| MeSH term | MeSH ID | Detail |
|---|---|---|
| Biliary Tract Neoplasms | D001661 | 7 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
| Zhao ZN et al. | TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC. | 2012 | PLoS ONE | pmid:23028803 |
| Tomosugi M et al. | Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. | 2012 | Cancer Sci. | pmid:22957647 |
| Lin KT et al. | HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. | 2012 | Clin. Cancer Res. | pmid:22811583 |
| Fleiss B et al. | Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. | 2012 | J Neuroinflammation | pmid:22512781 |
| Yang PM et al. | CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1. | 2012 | Epigenetics | pmid:22419072 |
| Wang C et al. | Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. | 2012 | Diabetes Metab. Res. Rev. | pmid:22228707 |
| Mostovich LA et al. | Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. | 2011 Sep-Oct | Cell Adh Migr | pmid:21975548 |
| Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
| Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
| Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
| Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
| Arany I et al. | Epigenetic modifiers exert renal toxicity through induction of p66shc. | 2011 | Anticancer Res. | pmid:21965735 |
| Hirata H et al. | Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. | 2011 | Int. J. Cancer | pmid:20549706 |
| Jafari S et al. | Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos. | 2011 | J. Assist. Reprod. Genet. | pmid:22020531 |
| Tseng AS et al. | HDAC activity is required during Xenopus tail regeneration. | 2011 | PLoS ONE | pmid:22022609 |
| Rajak H et al. | 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21875796 |
| He HM et al. | [The effects of a histone deacetylase (HDAC) inhibitor on endotoxin-induced endothelial cell injury]. | 2011 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22005560 |
| Acun T et al. | SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. | 2011 | BMC Cancer | pmid:21645397 |
| Hou J et al. | Structure-based optimization of click-based histone deacetylase inhibitors. | 2011 | Eur J Med Chem | pmid:21621883 |
| Gaub P et al. | The histone acetyltransferase p300 promotes intrinsic axonal regeneration. | 2011 | Brain | pmid:21705428 |
| Song K et al. | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. | 2011 | Cancer Biol. Ther. | pmid:21709440 |
| Hauff KD et al. | Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1. | 2011 | Lipids | pmid:21710238 |
| Zhou S et al. | Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. | 2011 | Circ. Res. | pmid:21778425 |
| Yoo YE and Ko CP | Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. | 2011 | Exp. Neurol. | pmid:21712032 |
| Qian Y et al. | DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. | 2011 | J. Biol. Chem. | pmid:21317427 |
| Zhang F et al. | Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. | 2011 | PLoS ONE | pmid:21346816 |
| Hizaki K et al. | Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. | 2011 | Mod. Pathol. | pmid:21317879 |
| Zhou X et al. | Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. | 2011 | J. Clin. Immunol. | pmid:21305388 |
| Meli M et al. | Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. | 2011 | Int. J. Oncol. | pmid:21318222 |
| Turovets N et al. | Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment. | 2011 | Differentiation | pmid:21306817 |
| Xiao J et al. | Discovery, synthesis, and biological evaluation of novel SMN protein modulators. | 2011 | J. Med. Chem. | pmid:21819082 |
| Yang H et al. | Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. | 2011 | Hepatology | pmid:21319187 |
| Patel T et al. | Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. | 2011 | Immunol. Cell Biol. | pmid:21321581 |
| Chaurasia P et al. | Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. | 2011 | Blood | pmid:21355088 |
| Furuta K et al. | The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. | 2011 | Plant Cell Physiol. | pmid:21357580 |
| Zhang CZ et al. | Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. | 2011 | Apoptosis | pmid:21468663 |
| Chen YT et al. | Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. | 2011 | Spine | pmid:21343850 |
| Lee MJ et al. | Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos. | 2011 | J. Reprod. Dev. | pmid:20834196 |
| Amoêdo ND et al. | Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. | 2011 | PLoS ONE | pmid:21789245 |
| Sengupta S et al. | Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. | 2011 | Oncogene | pmid:20856196 |
| Arzenani MK et al. | Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. | 2011 | Mol. Cell. Biol. | pmid:21791605 |
| Costa VL et al. | TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. | 2011 | Epigenetics | pmid:21847011 |
| Fu S et al. | Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. | 2011 | PLoS ONE | pmid:22132182 |
| Puppin C et al. | In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription. | 2011 | Cell Oncol (Dordr) | pmid:21290209 |
| Ishiguro K et al. | Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interaction. | 2011 | J. Immunol. | pmid:21278340 |
| Ma AN et al. | Histone deacetylation directs DNA methylation in survivin gene silencing. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21130077 |
| Pianta A et al. | Nucleophosmin delocalization in thyroid tumour cells. | 2011 | Endocr. Pathol. | pmid:21258971 |
| Gómez MC et al. | Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. | 2011 | Cell Reprogram | pmid:21718106 |
| Whitehead L et al. | Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. | 2011 | Bioorg. Med. Chem. | pmid:21723733 |