| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Neoplasms | D001932 | 15 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Cat Diseases | D002371 | 12 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wittich S et al. | Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. | 2002 | J. Med. Chem. | pmid:12109913 |
| Toyooka S et al. | Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures. | 2002 | Clin. Cancer Res. | pmid:12114433 |
| Waterborg JH and Kapros T | Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa. | 2002 | Biochem. Cell Biol. | pmid:12123281 |
| Mikkelsen IM et al. | Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif. | 2002 | Biochem. Pharmacol. | pmid:12123752 |
| Petti MC et al. | Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies. | 2002 | Blood | pmid:12130525 |
| Fang D et al. | Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. | 2002 | Nucleic Acids Res. | pmid:12136092 |
| Zschocke J et al. | Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells. | 2002 | J. Biol. Chem. | pmid:12138116 |
| Yu Z et al. | Histone deacetylases augment cytokine induction of the iNOS gene. | 2002 | J. Am. Soc. Nephrol. | pmid:12138131 |
| Li J et al. | Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. | 2002 | Mol. Cell. Biol. | pmid:12138181 |
| Rahman I et al. | Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. | 2002 May-Jun | Mol. Cell. Biochem. | pmid:12162440 |
| Noss KR et al. | Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. | 2002 May-Jun | Anticancer Res. | pmid:12168830 |
| Rombouts K et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. | 2002 | Exp. Cell Res. | pmid:12169274 |
| Aapola U et al. | Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. | 2002 | Nucleic Acids Res. | pmid:12177302 |
| Avram D et al. | COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. | 2002 | Biochem. J. | pmid:12196208 |
| Guo Y et al. | Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. | 2002 | J. Biol. Chem. | pmid:12198113 |
| Choi HS et al. | Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12200149 |
| Maecker HL et al. | Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. | 2002 | Cancer Cell | pmid:12204534 |
| Kostyniuk CL et al. | The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. | 2002 | Oncogene | pmid:12214274 |
| Hall IM et al. | Establishment and maintenance of a heterochromatin domain. | 2002 | Science | pmid:12215653 |
| Lynch CA et al. | Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. | 2002 | Mol. Cancer | pmid:12234381 |