| MeSH term | MeSH ID | Detail |
|---|---|---|
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Lymphoma, Follicular | D008224 | 3 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Poplineau M et al. | Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells. | 2013 | Cell Prolif. | pmid:23510467 |
| Liu J et al. | Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. | 2013 | Sci Rep | pmid:23378917 |
| Liu YQ et al. | Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. | 2013 | Genet. Mol. Res. | pmid:24089095 |
| Florea AM | DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals. | 2013 | Biomed Res Int | pmid:24093099 |
| Jung AR et al. | Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment. | 2013 | Anticancer Res. | pmid:23482750 |
| Kim TW et al. | Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. | 2013 | BMC Cancer | pmid:24160266 |
| Di Micco S et al. | Structural basis for the design and synthesis of selective HDAC inhibitors. | 2013 | Bioorg. Med. Chem. | pmid:23693069 |
| Xia X et al. | Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. | 2013 | Transplantation | pmid:23694951 |
| Nunes MJ et al. | Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. | 2013 | PLoS ONE | pmid:23326422 |
| Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
| Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
| Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
| Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
| Mehdi O et al. | HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). | 2012 Mar-Apr | Pancreatology | pmid:22487525 |
| Kadaja-Saarepuu L et al. | Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. | 2012 | Int. J. Oncol. | pmid:21947346 |
| Ekici M et al. | Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: major regulatory role of REST and Sp1. | 2012 | J. Cell. Biochem. | pmid:21948504 |
| Rosborough BR et al. | Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. | 2012 | J. Leukoc. Biol. | pmid:22028329 |
| Tsuboi H et al. | Epigenetic memory of DNAi associated with cytosine methylation and histone modification in fern. | 2012 | Plant Signal Behav | pmid:22990449 |
| Maroni P et al. | Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23085045 |
| Banerjee A et al. | Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22298527 |
| Kerr JB et al. | The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. | 2012 | Reproduction | pmid:22301887 |
| Li H et al. | Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. | 2012 | Diabetes | pmid:22338096 |
| Duncan HF et al. | Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. | 2012 | J Endod | pmid:22341071 |
| Kohda T et al. | Gene expression profile normalization in cloned mice by trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22257163 |
| Drzewiecka H and Jagodzinski PP | Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22257695 |
| Becker JR et al. | In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. | 2012 | Cardiovasc. Res. | pmid:22198505 |
| Hsu YF et al. | Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22155142 |
| Bebenek IG et al. | CYP2S1 is negatively regulated by corticosteroids in human cell lines. | 2012 | Toxicol. Lett. | pmid:22155357 |
| Sakuma Y et al. | WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. | 2012 | Lab. Invest. | pmid:22157722 |
| Schor IE et al. | Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. | 2012 | PLoS ONE | pmid:23152763 |
| Chang J et al. | Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. | 2012 | Br. J. Cancer | pmid:22158273 |
| Calfa G et al. | HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. | 2012 | Hippocampus | pmid:22161912 |
| Brose RD et al. | Activation of the stress proteome as a mechanism for small molecule therapeutics. | 2012 | Hum. Mol. Genet. | pmid:22752410 |
| Jasek E et al. | Effect of histone deacetylase inhibitors trichostatin A and valproic acid on etoposide-induced apoptosis in leukemia cells. | 2012 | Anticancer Res. | pmid:22753739 |
| Gan L et al. | Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. | 2012 | PLoS ONE | pmid:22761896 |
| Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
| Rossi LE et al. | Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. | 2012 | J. Leukoc. Biol. | pmid:22124136 |
| Landreville S et al. | Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. | 2012 | Clin. Cancer Res. | pmid:22038994 |
| Zhang YW et al. | Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. | 2012 | PLoS ONE | pmid:22701735 |
| Mitchell MD et al. | Epigenetic regulation of cytokine production in human amnion and villous placenta. | 2012 | Mediators Inflamm. | pmid:22665947 |
| Buurman R et al. | Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. | 2012 | Gastroenterology | pmid:22641068 |
| Orlova DY et al. | Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. | 2012 | J. Cell. Biochem. | pmid:22644811 |
| Glait-Santar C et al. | Expression pattern of SVEP1 alternatively-spliced forms. | 2012 | Gene | pmid:22659106 |
| Park J et al. | ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22580278 |
| Yin Z et al. | Position effect variegation and epigenetic modification of a transgene in a pig model. | 2012 | Genet. Mol. Res. | pmid:22370938 |
| Zhu L et al. | Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. | 2012 | Pediatr. Pulmonol. | pmid:21905265 |
| Pufahl L et al. | Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. | 2012 | J. Cell. Mol. Med. | pmid:21883892 |
| Li L et al. | Regulation of histone acetylation by NDRG2 in glioma cells. | 2012 | J. Neurooncol. | pmid:21912936 |
| He M and Guo Q | [Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22561570 |
| Catalano MG et al. | Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22563106 |