| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ekici M et al. | Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: major regulatory role of REST and Sp1. | 2012 | J. Cell. Biochem. | pmid:21948504 |
| Banerjee A et al. | Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22298527 |
| Hsu YF et al. | Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22155142 |
| Brose RD et al. | Activation of the stress proteome as a mechanism for small molecule therapeutics. | 2012 | Hum. Mol. Genet. | pmid:22752410 |
| Zhang YW et al. | Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. | 2012 | PLoS ONE | pmid:22701735 |
| Mitchell MD et al. | Epigenetic regulation of cytokine production in human amnion and villous placenta. | 2012 | Mediators Inflamm. | pmid:22665947 |
| Zhu L et al. | Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. | 2012 | Pediatr. Pulmonol. | pmid:21905265 |
| Mostovich LA et al. | Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. | 2011 Sep-Oct | Cell Adh Migr | pmid:21975548 |
| Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
| Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
| Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
| Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
| Meester-Smoor MA et al. | The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. | 2011 | PLoS ONE | pmid:21949683 |
| Halder SK et al. | Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. | 2011 | Neoplasia | pmid:22028617 |
| Hutt DM et al. | Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. | 2011 | ACS Med Chem Lett | pmid:21984958 |
| Wang JP et al. | Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression. | 2011 | Differentiation | pmid:21074928 |
| Oyer JA et al. | Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation. | 2011 | Mutat. Res. | pmid:21035468 |
| Pabba C et al. | Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21109435 |
| Vrzal R et al. | Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia? | 2011 | Toxicol. Lett. | pmid:21115105 |
| Poljakova J et al. | Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. | 2011 | Neuro Endocrinol. Lett. | pmid:22167207 |
| Williams PJ et al. | HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. | 2011 | Ann. N. Y. Acad. Sci. | pmid:22172035 |
| Hawk JD et al. | Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. | 2011 | Learn. Mem. | pmid:21576516 |
| Dong X et al. | Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. | 2011 | Endocr. Relat. Cancer | pmid:21367844 |
| Zhu QY et al. | C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. | 2011 | Cell Death Dis | pmid:21368888 |
| Hsu YF et al. | p53 in trichostatin A induced C6 glioma cell death. | 2011 | Biochim. Biophys. Acta | pmid:21376104 |
| Ryhänen T et al. | Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells. | 2011 | J. Biomed. Biotechnol. | pmid:20981255 |
| Briggs B et al. | Photosensitization by iodinated DNA minor groove binding ligands: Evaluation of DNA double-strand break induction and repair. | 2011 | J. Photochem. Photobiol. B, Biol. | pmid:21440453 |
| Seitz V et al. | Classical Hodgkin's lymphoma shows epigenetic features of abortive plasma cell differentiation. | 2011 | Haematologica | pmid:21393330 |
| Qiu GH et al. | Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. | 2011 | Mol. Ther. | pmid:21540836 |
| Kong Q et al. | Effect of trichostatin A and 5-Aza-2'-deoxycytidine on transgene reactivation and epigenetic modification in transgenic pig fibroblast cells. | 2011 | Mol. Cell. Biochem. | pmid:21541675 |
| Wang QS et al. | [Silence mechanism of WT1 gene in leukemic cell line U937]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22040952 |
| Park JW et al. | Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. | 2011 | J. Nat. Prod. | pmid:21504214 |
| Matoba S et al. | RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22065773 |
| Bolleyn J et al. | Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. | 2011 | Toxicol In Vitro | pmid:21513791 |
| Rajasingh J et al. | Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. | 2011 | PLoS ONE | pmid:21799893 |
| Ramsey MR et al. | Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. | 2011 | Cancer Res. | pmid:21527555 |
| Klawitter M et al. | Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. | 2011 | J Negat Results Biomed | pmid:21801383 |
| Tong Y et al. | PTTG1 attenuates drug-induced cellular senescence. | 2011 | PLoS ONE | pmid:21858218 |
| Robers MB et al. | Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. | 2011 | Mol Biosyst | pmid:20931131 |
| Hsu YF et al. | MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. | 2011 | Biochim. Biophys. Acta | pmid:21911040 |
| Crandall JE et al. | Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. | 2011 | J. Neurochem. | pmid:21895658 |
| Bogaard HJ et al. | Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:21297075 |
| Jafarpour F et al. | Somatic cell-induced hyperacetylation, but not hypomethylation, positively and reversibly affects the efficiency of in vitro cloned blastocyst production in cattle. | 2011 | Cell Reprogram | pmid:21919704 |
| Chen S et al. | [Effect of trichostatin alone and combination with imatinb on the proliferation and apoptosis of the K562R cells]. | 2011 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:21937807 |
| Zou CF et al. | Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. | 2011 | BMC Cancer | pmid:21244707 |
| Erb TM et al. | Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. | 2011 | Stem Cells Dev. | pmid:21204619 |
| Farinas B and Mas P | Functional implication of the MYB transcription factor RVE8/LCL5 in the circadian control of histone acetylation. | 2011 | Plant J. | pmid:21205033 |
| Host L et al. | Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition. | 2011 | J. Psychopharmacol. (Oxford) | pmid:19939859 |
| Muralidhar SA et al. | Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells. | 2011 | J. Biol. Chem. | pmid:21078662 |
| Chakravarty G et al. | Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. | 2011 | Cancer Biol. Ther. | pmid:21084857 |