trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Park H et al. | Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. | 2008 | Int. J. Mol. Med. | pmid:18949380 |
| Lin YC et al. | Effects of trichostatin A on neuronal mu-opioid receptor gene expression. | 2008 | Brain Res. | pmid:18950606 |
| Haffner I et al. | Regulation of arginase-1 expression in macrophages by a protein kinase A type I and histone deacetylase dependent pathway. | 2008 | J. Cell. Biochem. | pmid:17577214 |
| Björkman M et al. | Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. | 2008 | Int. J. Cancer | pmid:18798265 |
| Oger F et al. | The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18977200 |
| Albertus DL et al. | AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. | 2008 | J Thorac Oncol | pmid:18978557 |
| Chou CW and Chen CC | HDAC inhibition upregulates the expression of angiostatic ADAMTS1. | 2008 | FEBS Lett. | pmid:19007777 |
| Setiadi AF et al. | Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. | 2008 | Cancer Res. | pmid:19047136 |
| Mizumoto S et al. | The developmental potential of parthenogenetic and somatic cell nuclear-transferred rat oocytes in vitro. | 2008 | Cloning Stem Cells | pmid:19049415 |
| Slack MD et al. | Characterizing heterogeneous cellular responses to perturbations. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19052231 |
| Chittur SV et al. | Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | 2008 | BMC Genomics | pmid:18959802 |
| Hayashi K et al. | Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. | 2008 | Cell Stem Cell | pmid:18940731 |
| Ridolfi E et al. | Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. | 2008 | Br. J. Cancer | pmid:18941460 |
| Cao W et al. | Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. | 2008 | J. Exp. Med. | pmid:18504304 |
| Bigl M et al. | Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18938139 |
| Ramirez T et al. | Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. | 2008 | Chromosoma | pmid:17999076 |
| Zhang S et al. | Effect of trichostatin a on viability and microRNA expression in human pancreatic cancer cell line BxPC-3. | 2008 | Exp. Oncol. | pmid:19112422 |
| Malinen M et al. | Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3. | 2008 | Nucleic Acids Res. | pmid:17999998 |
| Kim TY et al. | Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. | 2008 | Exp. Mol. Med. | pmid:19116449 |
| Schäfer S et al. | Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). | 2008 | Bioorg. Med. Chem. | pmid:18054239 |
| Jiang SJ et al. | [Effects of trichostatin A and paclitaxel on apoptosis and microtubule stabilization in endometrial carcinoma cells: an in vitro research]. | 2008 | Zhonghua Yi Xue Za Zhi | pmid:19087722 |
| Shi LH et al. | Trichostatin A and nuclear reprogramming of cloned rabbit embryos. | 2008 | J. Anim. Sci. | pmid:18245503 |
| Paris M et al. | Histone deacetylase inhibitors: from bench to clinic. | 2008 | J. Med. Chem. | pmid:18247554 |
| Gupta MP et al. | HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. | 2008 | J. Biol. Chem. | pmid:18250163 |
| Politis PK et al. | BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells. | 2008 | FEBS Lett. | pmid:18258204 |
| Isakov E et al. | Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica. | 2008 | Mol. Biochem. Parasitol. | pmid:18191469 |
| Andrews KT et al. | Potent antimalarial activity of histone deacetylase inhibitor analogues. | 2008 | Antimicrob. Agents Chemother. | pmid:18212103 |
| Heller G et al. | Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells. | 2008 | Cancer Res. | pmid:18172295 |
| Yildirim F et al. | Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. | 2008 | Exp. Neurol. | pmid:18234195 |
| Tang Y et al. | Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. | 2008 | Circ. Res. | pmid:18239137 |
| Wang Q et al. | The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis. | 2008 | Cell Cycle | pmid:18239470 |
| Balakrishnan L and Milavetz B | HDAC inhibitors stimulate viral transcription by multiple mechanisms. | 2008 | Virol. J. | pmid:18353181 |
| Kimata Y et al. | Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. | 2008 | J. Cell. Sci. | pmid:18354085 |
| Suuronen T et al. | Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90. | 2008 | Neurochem. Res. | pmid:18307035 |
| Dalgard CL et al. | Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. | 2008 | Clin. Cancer Res. | pmid:18483379 |
| Jiang Y et al. | Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes. | 2008 | J. Exp. Biol. | pmid:18310117 |
| Egler V et al. | Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death. | 2008 | Clin. Cancer Res. | pmid:18483381 |
| Dong G et al. | Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18310471 |
| Chen Y et al. | A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. | 2008 | J. Med. Chem. | pmid:18494463 |
| Kim M et al. | Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. | 2008 | Mol. Cancer Res. | pmid:18314483 |
| Sun C and Zhou J | Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2. | 2008 | Biochem. Pharmacol. | pmid:18495085 |
| Schuetz A et al. | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. | 2008 | J. Biol. Chem. | pmid:18285338 |
| Ma P and Schultz RM | Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. | 2008 | Dev. Biol. | pmid:18501342 |
| Horswill MA et al. | Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts. | 2008 | Exp. Eye Res. | pmid:18291368 |
| Chung KS et al. | Fission yeast-based screening to identify putative HDAC inhibitors using a telomeric reporter strain. | 2008 | Mol. Cells | pmid:18525239 |
| Countryman JK et al. | Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors. | 2008 | J. Virol. | pmid:18337569 |
| Makki MS et al. | TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. | 2008 | Nucleic Acids Res. | pmid:18535006 |
| Borghol N et al. | Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes. | 2008 | Genomics | pmid:18343090 |
| Hoffmann K et al. | Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases? | 2008 | Epilepsy Res. | pmid:18538545 |
| Jiang X et al. | DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. | 2008 | Cancer Cell | pmid:18538736 |
| Gavin DP et al. | Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. | 2008 | Schizophr. Res. | pmid:18539439 |
| Lecona E et al. | Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase. | 2008 | Mol. Cell. Biol. | pmid:18541673 |
| Wu X et al. | Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development. | 2008 | Anim. Biotechnol. | pmid:18855246 |
| Li J et al. | High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos. | 2008 | Theriogenology | pmid:18573521 |
| Karantzali E et al. | Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis. | 2008 | Genome Biol. | pmid:18394158 |
| Ree AH et al. | HDAC2 deficiency and histone acetylation. | 2008 | Nat. Genet. | pmid:18583969 |
| Galiová G et al. | Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. | 2008 | Eur. J. Cell Biol. | pmid:18396346 |
| Liu Y et al. | Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines. | 2008 | Cancer Invest. | pmid:18584348 |
| Geli J et al. | Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma. | 2008 | Int. J. Cancer | pmid:18452173 |
| Nakao Y et al. | Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18397826 |
| Mazitschek R et al. | Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18430569 |
| Chen PC et al. | Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group. | 2008 | Bioorg. Med. Chem. | pmid:18397827 |
| Kim B et al. | Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. | 2008 | Eur. J. Pharmacol. | pmid:18550052 |
| Habold C et al. | Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. | 2008 | J. Cell. Mol. Med. | pmid:18419600 |
| Yan C et al. | Comparative molecular dynamics simulations of histone deacetylase-like protein: binding modes and free energy analysis to hydroxamic acid inhibitors. | 2008 | Proteins | pmid:18398905 |
| Tavera-Mendoza LE et al. | Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18550844 |
| Romieu P et al. | Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats. | 2008 | J. Neurosci. | pmid:18799668 |
| Ko JM et al. | Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. | 2008 | Mol. Cancer Res. | pmid:18403638 |
| Lee TB et al. | Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. | 2008 | BMC Gastroenterol | pmid:18673531 |
| Chan DW et al. | Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells. | 2008 | Int. J. Cancer | pmid:18553387 |
| Roy S et al. | Histone deacetylase 5 represses the transcription of cyclin D3. | 2008 | J. Cell. Biochem. | pmid:18404677 |
| Xiang N et al. | Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. | 2008 | Carcinogenesis | pmid:18676679 |
| Kawamoto K et al. | DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines. | 2008 | Int. J. Cancer | pmid:18404682 |
| Northrop JK et al. | Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells. | 2008 | J. Immunol. | pmid:18606637 |
| Kaipparettu BA et al. | Estrogen-mediated downregulation of CD24 in breast cancer cells. | 2008 | Int. J. Cancer | pmid:18404683 |
| Schmeck B et al. | Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression. | 2008 | J. Immunol. | pmid:18606645 |
| Jeseta M et al. | In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A. | 2008 | Zygote | pmid:18405435 |
| Miyanaga A et al. | Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model. | 2008 | Mol. Cancer Ther. | pmid:18606719 |
| Lin YC et al. | Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. | 2008 | Cancer Res. | pmid:18381445 |
| Tischler JL et al. | Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors. | 2008 | J Enzyme Inhib Med Chem | pmid:18608778 |
| Chu F et al. | Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway. | 2008 | Aging Cell | pmid:18489729 |
| Wu JY et al. | Enhancement of glutamate uptake in 1-methyl-4-phenylpyridinium-treated astrocytes by trichostatin A. | 2008 | Neuroreport | pmid:18628666 |
| Shakèd M et al. | Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling. | 2008 | PLoS ONE | pmid:18628975 |
| Su RC et al. | Epigenetic regulation of established human type 1 versus type 2 cytokine responses. | 2008 | J. Allergy Clin. Immunol. | pmid:17980413 |
| Yu J et al. | Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. | 2008 | Hepatology | pmid:18666234 |
| Iacobazzi V et al. | Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706393 |
| Falk M et al. | Chromatin structure influences the sensitivity of DNA to gamma-radiation. | 2008 | Biochim. Biophys. Acta | pmid:18706456 |
| Schauber J et al. | Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. | 2008 | J. Invest. Dermatol. | pmid:17943182 |
| Zhang XH et al. | Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer. | 2008 | Cancer Biol. Ther. | pmid:18708766 |
| Chen J et al. | Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis. | 2008 | Chem. Biol. Interact. | pmid:17961528 |
| Yang YN et al. | [Effects of trichostatin A and paclitaxel on apoptosis and mitochondrial membrane potential of human endometrial carcinoma Ark2 cells]. | 2008 | Ai Zheng | pmid:18710614 |
| Obrdlik A et al. | The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription. | 2008 | Mol. Cell. Biol. | pmid:18710935 |
| Haumaitre C et al. | Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. | 2008 | Mol. Cell. Biol. | pmid:18710955 |
| Kim M et al. | LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer. | 2008 | Cancer Res. | pmid:18757430 |
| Ma Y et al. | Inhibition of protein deacetylation by trichostatin A impairs microtubule-kinetochore attachment. | 2008 | Cell. Mol. Life Sci. | pmid:18759129 |
| Zhang Y et al. | Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. | 2008 | J. Immunol. | pmid:18097041 |
| Jin B et al. | DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. | 2008 | Hum. Mol. Genet. | pmid:18029387 |
| Gan Y et al. | Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:17996726 |
| Lee EJ et al. | Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. | 2008 | Int. J. Oncol. | pmid:18813790 |
| Van Wagoner DR and Nattel S | Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. | 2008 | J. Mol. Cell. Cardiol. | pmid:18817781 |