trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Lymphoma, Large-Cell, Anaplastic D017728 3 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Rhabdomyosarcoma, Alveolar D018232 2 associated lipids
Rhabdomyosarcoma, Embryonal D018233 1 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Cystadenoma, Serous D018293 1 associated lipids
Rhabdoid Tumor D018335 1 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Roseolovirus Infections D019349 1 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Myopathy, Central Core D020512 1 associated lipids
Stroke D020521 32 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Mastocytoma D034801 3 associated lipids
Genomic Instability D042822 7 associated lipids
Atherosclerosis D050197 85 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Small Cell Lung Carcinoma D055752 2 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Capsule Opacification D058442 1 associated lipids
Inflammatory Breast Neoplasms D058922 2 associated lipids
Visceral Pain D059265 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Adenomyosis D062788 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Mukhopadhyay NK et al. Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. 2006 Ann. Thorac. Surg. pmid:16488717
Swanson S Invited commentary. 2006 Ann. Thorac. Surg. pmid:16488718
Song YF et al. High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. 2006 J. Clin. Pathol. pmid:16489177
Rokhlin OW et al. Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. 2006 Mol. Cancer Res. pmid:16513842
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Sah NK et al. Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. 2006 Int. J. Radiat. Oncol. Biol. Phys. pmid:17011457
Kumar KS et al. Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. 2006 Oncol. Rep. pmid:17016591
Alao JP et al. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. 2006 Mol. Cancer pmid:17018141
Zhao LY et al. An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. 2006 Cancer Res. pmid:17018599
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Williams SA et al. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. 2006 EMBO J. pmid:16319923
Anderson I Deacetylase inhibitors aid recovery in muscular dystrophy. 2006 Lancet Neurol pmid:17089447
Kiefer J et al. Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. 2006 Br. J. Nutr. pmid:17092367
Kishigami S et al. Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. 2006 Dev. Biol. pmid:16325170
Mogal A and Abdulkadir SA Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. 2006 Mol. Cell. Probes pmid:16326072
Gan Y et al. Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. 2006 Biochem. Biophys. Res. Commun. pmid:16338217
Nishiyama A et al. Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. 2006 Mol. Biol. Cell pmid:16339075
Trapp J et al. Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. 2006 J. Med. Chem. pmid:17149860
Solomon JM et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. 2006 Mol. Cell. Biol. pmid:16354677
Kishigami S et al. Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. 2006 Biochem. Biophys. Res. Commun. pmid:16356478
Baradari V et al. Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. 2006 Endocr. Relat. Cancer pmid:17158768
Taghiyev AF et al. TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome. 2006 Cancer Biol. Ther. pmid:17110788
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Rebbaa A et al. The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. 2006 Cell Death Differ. pmid:16557274
Suuronen T et al. Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia. 2006 Neurochem. Int. pmid:16797784
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Wallace DM et al. Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16799012
Pampalakis G and Sotiropoulou G Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. 2006 Biol. Chem. pmid:16800739
Wang Y et al. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. 2006 Arthritis Rheum. pmid:16802366
Morinobu A et al. Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. 2006 J. Rheumatol. pmid:16755652
Son YO et al. Involvement of caspase activation and mitochondrial stress in trichostatin A-induced apoptosis of Burkitt's lymphoma cell line, Akata. 2006 J. Cell. Biochem. pmid:16817225
Lau QC et al. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. 2006 Cancer Res. pmid:16818622
Peng C et al. The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. 2006 J. Cell. Biochem. pmid:16265664
Foltz G et al. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. 2006 Cancer Res. pmid:16818640
Mori T et al. Estrogen receptor-alpha methylation predicts melanoma progression. 2006 Cancer Res. pmid:16818643
Sato K et al. Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. 2006 Int. J. Oncol. pmid:16820886
Tsuji H et al. Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice. 2006 Plant Cell Physiol. pmid:16774928
Dannenberg LO et al. Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. 2006 Alcohol. Clin. Exp. Res. pmid:16737450
Cabrero JR et al. Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. 2006 Mol. Biol. Cell pmid:16738306
Vulcano F et al. HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. 2006 Exp. Cell Res. pmid:16739251
Qi H and Ratnam M Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. 2006 Cancer Res. pmid:16740727
Nusinzon I and Horvath CM Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. 2006 Mol. Cell. Biol. pmid:16581785
Ibanez de Caceres I et al. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. 2006 Cancer Res. pmid:16707423
Imre G et al. Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. 2006 Cancer Res. pmid:16707469
Jaalouk DE et al. Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. 2006 Virol. J. pmid:16603064
Lu Z et al. E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. 2006 Oncogene pmid:16158053
Hwang DY and Ismail-Beigi F Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. 2006 Am. J. Physiol., Cell Physiol. pmid:16162661
Kim MY et al. Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. 2006 Mol. Endocrinol. pmid:16497729
Leng Y and Chuang DM Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. 2006 J. Neurosci. pmid:16837598
Aung HT et al. LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. 2006 FASEB J. pmid:16816106
Clem BF and Clark BJ Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. 2006 Mol. Endocrinol. pmid:16109738
Mai A et al. Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. 2006 J. Med. Chem. pmid:17004718
Yao J et al. NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. 2006 Pharmacol. Res. pmid:17005413
Inoue K et al. Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:17008592
Baqir S and Smith LC Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. 2006 Cloning Stem Cells pmid:17009896
Hong ZY et al. [Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. 2006 Ai Zheng pmid:16965673
Banwell CM et al. Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. 2006 Clin. Cancer Res. pmid:16609009
Ryu JK et al. SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. 2006 Cancer Lett. pmid:16009488
Mühlethaler-Mottet A et al. Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. 2006 BMC Cancer pmid:16930472
Suzuki T et al. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. 2006 J. Med. Chem. pmid:16884291
Kim TY et al. Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. 2006 Cancer Res. pmid:16885346
Kimura N et al. Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. 2006 Protist pmid:16839811
Monte M et al. MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16847267
Zaveri NT et al. Regulation of the prepronociceptin gene and its effect on neuronal differentiation. 2006 Gene pmid:16935438
Dokras A et al. Epigenetic regulation of maspin expression in the human placenta. 2006 Mol. Hum. Reprod. pmid:16936308
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Puppin C et al. HEX expression and localization in normal mammary gland and breast carcinoma. 2006 BMC Cancer pmid:16854221
Dannenberg LO and Edenberg HJ Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. 2006 BMC Genomics pmid:16854234
Bell CW et al. The extracellular release of HMGB1 during apoptotic cell death. 2006 Am. J. Physiol., Cell Physiol. pmid:16855214
Kim IA et al. Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. 2006 Clin. Cancer Res. pmid:16467109
Osborn NK et al. Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. 2006 Clin. Gastroenterol. Hepatol. pmid:16469682
Baraz L et al. Tumor suppressor p53 regulates heparanase gene expression. 2006 Oncogene pmid:16474844
Gialitakis M et al. Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. 2006 Nucleic Acids Res. pmid:16452299
Kwon HS et al. Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. 2006 Mar-Apr Biochim. Biophys. Acta pmid:16757381
Vecsey CG et al. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. 2007 J. Neurosci. pmid:17553985
Pinnoji RC et al. Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. 2007 Virol. J. pmid:17555596
Khan Z et al. HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. 2007 Exp. Cell Res. pmid:17555745
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Smetana K et al. Effect of histone deacetylase inhibitors on the cell nucleus and nucleolus of leukemic myeloblasts in vitro - a cytochemical study. 2007 Acta Histochem. pmid:17559910
Cantor JP et al. Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. 2007 Int. J. Cancer pmid:17019711
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Hwang CK et al. Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. 2007 Mol. Cell. Biol. pmid:17452465
Piotrowska H and Jagodzinski PP Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. 2007 Biomed. Pharmacother. pmid:17498915
Iliopoulos D et al. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. 2007 Ann. Rheum. Dis. pmid:17502362
Zhang R et al. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. 2007 Mol. Cell. Biol. pmid:17101789
Dai B and Rasmussen TP Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. 2007 Stem Cells pmid:17641388
Kaida D et al. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. 2007 Nat. Chem. Biol. pmid:17643111
Kotake Y et al. Splicing factor SF3b as a target of the antitumor natural product pladienolide. 2007 Nat. Chem. Biol. pmid:17643112
Kang JH et al. Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. 2007 Exp. Mol. Med. pmid:17603295
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Sourlingas TG et al. Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. 2007 Ann. N. Y. Acad. Sci. pmid:18056955
Wu ZQ et al. Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. 2007 Chin. Med. J. pmid:18167185
Shimazu T et al. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. 2007 J. Biol. Chem. pmid:17172643
Januchowski R and Jagodzinski PP Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. 2007 Int. Immunopharmacol. pmid:17178387
Cras A et al. Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. 2007 Oncogene pmid:17213810
Honda H et al. Regulation of the CLDN3 gene in ovarian cancer cells. 2007 Cancer Biol. Ther. pmid:17986852
Renthal W et al. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 2007 Neuron pmid:17988634
Carén H et al. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. 2007 Br. J. Cancer pmid:17940511