Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kotantaki P and Mosialos G | The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. | 2016 | Cell Biochem. Funct. | pmid:27570065 |
Shao A et al. | Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. | 2016 | Mol. Neurobiol. | pmid:25399954 |
DÃaz-Núñez M et al. | Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. | 2016 | BMC Cancer | pmid:27549189 |
Sugiyama KI et al. | Epigenetic mutagen as histone modulator can be detected by yeast flocculation. | 2016 | Mutagenesis | pmid:27549112 |
Zhang XF et al. | Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. | 2016 | Int J Mol Sci | pmid:27548148 |
Gehring KB et al. | Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. | 2016 | Learn. Mem. | pmid:27084927 |
Li QQ et al. | Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. | 2016 | Int. J. Oncol. | pmid:27082124 |
Duclot F et al. | Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster). | 2016 | Horm Behav | pmid:27074037 |
Toki S et al. | The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. | 2016 | Thorax | pmid:27071418 |
Ho TT et al. | Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. | 2016 | Int J Biochem Mol Biol | pmid:27570640 |
Yeh BW et al. | Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26589485 |
Asgar MA et al. | Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines. | 2016 | Int. J. Oncol. | pmid:26575528 |
Ranganathan P et al. | Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. | 2016 | Kidney Int. | pmid:26509586 |
Takamatsu G et al. | Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27939885 |
Aquea F et al. | Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27993678 |
Shinde V et al. | Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox and STOP-Tox tests. | 2017 | Arch. Toxicol. | pmid:27188386 |
Choiniere J et al. | Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. | 2017 | Mol. Pharmacol. | pmid:28003426 |
Porter NJ et al. | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29203661 |
Bagheri-Hosseinabadi Z et al. | Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor. | 2017 | Biomed Eng Online | pmid:29169361 |
Lam YM et al. | Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo. | 2017 | Int. J. Hematol. | pmid:27531147 |
Good KV et al. | Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. | 2017 | Epigenetics | pmid:29099289 |
Zhang Z et al. | Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29054681 |
Song Y et al. | Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis. | 2017 | Plant Signal Behav | pmid:29027833 |
Fujikawa J et al. | Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes. | 2017 | Cell Tissue Res. | pmid:28856432 |
Campo VA | Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression. | 2017 | Int J Parasitol Drugs Drug Resist | pmid:28038431 |
Alqinyah M et al. | Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. | 2017 | Mol. Pharmacol. | pmid:28031332 |
Mazzio EA and Soliman KF | HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. | 2017 | Cancer Genomics Proteomics | pmid:28031235 |
Duan H et al. | The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. | 2017 | Placenta | pmid:28012453 |
Mengel A et al. | Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases. | 2017 | Plant Physiol. | pmid:27980017 |
Jia L et al. | Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. | 2017 | Oncol. Rep. | pmid:27878285 |
Huynh NC et al. | Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells. | 2017 | Bone | pmid:27871909 |
Wittayarat M et al. | Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A. | 2017 | Anim. Sci. J. | pmid:27506538 |
Zapletal O et al. | Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. | 2017 | Arch. Toxicol. | pmid:27830268 |
Anantharaju PG et al. | Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). | 2017 | PLoS ONE | pmid:29190639 |
Guo Y et al. | Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. | 2017 | Int. J. Mol. Med. | pmid:28849190 |
Tao LL et al. | TSA increases C/EBP‑α expression by increasing its lysine acetylation in hepatic stellate cells. | 2017 | Mol Med Rep | pmid:28849174 |
Kudo K et al. | Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. | 2017 | J. Am. Chem. Soc. | pmid:28497964 |
Lin W et al. | Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease. | 2017 | Kidney Int. | pmid:28416226 |
Zhang XF et al. | Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). | 2017 | Int J Nanomedicine | pmid:29075115 |
Simões-Pires CA et al. | Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. | 2017 | J Vis Exp | pmid:28829415 |
Ngwa CJ et al. | Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite . | 2017 | Front Cell Infect Microbiol | pmid:28791254 |
Wang SC et al. | Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. | 2017 | Oncol. Rep. | pmid:28713892 |
Pérez-Garrastachu M et al. | Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition. | 2017 | Nucleus | pmid:28696859 |
Opiela J et al. | In vitro development and cytological quality of inter-species (porcine→bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of adult mesenchymal stem cells. | 2017 | Theriogenology | pmid:28583605 |
Hou X et al. | HDAC inhibitor TSA ameliorates mechanical hypersensitivity and potentiates analgesic effect of morphine in a rat model of bone cancer pain by restoring μ-opioid receptor in spinal cord. | 2017 | Brain Res. | pmid:28559159 |
Ilicic M et al. | Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium. | 2017 | Biomed Res Int | pmid:28540297 |
Ma T et al. | Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury. | 2017 | Cell Death Dis | pmid:29072686 |
Androutsopoulos VP and Spandidos DA | Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. | 2017 | Oncol. Rep. | pmid:29039546 |
Anantharaju PG et al. | Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). | 2017 | Cancer Biol. Ther. | pmid:28506198 |
Hichino A et al. | Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. | 2017 | J. Biol. Chem. | pmid:28057758 |