| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Neoplasms | D001932 | 15 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Cat Diseases | D002371 | 12 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hsieh TH et al. | Phthalates stimulate the epithelial to mesenchymal transition through an HDAC6-dependent mechanism in human breast epithelial stem cells. | 2012 | Toxicol. Sci. | pmid:22552774 |
| Vinken M et al. | Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. | 2006 | Toxicol. Sci. | pmid:16531468 |
| Scholpa NE et al. | Epigenetic changes in p21 expression in renal cells after exposure to bromate. | 2014 | Toxicol. Sci. | pmid:25015661 |
| Jergil M et al. | Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. | 2011 | Toxicol. Sci. | pmid:21427059 |
| Wu Y et al. | Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity. | 2018 | Toxicol. Sci. | pmid:29301062 |
| Kang J et al. | Nickel-induced histone hypoacetylation: the role of reactive oxygen species. | 2003 | Toxicol. Sci. | pmid:12773760 |
| Olaharski AJ et al. | The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro. | 2006 | Toxicol. Sci. | pmid:16857700 |
| Beedanagari SR et al. | Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. | 2010 | Toxicol. Lett. | pmid:20116417 |
| Nakajima M et al. | Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. | 2003 | Toxicol. Lett. | pmid:12927368 |
| Liu Y et al. | MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. | 2013 | Toxicol. Lett. | pmid:23770000 |
| Vrzal R et al. | Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia? | 2011 | Toxicol. Lett. | pmid:21115105 |
| Bebenek IG et al. | CYP2S1 is negatively regulated by corticosteroids in human cell lines. | 2012 | Toxicol. Lett. | pmid:22155357 |
| Singh RD et al. | Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. | 2015 | Toxicol. Lett. | pmid:26008221 |
| Xia B et al. | Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. | 2011 | Toxicol. Lett. | pmid:21641978 |
| Gao A et al. | Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression. | 2010 | Toxicol. Lett. | pmid:20230882 |
| Henkens T et al. | Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes. | 2008 | Toxicol. Lett. | pmid:18358644 |
| Yan Y et al. | Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12902198 |
| Li X et al. | Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27396813 |
| Wu TC et al. | The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26768552 |
| Cheng X et al. | Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24747804 |