| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Taddei A et al. | The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? | 2005 | EMBO Rep. | pmid:15940285 |
| Place RF et al. | HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. | 2005 | Biochem. Pharmacol. | pmid:15950952 |
| Wooten LG and Ogretmen B | Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. | 2005 | J. Biol. Chem. | pmid:15951564 |
| Malago JJ et al. | Anti-inflammatory properties of heat shock protein 70 and butyrate on Salmonella-induced interleukin-8 secretion in enterocyte-like Caco-2 cells. | 2005 | Clin. Exp. Immunol. | pmid:15958071 |
| Whang YM et al. | Hyperacetylation enhances the growth-inhibitory effect of all-trans retinoic acid by the restoration of retinoic acid receptor beta expression in head and neck squamous carcinoma (HNSCC) cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15959780 |
| Shetty S et al. | Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. | 2005 | Mol. Cell. Biol. | pmid:15964798 |
| Yamaguchi K et al. | Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2. | 2005 | J. Biol. Chem. | pmid:15994313 |
| Zhao XY et al. | Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells. | 2005 | Cytokine | pmid:15996479 |
| Sato N et al. | Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling. | 2005 | Clin. Cancer Res. | pmid:16000561 |
| Munshi A et al. | Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. | 2005 | Clin. Cancer Res. | pmid:16000590 |
| Sng JC et al. | Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation. | 2005 | Neurosci. Lett. | pmid:16002216 |
| Kaneda R et al. | Genome-wide screening for target regions of histone deacetylases in cardiomyocytes. | 2005 | Circ. Res. | pmid:16002748 |
| Kusy S et al. | Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. | 2005 | Biochim. Biophys. Acta | pmid:16005989 |
| Ryu JK et al. | SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. | 2006 | Cancer Lett. | pmid:16009488 |
| Rho JH et al. | Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. | 2005 | Int. J. Oncol. | pmid:16010429 |
| Choi YH | Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. | 2005 | Int. J. Oncol. | pmid:16010430 |
| Xiong Y et al. | Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. | 2005 | Gynecol. Oncol. | pmid:16024066 |
| Smardová J et al. | CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. | 2005 | Differentiation | pmid:16026544 |
| Fandy TE et al. | Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. | 2005 | Neoplasia | pmid:16026644 |
| Korutla L et al. | The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. | 2005 | J. Neurochem. | pmid:16033423 |
| Danaher RJ et al. | Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells. | 2005 | J. Neurovirol. | pmid:16036811 |
| Scott SA et al. | 5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. | 2006 | Leuk. Res. | pmid:16043219 |
| Wu P et al. | Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16051188 |
| Karagiannis TC et al. | The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X. | 2005 | Cancer Biol. Ther. | pmid:16082178 |
| Su M et al. | Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells. | 2005 | J. Biol. Chem. | pmid:16087680 |
| Cho HH et al. | Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. | 2005 | J. Cell. Biochem. | pmid:16088945 |
| Cismasiu VB et al. | BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. | 2005 | Oncogene | pmid:16091750 |
| GarcÃa-Morales P et al. | Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. | 2005 | Mol. Cancer Ther. | pmid:16093438 |
| Nome RV et al. | Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death. | 2005 | Mol. Cancer Ther. | pmid:16093439 |
| Hirsch CL et al. | Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. | 2006 | Int. J. Cancer | pmid:16094635 |
| Ren C et al. | Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:16099169 |
| Blagosklonny MV et al. | Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. | 2005 | Cancer Res. | pmid:16103091 |
| Krouwels IM et al. | A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. | 2005 | J. Cell Biol. | pmid:16103223 |
| Lu Q et al. | Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. | 2005 | J. Med. Chem. | pmid:16107152 |
| Clem BF and Clark BJ | Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. | 2006 | Mol. Endocrinol. | pmid:16109738 |
| Kang JE et al. | Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1. | 2005 | Cell. Physiol. Biochem. | pmid:16121030 |
| Bradbury CA et al. | Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. | 2005 | Leukemia | pmid:16121216 |
| Uchida H et al. | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2005 | Endocrinology | pmid:16123169 |
| Somech R et al. | The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. | 2005 | J. Cell. Sci. | pmid:16129885 |
| Lin KT et al. | Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. | 2005 | J. Biomed. Sci. | pmid:16132114 |
| Zhang Y et al. | Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription. | 2005 | Mol. Cell. Biol. | pmid:16135786 |
| Shinji C et al. | Design and synthesis of phthalimide-type histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16137884 |
| Laribee RN and Klemsz MJ | Histone H4 HDAC activity is necessary for expression of the PU.1 gene. | 2005 | Biochim. Biophys. Acta | pmid:16139904 |
| Hofmann A et al. | Epigenetic regulation of lentiviral transgene vectors in a large animal model. | 2006 | Mol. Ther. | pmid:16140581 |
| Choi JH et al. | Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141407 |
| Ishihara K | [Role of eosinophils in allergic inflammation]. | 2005 | Yakugaku Zasshi | pmid:16141691 |
| Yanada M et al. | Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. | 2005 | Oncol. Rep. | pmid:16142337 |
| Young JC et al. | Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. | 2004 | Cytotherapy | pmid:16146885 |
| Valenzuela-Fernández A et al. | Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. | 2005 | Mol. Biol. Cell | pmid:16148047 |
| Curtin BF et al. | Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. | 2005 | J. Cell. Biochem. | pmid:16149071 |