| MeSH term | MeSH ID | Detail |
|---|---|---|
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Lymphoma, Follicular | D008224 | 3 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Srirattana K et al. | Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22578161 |
| Wang HF et al. | Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice. | 2012 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:22992439 |
| Ma J et al. | Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. | 2012 | Int. J. Mol. Med. | pmid:22992863 |
| Zhai FX et al. | RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22179198 |
| Yamamura N and Kishimoto T | Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma. | 2012 | Exp. Mol. Pathol. | pmid:22472323 |
| Andrews KT et al. | Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. | 2012 | PLoS ONE | pmid:22384084 |
| Gupta K et al. | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | 2012 | PLoS ONE | pmid:23285096 |
| Mostovich LA et al. | Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. | 2011 Sep-Oct | Cell Adh Migr | pmid:21975548 |
| Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
| Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
| Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
| Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
| Hirata H et al. | Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. | 2011 | Int. J. Cancer | pmid:20549706 |
| Ohtani K et al. | Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. | 2011 | Circ. Res. | pmid:21980126 |
| Hagiwara H et al. | Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22019851 |
| Jafari S et al. | Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos. | 2011 | J. Assist. Reprod. Genet. | pmid:22020531 |
| Tseng AS et al. | HDAC activity is required during Xenopus tail regeneration. | 2011 | PLoS ONE | pmid:22022609 |
| Kaichi S et al. | Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. | 2011 | J. Cell. Physiol. | pmid:20665673 |
| Shiratsuki S et al. | Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. | 2011 | Theriogenology | pmid:21144563 |
| Xia B et al. | Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. | 2011 | Toxicol. Lett. | pmid:21641978 |
| Seo SK et al. | Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. | 2011 | J Thorac Oncol | pmid:21642861 |
| Acun T et al. | SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. | 2011 | BMC Cancer | pmid:21645397 |
| Hou J et al. | Structure-based optimization of click-based histone deacetylase inhibitors. | 2011 | Eur J Med Chem | pmid:21621883 |
| Zhang J et al. | Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. | 2011 | Endocrinology | pmid:21406501 |
| Kawasaki H et al. | Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. | 2011 | PLoS ONE | pmid:21407806 |
| Li Z et al. | Epigenetic inactivation of PCDH10 in human prostate cancer cell lines. | 2011 | Cell Biol. Int. | pmid:21314642 |
| Saiyed ZM et al. | HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). | 2011 | Neurochem. Int. | pmid:21315782 |
| Fang Y et al. | Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. | 2011 | Cancer Invest. | pmid:21345073 |
| Qian Y et al. | DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. | 2011 | J. Biol. Chem. | pmid:21317427 |
| Zhang F et al. | Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. | 2011 | PLoS ONE | pmid:21346816 |
| Miller L et al. | Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. | 2011 | Physiol. Behav. | pmid:21463644 |
| Law AY et al. | Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. | 2011 | J. Cell. Biochem. | pmid:21465530 |
| Blanquart C et al. | Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. | 2011 | Curr Cancer Drug Targets | pmid:21762083 |
| Pang M et al. | Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. | 2011 | J. Cell. Biochem. | pmid:21465537 |
| Wan Y et al. | Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. | 2011 | FEBS Lett. | pmid:21763693 |
| Kimura T et al. | Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. | 2011 | J Toxicol Sci | pmid:21467744 |
| Zhang CZ et al. | Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. | 2011 | Apoptosis | pmid:21468663 |
| Hu Y et al. | Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. | 2011 | PLoS ONE | pmid:21811564 |
| Chen YT et al. | Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. | 2011 | Spine | pmid:21343850 |
| Amoêdo ND et al. | Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. | 2011 | PLoS ONE | pmid:21789245 |
| Fu S et al. | Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. | 2011 | PLoS ONE | pmid:22132182 |
| Choi E et al. | Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21256006 |
| Mizuno S et al. | Inhibition of histone deacetylase causes emphysema. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21224215 |
| Hai T et al. | Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. | 2011 | Cell Reprogram | pmid:21241188 |
| Nakamura J et al. | Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. | 2011 | Am. J. Pathol. | pmid:21281785 |
| Puppin C et al. | In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription. | 2011 | Cell Oncol (Dordr) | pmid:21290209 |
| Vassiliev I et al. | Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A. | 2011 | Cell Reprogram | pmid:21548828 |
| Ververis K et al. | Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. | 2011 | Cell. Mol. Life Sci. | pmid:21584806 |
| Misaki K et al. | Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. | 2011 | Arthritis Res. Ther. | pmid:21592365 |
| Selinger CI et al. | Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. | 2011 | J Thorac Oncol | pmid:21597389 |