| MeSH term | MeSH ID | Detail |
|---|---|---|
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sanaei M et al. | Genistein and Trichostatin A Induction of Estrogen Receptor Alpha Gene Expression, Apoptosis and Cell Growth Inhibition in Hepatocellular Carcinoma HepG 2 Cells | 2017 | Asian Pac. J. Cancer Prev. | pmid:29286617 |
| Zohre S et al. | Trichostatin A-induced apoptosis is mediated by Kruppel-like factor 4 in ovarian and lung cancer. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25169491 |
| Zhang QC et al. | Histone deacetylase inhibitor trichostatin A enhances anti-tumor effects of docetaxel or erlotinib in A549 cell line. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22994780 |
| Bao Y et al. | Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. | 2009 | Atherosclerosis | pmid:18930459 |
| Li J et al. | Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. | 2010 | Autophagy | pmid:20543569 |
| Liu YL et al. | Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma. | 2010 | Autophagy | pmid:20962572 |
| Knobloch J et al. | Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:23981542 |
| Miyagawa K et al. | Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice. | 2012 | Behav. Brain Res. | pmid:22963996 |
| Moldrich RX et al. | Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. | 2013 | Behav. Brain Res. | pmid:24103642 |
| Lattal KM et al. | Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. | 2007 | Behav. Neurosci. | pmid:17907845 |
| Seo J et al. | Differential expression of stromal cell-derived factor 1 in human brain microvascular endothelial cells and pericytes involves histone modifications. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19289100 |
| Aquea F et al. | Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27993678 |
| Cho B et al. | Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12849980 |
| Wu P et al. | Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16051188 |
| Sowa Y et al. | Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9405248 |
| Rao J et al. | Trichostatin-A induces differential changes in histone protein dynamics and expression in HeLa cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17869223 |
| Ma AN et al. | Histone deacetylation directs DNA methylation in survivin gene silencing. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21130077 |
| Liu J and Li Y | Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26436206 |
| Koh SH et al. | Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15752760 |
| Shi H et al. | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23201405 |