| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gray SG et al. | Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. | 2000 | Int. J. Mol. Med. | pmid:10601571 |
| Chen WY and Townes TM | Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10618426 |
| Xiao H et al. | p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor. | 2000 | J. Biol. Chem. | pmid:10625687 |
| Avram D et al. | Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. | 2000 | J. Biol. Chem. | pmid:10744719 |
| Eickhoff B et al. | Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. | 2000 | Biol. Chem. | pmid:10746741 |
| Lee SK et al. | Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. | 2000 | J. Biol. Chem. | pmid:10777532 |
| Zhang HS et al. | Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. | 2000 | Cell | pmid:10778858 |
| Asoh S et al. | The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. | 2000 | J. Biol. Chem. | pmid:10970895 |
| Cong YS and Bacchetti S | Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. | 2000 | J. Biol. Chem. | pmid:10986277 |
| Wei LN et al. | Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. | 2000 | J. Biol. Chem. | pmid:11006275 |
| Badia E et al. | Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling. | 2000 | Cancer Res. | pmid:10945620 |
| Wharton W et al. | Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. | 2000 | J. Biol. Chem. | pmid:10945992 |
| Zhou Q et al. | Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. | 2000 | J. Biol. Chem. | pmid:10938272 |
| Xu RH et al. | Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction. | 2000 | Dev. Dyn. | pmid:10906781 |
| Gray SG et al. | IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. | 2000 | Cytokine | pmid:10880258 |
| DiRenzo J et al. | BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. | 2000 | Mol. Cell. Biol. | pmid:11003650 |
| Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
| Eickhoff B et al. | Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. | 2000 | Biol. Chem. | pmid:11154071 |
| Yang X et al. | Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. | 2000 | Cancer Res. | pmid:11156387 |
| Dressel U et al. | Promoter specific sensitivity to inhibition of histone deacetylases: implications for hormonal gene control, cellular differentiation and cancer. | 2000 Mar-Apr | Anticancer Res. | pmid:10810390 |
| Steinbac OC et al. | Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in Xenopus. | 2000 Sep-Oct | Biol. Chem. | pmid:11076034 |
| Jung M | Inhibitors of histone deacetylase as new anticancer agents. | 2001 | Curr. Med. Chem. | pmid:11562279 |
| Ashburner BP et al. | The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. | 2001 | Mol. Cell. Biol. | pmid:11564889 |
| Sachs LM et al. | Involvement of histone deacetylase at two distinct steps in gene regulation during intestinal development in Xenopus laevis. | 2001 | Dev. Dyn. | pmid:11668605 |
| Amann JM et al. | ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. | 2001 | Mol. Cell. Biol. | pmid:11533236 |
| Plant KE et al. | Intergenic transcription in the human beta-globin gene cluster. | 2001 | Mol. Cell. Biol. | pmid:11533239 |
| Chen Lf W et al. | Duration of nuclear NF-kappaB action regulated by reversible acetylation. | 2001 | Science | pmid:11533489 |
| Vinatzer U et al. | The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase. | 2001 | Br. J. Haematol. | pmid:11552981 |
| Sekimata M et al. | Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. | 2001 | J. Biol. Chem. | pmid:11553631 |
| Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
| Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
| Bovenzi V and Momparler RL | Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. | 2001 | Cancer Chemother. Pharmacol. | pmid:11488527 |
| Franco PJ et al. | The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. | 2001 | Mol. Endocrinol. | pmid:11463856 |
| Pujuguet P et al. | Trichostatin A inhibits beta-casein expression in mammary epithelial cells. | 2001 | J. Cell. Biochem. | pmid:11746508 |
| Matsusue K et al. | Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. | 2001 | DNA Cell Biol. | pmid:11749719 |
| Grande A et al. | A functionally active RARalpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines. | 2001 | Cell Death Differ. | pmid:11313705 |
| Wu Y et al. | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. | 2001 | Oncogene | pmid:11313951 |
| Greenberg VL et al. | Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells. | 2001 | Thyroid | pmid:11349829 |
| Lea MA et al. | Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. | 2001 | Int. J. Cancer | pmid:11351296 |
| Jordan A et al. | The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. | 2001 | EMBO J. | pmid:11285236 |
| Bachl J et al. | Increased transcription levels induce higher mutation rates in a hypermutating cell line. | 2001 | J. Immunol. | pmid:11290786 |
| Mishra N et al. | Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226290 |
| Ding BC et al. | Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. | 2001 | Biochem. Pharmacol. | pmid:11266651 |
| Arthur JL et al. | Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro. | 2001 | J. Virol. | pmid:11264377 |
| Meier JL | Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator. | 2001 | J. Virol. | pmid:11160656 |
| Kuusisto E et al. | Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162503 |
| Grandjean V et al. | Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain. | 2001 | FEBS Lett. | pmid:11163765 |
| Lizcano F et al. | Cell type-specific roles of histone deacetylase in TR ligand-independent transcriptional repression. | 2001 | Mol. Cell. Endocrinol. | pmid:11165035 |
| Nervi C et al. | Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. | 2001 | Cancer Res. | pmid:11245412 |
| Zhu WG et al. | DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | 2001 | Cancer Res. | pmid:11245429 |