| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myelomonocytic, Acute | D015479 | 6 associated lipids |
| Uveal Neoplasms | D014604 | 3 associated lipids |
| Opioid-Related Disorders | D009293 | 5 associated lipids |
| Neuroendocrine Tumors | D018358 | 4 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Conjunctival Neoplasms | D003230 | 3 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Ganglioneuroma | D005729 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Lupus Vulgaris | D008177 | 1 associated lipids |
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Lymphoma, Follicular | D008224 | 3 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Laska MJ et al. | (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. | 2013 | PLoS ONE | pmid:23382858 |
| Bennett KL et al. | AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. | 2009 | PLoS ONE | pmid:19742317 |
| Lv W et al. | Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. | 2014 | PLoS ONE | pmid:25412078 |
| Lu HK et al. | Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. | 2014 | PLoS ONE | pmid:25409334 |
| Pichugin A et al. | Ring-like distribution of constitutive heterochromatin in bovine senescent cells. | 2011 | PLoS ONE | pmid:22132080 |
| Sato T et al. | Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. | 2013 | PLoS ONE | pmid:23555753 |
| Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
| Chandwani S et al. | Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. | 2013 | PLoS ONE | pmid:24204683 |
| Sar P et al. | 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. | 2011 | PLoS ONE | pmid:21687737 |
| Tao Y et al. | HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. | 2015 | PLoS ONE | pmid:25789466 |
| Smirnova L et al. | MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate. | 2014 | PLoS ONE | pmid:24896083 |
| Chang YW and Singh KP | Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells. | 2017 | PLoS ONE | pmid:28323900 |
| Li LF et al. | Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. | 2017 | PLoS ONE | pmid:28234968 |
| Halsall J et al. | Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. | 2012 | PLoS ONE | pmid:22479401 |
| Han B et al. | Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion. | 2013 | PLoS ONE | pmid:24312356 |
| Desjardins D et al. | Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. | 2016 | PLoS ONE | pmid:27617745 |
| Park IH et al. | Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. | 2016 | PLoS ONE | pmid:27571418 |
| Andrews KT et al. | Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. | 2012 | PLoS ONE | pmid:22384084 |
| Kondo Y et al. | Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. | 2014 | PLoS ONE | pmid:25084468 |
| Agudelo M et al. | Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. | 2016 | PLoS ONE | pmid:27249803 |
| Spin JM et al. | Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. | 2010 | PLoS ONE | pmid:21179216 |
| Estella C et al. | Inhibition of histone deacetylase activity in human endometrial stromal cells promotes extracellular matrix remodelling and limits embryo invasion. | 2012 | PLoS ONE | pmid:22291969 |
| Cavalieri V and Spinelli G | Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo. | 2015 | PLoS ONE | pmid:26618749 |
| Zhang Y et al. | The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. | 2015 | PLoS ONE | pmid:26606052 |
| Nepelska M et al. | Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. | 2012 | PLoS ONE | pmid:23300800 |
| Gupta K et al. | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | 2012 | PLoS ONE | pmid:23285096 |
| Terhune SS et al. | Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. | 2010 | PLoS Pathog. | pmid:20585571 |
| Condon JC et al. | A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12886011 |
| Xu D et al. | Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11274400 |
| Chen WY and Townes TM | Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10618426 |
| Ma P et al. | Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22223663 |
| Porter NJ et al. | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29203661 |
| Minucci S et al. | A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9326603 |
| Emiliani S et al. | Characterization of a human RPD3 ortholog, HDAC3. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501169 |
| Jenster G et al. | Steroid receptor induction of gene transcription: a two-step model. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9223281 |
| Matoba S et al. | RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22065773 |
| Crump NT et al. | Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21518915 |
| Plouffe D et al. | In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18579783 |
| Carmen AA et al. | Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10535926 |
| Ji Y et al. | A multistep mechanism for the activation of rearrangement in the immune system. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12802019 |
| Liu Z et al. | Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449719 |
| Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
| Kim MY et al. | A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16924111 |
| Monte M et al. | MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16847267 |
| Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
| Sasaki K et al. | Real-time imaging of histone H4 hyperacetylation in living cells. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805290 |
| Gibbs A et al. | Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805354 |
| McCullough SD et al. | Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23236151 |
| Weaver IC et al. | Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16484373 |
| Li B et al. | FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17360565 |