| MeSH term | MeSH ID | Detail |
|---|---|---|
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shi QQ et al. | Effect of trichostatin A on anti HepG2 liver carcinoma cells: inhibition of HDAC activity and activation of Wnt/β-Catenin signaling. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25292076 |
| Zohre S et al. | Trichostatin A-induced apoptosis is mediated by Kruppel-like factor 4 in ovarian and lung cancer. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25169491 |
| Zhang QC et al. | Histone deacetylase inhibitor trichostatin A enhances anti-tumor effects of docetaxel or erlotinib in A549 cell line. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22994780 |
| Bao Y et al. | Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. | 2009 | Atherosclerosis | pmid:18930459 |
| Li J et al. | Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. | 2010 | Autophagy | pmid:20543569 |
| Liu YL et al. | Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma. | 2010 | Autophagy | pmid:20962572 |
| Knobloch J et al. | Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:23981542 |
| Miyagawa K et al. | Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice. | 2012 | Behav. Brain Res. | pmid:22963996 |
| Moldrich RX et al. | Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. | 2013 | Behav. Brain Res. | pmid:24103642 |
| Lattal KM et al. | Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. | 2007 | Behav. Neurosci. | pmid:17907845 |
| Hosseinkhani M et al. | Trichostatin A induces myocardial differentiation of monkey ES cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17368572 |
| Kim YS et al. | Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22634317 |
| Oger F et al. | The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18977200 |
| Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
| Higashi T et al. | Histone H2A mobility is regulated by its tails and acetylation of core histone tails. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17445770 |
| Gan Y et al. | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16338217 |
| Kishigami S et al. | Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16356478 |
| Hagiwara H et al. | Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22019851 |
| Park KS et al. | Histone modification-mediated Lhx2 gene expression. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23036195 |
| Wang X et al. | Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25434997 |
| Heo H et al. | Suppression of caspase-11 expression by histone deacetylase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013432 |
| Liu Z et al. | Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801101 |
| Akiba Y et al. | Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20170631 |
| Bigl M et al. | Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18938139 |
| Sugita K et al. | A novel compound, depudecin, induces production of transformation to the flat phenotype of NIH3T3 cells transformed by ras-oncogene. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1731795 |
| Benny Klimek ME et al. | Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20036643 |
| Li H and Wu X | Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474507 |
| Choi HS et al. | Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12200149 |
| Sayan BS et al. | Induction of TAp63 by histone deacetylase inhibitors. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20043870 |
| Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
| Ghosh AK et al. | Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17234156 |
| Matsubara K et al. | Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23567968 |
| Zhou X et al. | Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22425986 |
| Choi S et al. | Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23665318 |
| Gray SG and Ekström TJ | Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9571167 |
| Sobue S et al. | Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27687545 |
| Maehara K et al. | Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12083788 |
| Wang XQ et al. | Histone deacetylase inhibition results in decreased macrophage CD9 expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12056820 |
| Hejnar J et al. | Demethylation of host-cell DNA at the site of avian retrovirus integration. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14623319 |
| Hirose N et al. | ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19422799 |
| Ghosh AK et al. | MBP-1 physically associates with histone deacetylase for transcriptional repression. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403782 |
| Kim HS et al. | Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14651963 |
| Sun P et al. | Effect of trichostatin A on Burkitt's lymphoma cells: Inhibition of EPS8 activity through Phospho-Erk1/2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29462617 |
| Ma AN et al. | Histone deacetylation directs DNA methylation in survivin gene silencing. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21130077 |
| Kusakabe M et al. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19878646 |
| Lu ZP et al. | Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15781251 |
| Iacobazzi V et al. | Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706393 |
| Kuusisto E et al. | Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162503 |
| Shi H et al. | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23201405 |
| Hashii M et al. | Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17367762 |