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Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. |
2006 |
Ann. Thorac. Surg. |
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2006 |
Ann. Thorac. Surg. |
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High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. |
2006 |
J. Clin. Pathol. |
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Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. |
2006 |
Mol. Cancer Res. |
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Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes. |
2006 |
Reproduction |
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Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. |
2006 |
Int. J. Radiat. Oncol. Biol. Phys. |
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Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. |
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Oncol. Rep. |
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Alao JP et al. |
Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. |
2006 |
Mol. Cancer |
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An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. |
2006 |
Cancer Res. |
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Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. |
2006 |
Cancer Biol. Ther. |
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Williams SA et al. |
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. |
2006 |
EMBO J. |
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Deacetylase inhibitors aid recovery in muscular dystrophy. |
2006 |
Lancet Neurol |
pmid:17089447
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Kiefer J et al. |
Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. |
2006 |
Br. J. Nutr. |
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Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. |
2006 |
Dev. Biol. |
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Mogal A and Abdulkadir SA |
Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. |
2006 |
Mol. Cell. Probes |
pmid:16326072
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Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16338217
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Nishiyama A et al. |
Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. |
2006 |
Mol. Biol. Cell |
pmid:16339075
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Trapp J et al. |
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. |
2006 |
J. Med. Chem. |
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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. |
2006 |
Mol. Cell. Biol. |
pmid:16354677
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Kishigami S et al. |
Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. |
2006 |
Biochem. Biophys. Res. Commun. |
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Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. |
2006 |
Endocr. Relat. Cancer |
pmid:17158768
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TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome. |
2006 |
Cancer Biol. Ther. |
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Hishikawa K and Fujita T |
[Basic research for renal regeneration]. |
2006 |
Nippon Rinsho |
pmid:16895225
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Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. |
2006 |
J. Neurochem. |
pmid:16895577
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The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. |
2006 |
Cell Death Differ. |
pmid:16557274
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Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia. |
2006 |
Neurochem. Int. |
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Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. |
2006 |
FASEB J. |
pmid:16246867
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Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. |
2006 |
Invest. Ophthalmol. Vis. Sci. |
pmid:16799012
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Pampalakis G and Sotiropoulou G |
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. |
2006 |
Biol. Chem. |
pmid:16800739
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Wang Y et al. |
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. |
2006 |
Arthritis Rheum. |
pmid:16802366
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Morinobu A et al. |
Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. |
2006 |
J. Rheumatol. |
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Involvement of caspase activation and mitochondrial stress in trichostatin A-induced apoptosis of Burkitt's lymphoma cell line, Akata. |
2006 |
J. Cell. Biochem. |
pmid:16817225
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RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. |
2006 |
Cancer Res. |
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The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. |
2006 |
J. Cell. Biochem. |
pmid:16265664
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Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. |
2006 |
Cancer Res. |
pmid:16818640
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Mori T et al. |
Estrogen receptor-alpha methylation predicts melanoma progression. |
2006 |
Cancer Res. |
pmid:16818643
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Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. |
2006 |
Int. J. Oncol. |
pmid:16820886
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Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice. |
2006 |
Plant Cell Physiol. |
pmid:16774928
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Dannenberg LO et al. |
Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. |
2006 |
Alcohol. Clin. Exp. Res. |
pmid:16737450
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Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. |
2006 |
Mol. Biol. Cell |
pmid:16738306
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HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. |
2006 |
Exp. Cell Res. |
pmid:16739251
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Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. |
2006 |
Cancer Res. |
pmid:16740727
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Nusinzon I and Horvath CM |
Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. |
2006 |
Mol. Cell. Biol. |
pmid:16581785
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Identification of novel target genes by an epigenetic reactivation screen of renal cancer. |
2006 |
Cancer Res. |
pmid:16707423
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Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. |
2006 |
Cancer Res. |
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Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. |
2006 |
Virol. J. |
pmid:16603064
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E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. |
2006 |
Oncogene |
pmid:16158053
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Hwang DY and Ismail-Beigi F |
Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. |
2006 |
Am. J. Physiol., Cell Physiol. |
pmid:16162661
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Kim MY et al. |
Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. |
2006 |
Mol. Endocrinol. |
pmid:16497729
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Leng Y and Chuang DM |
Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. |
2006 |
J. Neurosci. |
pmid:16837598
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Aung HT et al. |
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. |
2006 |
FASEB J. |
pmid:16816106
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Clem BF and Clark BJ |
Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. |
2006 |
Mol. Endocrinol. |
pmid:16109738
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Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. |
2006 |
J. Med. Chem. |
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NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. |
2006 |
Pharmacol. Res. |
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Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. |
2006 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:17008592
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Baqir S and Smith LC |
Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. |
2006 |
Cloning Stem Cells |
pmid:17009896
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[Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. |
2006 |
Ai Zheng |
pmid:16965673
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Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. |
2006 |
Clin. Cancer Res. |
pmid:16609009
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SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. |
2006 |
Cancer Lett. |
pmid:16009488
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Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. |
2006 |
BMC Cancer |
pmid:16930472
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Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. |
2006 |
J. Med. Chem. |
pmid:16884291
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Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. |
2006 |
Cancer Res. |
pmid:16885346
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Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. |
2006 |
Protist |
pmid:16839811
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MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16847267
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Zaveri NT et al. |
Regulation of the prepronociceptin gene and its effect on neuronal differentiation. |
2006 |
Gene |
pmid:16935438
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Dokras A et al. |
Epigenetic regulation of maspin expression in the human placenta. |
2006 |
Mol. Hum. Reprod. |
pmid:16936308
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Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis. |
2006 |
Br. J. Haematol. |
pmid:16939493
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Methylation mediated silencing of TMS1/ASC gene in prostate cancer. |
2006 |
Mol. Cancer |
pmid:16848908
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Puppin C et al. |
HEX expression and localization in normal mammary gland and breast carcinoma. |
2006 |
BMC Cancer |
pmid:16854221
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Dannenberg LO and Edenberg HJ |
Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. |
2006 |
BMC Genomics |
pmid:16854234
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The extracellular release of HMGB1 during apoptotic cell death. |
2006 |
Am. J. Physiol., Cell Physiol. |
pmid:16855214
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Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. |
2006 |
Clin. Cancer Res. |
pmid:16467109
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Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. |
2006 |
Clin. Gastroenterol. Hepatol. |
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Tumor suppressor p53 regulates heparanase gene expression. |
2006 |
Oncogene |
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Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. |
2006 |
Nucleic Acids Res. |
pmid:16452299
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Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. |
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Biochim. Biophys. Acta |
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Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. |
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J. Neurosci. |
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Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. |
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Virol. J. |
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HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. |
2007 |
Exp. Cell Res. |
pmid:17555745
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Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. |
2007 |
Biochim. Biophys. Acta |
pmid:17555830
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Effect of histone deacetylase inhibitors on the cell nucleus and nucleolus of leukemic myeloblasts in vitro - a cytochemical study. |
2007 |
Acta Histochem. |
pmid:17559910
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Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. |
2007 |
Int. J. Cancer |
pmid:17019711
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Design and synthesis of a potent histone deacetylase inhibitor. |
2007 |
J. Med. Chem. |
pmid:17419603
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Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. |
2007 |
Mol. Cell. Biol. |
pmid:17452465
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Piotrowska H and Jagodzinski PP |
Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. |
2007 |
Biomed. Pharmacother. |
pmid:17498915
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Iliopoulos D et al. |
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. |
2007 |
Ann. Rheum. Dis. |
pmid:17502362
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Zhang R et al. |
HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. |
2007 |
Mol. Cell. Biol. |
pmid:17101789
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Dai B and Rasmussen TP |
Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. |
2007 |
Stem Cells |
pmid:17641388
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Kaida D et al. |
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. |
2007 |
Nat. Chem. Biol. |
pmid:17643111
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Splicing factor SF3b as a target of the antitumor natural product pladienolide. |
2007 |
Nat. Chem. Biol. |
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Kang JH et al. |
Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. |
2007 |
Exp. Mol. Med. |
pmid:17603295
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Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. |
2007 |
Cancer Res. |
pmid:18056459
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Sourlingas TG et al. |
Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. |
2007 |
Ann. N. Y. Acad. Sci. |
pmid:18056955
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Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. |
2007 |
Chin. Med. J. |
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Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. |
2007 |
J. Biol. Chem. |
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Januchowski R and Jagodzinski PP |
Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. |
2007 |
Int. Immunopharmacol. |
pmid:17178387
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Cras A et al. |
Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. |
2007 |
Oncogene |
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Honda H et al. |
Regulation of the CLDN3 gene in ovarian cancer cells. |
2007 |
Cancer Biol. Ther. |
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Renthal W et al. |
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. |
2007 |
Neuron |
pmid:17988634
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Carén H et al. |
Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. |
2007 |
Br. J. Cancer |
pmid:17940511
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