| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ailenberg M and Silverman M | Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604329 |
| Sakai N et al. | Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. | 2003 | J. Biol. Chem. | pmid:12609987 |
| Kim SY et al. | Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. | 2003 | J. Virol. | pmid:12610114 |
| Wang S and Zhu J | Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. | 2003 | J. Biol. Chem. | pmid:12611896 |
| Shaker S et al. | Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. | 2003 | Leuk. Res. | pmid:12620295 |
| McGhee L et al. | Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. | 2003 | J. Cell. Biochem. | pmid:12874834 |
| Li C et al. | Effect and comparison of sodium butyrate and trichostatin A on the proliferation/differentiation of K562. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:14526425 |
| Hejnar J et al. | Demethylation of host-cell DNA at the site of avian retrovirus integration. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14623319 |
| Adam E et al. | Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. | 2003 | Mol. Cell. Biol. | pmid:12917341 |
| Usenko T et al. | Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. | 2003 | Oncogene | pmid:14576829 |
| Vasudevan A et al. | Heterocyclic ketones as inhibitors of histone deacetylase. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592473 |
| Chung YL et al. | A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. | 2003 | Mol. Ther. | pmid:14599803 |
| Lu F et al. | Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. | 2003 | J. Virol. | pmid:14557628 |
| Siddiqui H et al. | Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. | 2003 | Mol. Cell. Biol. | pmid:14560017 |
| Marshall S et al. | Enhanced expression of uridine diphosphate-N-acetylglucosaminyl transferase (OGT) in a stable, tetracycline-inducible HeLa cell line using histone deacetylase inhibitors: kinetics of cytosolic OGT accumulation and nuclear translocation. | 2003 | Anal. Biochem. | pmid:12871726 |
| Yamada Y et al. | Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. | 2003 | Cancer Sci. | pmid:12824880 |
| Shi W et al. | Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. | 2003 | Biol. Reprod. | pmid:12646489 |
| Murumägi A et al. | Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. | 2003 | J. Biol. Chem. | pmid:12651856 |
| Kang J et al. | Nickel-induced histone hypoacetylation: the role of reactive oxygen species. | 2003 | Toxicol. Sci. | pmid:12773760 |
| Mihaylova VT et al. | Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. | 2003 | Mol. Cell. Biol. | pmid:12697826 |
| Kao GD et al. | Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. | 2003 | J. Cell Biol. | pmid:12668657 |
| Yasui W et al. | Histone acetylation and gastrointestinal carcinogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12724227 |
| Jedrusik MA and Schulze E | Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. | 2003 | Mol. Cell. Biol. | pmid:12724425 |
| Vos MD et al. | The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. | 2003 | J. Biol. Chem. | pmid:12676952 |
| Kao HH et al. | Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. | 2003 Jan-Feb | J. Biomed. Sci. | pmid:12566991 |
| Kagoshima M et al. | How signaling pathways interact with gene transcription. | 2003 Jan-Mar | Monaldi Arch Chest Dis | pmid:14533280 |
| Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |
| Flørenes VA et al. | Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. | 2004 | Melanoma Res. | pmid:15179185 |
| Ahn MR et al. | Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. | 2004 | Arch. Pharm. Res. | pmid:15180307 |
| Ramakrishnan G et al. | Histone acetyltransferases and deacetylase in Entamoeba histolytica. | 2004 | Mol. Biochem. Parasitol. | pmid:15555732 |
| Chang HC et al. | Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. | 2004 | Cell. Signal. | pmid:15093608 |
| Nishino N et al. | Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109626 |
| Marson CM et al. | Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109636 |
| Arapshian A et al. | Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. | 2004 | Mol. Cancer | pmid:15113415 |
| Ladd PD et al. | Identification of a genomic fragment that directs hematopoietic-specific expression of Rac2 and analysis of the DNA methylation profile of the gene locus. | 2004 | Gene | pmid:15474314 |
| Li H and Wu X | Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474507 |
| Spenger A et al. | Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. | 2004 | Protein Expr. Purif. | pmid:15477077 |
| Yee SB et al. | Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. | 2004 | Int. J. Oncol. | pmid:15492835 |
| Chen YX et al. | Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. | 2004 | World J. Gastroenterol. | pmid:15309711 |
| Heltweg B et al. | Subtype selective substrates for histone deacetylases. | 2004 | J. Med. Chem. | pmid:15456267 |
| Alikhani-Koopaei R et al. | Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. | 2004 | J. Clin. Invest. | pmid:15489962 |
| Jang ER et al. | The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen. | 2004 | Oncogene | pmid:14676837 |
| Thelen P et al. | Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. | 2004 | Int. J. Oncol. | pmid:14654937 |
| Kramps C et al. | E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. | 2004 | J. Biol. Chem. | pmid:14645238 |
| Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
| Schultz BE et al. | Kinetics and comparative reactivity of human class I and class IIb histone deacetylases. | 2004 | Biochemistry | pmid:15323567 |
| Tao D et al. | Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. | 2004 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:15346199 |
| Korkmaz CG et al. | Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants. | 2004 | J. Endocrinol. | pmid:15350180 |
| Sumer H et al. | Effects of scaffold/matrix alteration on centromeric function and gene expression. | 2004 | J. Biol. Chem. | pmid:15220334 |
| Lee YJ et al. | Mechanism of transcriptional repression by TEL/RUNX1 fusion protein. | 2004 | Mol. Cells | pmid:15179033 |