V et al. | (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. | 2011 | Carcinogenesis | pmid:21209038 |
| Kang H and Roh S | Extended exposure to trichostatin A after activation alters the expression of genes important for early development in nuclear transfer murine embryos. | 2011 | J. Vet. Med. Sci. | pmid:21187677 |
| Mitmaker EJ et al. | Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors. | 2011 | Surgery | pmid:21193210 |
| Liao M et al. | Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription. | 2011 | J. Biol. Chem. | pmid:21193408 |
| Host L et al. | Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition. | 2011 | J. Psychopharmacol. (Oxford) | pmid:19939859 |