| MeSH term | MeSH ID | Detail |
|---|---|---|
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Varshochi R et al. | ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. | 2005 | J. Biol. Chem. | pmid:15557281 |
| Alao JP et al. | Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. | 2004 | Clin. Cancer Res. | pmid:15585645 |
| Sato N et al. | Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. | 2005 | Oncogene | pmid:15592528 |
| Karasawa Y and Okisaka S | Inhibition of histone deacetylation by butyrate induces morphological changes in Y79 retinoblastoma cells. | 2004 Nov-Dec | Jpn. J. Ophthalmol. | pmid:15592778 |
| Davidson SM et al. | The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. | 2005 | Chembiochem | pmid:15593114 |
| Goeman F et al. | Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. | 2005 | Mol. Cell. Biol. | pmid:15601862 |
| Bayart E et al. | A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. | 2004 | Cancer Res. | pmid:15604258 |
| Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |
| Fujisawa K et al. | Epigenetic status and aberrant expression of the maspin gene in human hepato-biliary tract carcinomas. | 2005 | Lab. Invest. | pmid:15608662 |
| Bottardi S et al. | Onset and inheritance of abnormal epigenetic regulation in hematopoietic cells. | 2005 | Hum. Mol. Genet. | pmid:15615768 |
| Ezzat S et al. | The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. | 2005 | Mol. Endocrinol. | pmid:15618287 |
| Maxhimer JB et al. | Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). | 2005 | J. Thorac. Cardiovasc. Surg. | pmid:15632825 |
| Kondo T et al. | Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. | 2005 | Oncogene | pmid:15637589 |
| Senawong T et al. | BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. | 2005 | Arch. Biochem. Biophys. | pmid:15639232 |
| Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
| Huang W et al. | Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. | 2005 | J. Biol. Chem. | pmid:15647279 |
| Choi JH et al. | Trichostatin A attenuates airway inflammation in mouse asthma model. | 2005 | Clin. Exp. Allergy | pmid:15649272 |
| Kang J et al. | Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells. | 2005 | Toxicol In Vitro | pmid:15649630 |
| Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
| Kemp MG et al. | The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. | 2005 | Nucleic Acids Res. | pmid:15653633 |
| Huang H et al. | MEIS C termini harbor transcriptional activation domains that respond to cell signaling. | 2005 | J. Biol. Chem. | pmid:15654074 |
| Danam RP et al. | Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. | 2005 | Mol. Cancer Ther. | pmid:15657354 |
| Li Y et al. | Histone deacetylation is required for progression through mitosis in tobacco cells. | 2005 | Plant J. | pmid:15659094 |
| Marsili G et al. | Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659847 |
| Schmittwolf C et al. | In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. | 2005 | EMBO J. | pmid:15660132 |
| Endo M et al. | Novel gender-related regulation of CYP2C12 gene expression in rats. | 2005 | Mol. Endocrinol. | pmid:15661834 |
| Keen JC et al. | Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells. | 2004 | Cancer Biol. Ther. | pmid:15662126 |
| Sengupta S et al. | Tumor suppressor p53 represses transcription of RECQ4 helicase. | 2005 | Oncogene | pmid:15674334 |
| Busson M et al. | Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. | 2005 | Oncogene | pmid:15674337 |
| Ding W | [A histone deacetylase inhibitor and tumor suppressing gene p53 induction synergistically induce apoptosis of cancer cells]. | 2004 | Hokkaido Igaku Zasshi | pmid:15675303 |
| Wen J et al. | Tal1/SCL binding to pericentromeric DNA represses transcription. | 2005 | J. Biol. Chem. | pmid:15677454 |
| Yamashita Y et al. | cDNA microarray analysis in hepatocyte differentiation in Huh 7 cells. | 2004 | Cell Transplant | pmid:15690981 |
| Zhao Y et al. | Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. | 2005 | J. Exp. Biol. | pmid:15695762 |
| Illi B et al. | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. | 2005 | Circ. Res. | pmid:15705964 |
| Jalonen U et al. | Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. | 2005 | Biochem. Pharmacol. | pmid:15710351 |
| Hooven LA et al. | Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713371 |
| Chen B et al. | Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713393 |
| Duan H et al. | Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. | 2005 | Mol. Cell. Biol. | pmid:15713621 |
| Tong X et al. | Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. | 2005 | J. Biol. Chem. | pmid:15713675 |
| Gan Y et al. | Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. | 2005 | J. Biol. Chem. | pmid:15722551 |
| Endo T et al. | Changes in histone modifications during in vitro maturation of porcine oocytes. | 2005 | Mol. Reprod. Dev. | pmid:15736133 |
| Emionite L et al. | Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines. | 2004 Nov-Dec | Anticancer Res. | pmid:15736447 |
| Fan S et al. | Valproic acid enhances gene expression from viral gene transfer vectors. | 2005 | J. Virol. Methods | pmid:15737413 |
| Sonnemann J et al. | Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. | 2005 | Invest New Drugs | pmid:15744585 |
| ChuÄkin IA et al. | [Transcription of c-fos gene and DNA binding activity of transcription factor AP-1 increase upon differentiation of mouse F9 teratocarcinoma cells]. | 2004 | Tsitologiia | pmid:15747838 |
| Koh SH et al. | Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15752760 |
| Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
| Dowling M et al. | Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. | 2005 | Cancer Biol. Ther. | pmid:15753652 |
| Hu J and Colburn NH | Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. | 2005 | Mol. Cancer Res. | pmid:15755876 |
| Wagner S and Roemer K | Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. | 2005 | Biochem. Pharmacol. | pmid:15763542 |