Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ashburner BP et al. | The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. | 2001 | Mol. Cell. Biol. | pmid:11564889 |
Sachs LM et al. | Involvement of histone deacetylase at two distinct steps in gene regulation during intestinal development in Xenopus laevis. | 2001 | Dev. Dyn. | pmid:11668605 |
Amann JM et al. | ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. | 2001 | Mol. Cell. Biol. | pmid:11533236 |
Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
Bovenzi V and Momparler RL | Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. | 2001 | Cancer Chemother. Pharmacol. | pmid:11488527 |
Franco PJ et al. | The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. | 2001 | Mol. Endocrinol. | pmid:11463856 |
Sutherland JE et al. | The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells. | 2001 | Mutat. Res. | pmid:11470494 |
Takakura M et al. | Telomerase activation by histone deacetylase inhibitor in normal cells. | 2001 | Nucleic Acids Res. | pmid:11452025 |
Ferraro M et al. | Involvement of histone H4 acetylation in the epigenetic inheritance of different activity states of maternally and paternally derived genomes in the mealybug Planococcus citri. | 2001 | Chromosoma | pmid:11453559 |
Marianna P et al. | Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. | 2001 | Haematologica | pmid:11454524 |
Cho JH et al. | DNA methylation regulates placental lactogen I gene expression. | 2001 | Endocrinology | pmid:11459782 |
Walker GE et al. | Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. | 2001 | Endocrinology | pmid:11517158 |
Jorgensen JS and Nilson JH | AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. | 2001 | Mol. Endocrinol. | pmid:11518798 |
Phiel CJ et al. | Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. | 2001 | J. Biol. Chem. | pmid:11473107 |
Sundqvist A et al. | Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription. | 2001 | Exp. Cell Res. | pmid:11478854 |
Jacob AL et al. | Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5. | 2001 | J. Biol. Chem. | pmid:11479297 |
Pujuguet P et al. | Trichostatin A inhibits beta-casein expression in mammary epithelial cells. | 2001 | J. Cell. Biochem. | pmid:11746508 |
Matsusue K et al. | Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. | 2001 | DNA Cell Biol. | pmid:11749719 |
Lavelle D et al. | Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. | 2001 | Am. J. Hematol. | pmid:11754398 |
Williams RJ | Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis. | 2001 | Expert Opin Investig Drugs | pmid:11785457 |
Benjamin D and Jost JP | Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation. | 2001 | Nucleic Acids Res. | pmid:11522830 |
Li J et al. | Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. | 2001 | Mol. Cell. Biol. | pmid:11689710 |
Rashid SF et al. | Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A. | 2001 | Oncogene | pmid:11313934 |
Bachl J et al. | Increased transcription levels induce higher mutation rates in a hypermutating cell line. | 2001 | J. Immunol. | pmid:11290786 |
Mishra N et al. | Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226290 |
Ding BC et al. | Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. | 2001 | Biochem. Pharmacol. | pmid:11266651 |
Segev H et al. | Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development. | 2001 | Zygote | pmid:11358320 |
Archer SY et al. | p21 gene regulation during enterocyte differentiation. | 2001 | J. Surg. Res. | pmid:11368530 |
Ma J et al. | Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression. | 2001 | Biol. Reprod. | pmid:11369600 |
Della Ragione F et al. | Genes modulated by histone acetylation as new effectors of butyrate activity. | 2001 | FEBS Lett. | pmid:11423116 |
Maës J et al. | Chromatin remodeling at the Ig loci prior to V(D)J recombination. | 2001 | J. Immunol. | pmid:11441093 |
Wang H et al. | Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. | 2001 | Science | pmid:11387442 |
Klar AJ et al. | A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. | 2001 | Genetics | pmid:11404352 |
Massa S et al. | 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. | 2001 | J. Med. Chem. | pmid:11405644 |
Setlow JK et al. | Evidence for gene silencing in Haemophilus influenzae. | 2001 | Mutat. Res. | pmid:11406170 |
Feng YQ et al. | Position effects are influenced by the orientation of a transgene with respect to flanking chromatin. | 2001 | Mol. Cell. Biol. | pmid:11113204 |
Mehra-Chaudhary R et al. | Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. | 2001 | Biochem. J. | pmid:11115394 |
Osborne A et al. | Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. | 2001 | Mol. Cell. Biol. | pmid:11533238 |
Kosugi H et al. | In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice. | 2001 | Jpn. J. Cancer Res. | pmid:11376562 |
Kuusisto E et al. | Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162503 |
Grandjean V et al. | Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain. | 2001 | FEBS Lett. | pmid:11163765 |
Lizcano F et al. | Cell type-specific roles of histone deacetylase in TR ligand-independent transcriptional repression. | 2001 | Mol. Cell. Endocrinol. | pmid:11165035 |
Nervi C et al. | Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. | 2001 | Cancer Res. | pmid:11245412 |
Zhu WG et al. | DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | 2001 | Cancer Res. | pmid:11245429 |
Muth V et al. | Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. | 2001 | EMBO J. | pmid:11250901 |
Laribee RN and Klemsz MJ | Loss of PU.1 expression following inhibition of histone deacetylases. | 2001 | J. Immunol. | pmid:11673528 |
Biade S et al. | Chemical agents that promote chromatin compaction radiosensitize tumour cells. | 2001 | Int. J. Radiat. Biol. | pmid:11682008 |
Mishra SK et al. | Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. | 2001 | FEBS Lett. | pmid:11682064 |
Sharma M and Sun Z | 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription. | 2001 | Mol. Endocrinol. | pmid:11682623 |