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Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. |
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Trichostatin A protects against intestinal injury in rats with acute liver failure. |
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Trichostatin A inhibits inflammation in phorbol myristate acetate‑induced macrophages by regulating the acetylation of histone and/or non‑histone proteins. |
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Mol Med Rep |
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Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. |
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Histone deacetylase inhibition abolishes stress-induced spatial memory impairment. |
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The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. |
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Genistein and Trichostatin A Induction of Estrogen Receptor Alpha Gene Expression, Apoptosis and Cell Growth Inhibition in Hepatocellular Carcinoma HepG 2 Cells |
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Biochem. Biophys. Res. Commun. |
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Mol. Pharmacol. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. |
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Epigenetics |
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Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor-like effects on ER-driven genes in MCF7 breast tumor cells. |
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Mol. Cell. Endocrinol. |
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Cell Rep |
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TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos. |
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PLoS ONE |
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PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. |
2017 |
Oncotarget |
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Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression. |
2017 |
Int J Parasitol Drugs Drug Resist |
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Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. |
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Mol. Pharmacol. |
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HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. |
2017 |
Cancer Genomics Proteomics |
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The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. |
2017 |
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Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. |
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Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. |
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Neuropharmacology |
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Mol. Syst. Biol. |
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Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. |
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Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. |
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TSA increases C/EBP‑α expression by increasing its lysine acetylation in hepatic stellate cells. |
2017 |
Mol Med Rep |
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Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. |
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Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease. |
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Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). |
2017 |
Int J Nanomedicine |
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Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. |
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J Vis Exp |
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Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite . |
2017 |
Front Cell Infect Microbiol |
pmid:28791254
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Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. |
2017 |
Oncol. Rep. |
pmid:28713892
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Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury. |
2017 |
Cell Death Dis |
pmid:29072686
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Androutsopoulos VP and Spandidos DA |
Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. |
2017 |
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Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. |
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