trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhou Q et al. | Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. | 2008 | Mol. Vis. | pmid:19122829 |
| Hajji N et al. | Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. | 2008 | Oncogene | pmid:18071312 |
| Walton TJ et al. | DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. | 2008 | Prostate | pmid:18092350 |
| Arany I et al. | Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18094030 |
| Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
| Byers J and Eichinger D | Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. | 2008 | Int. J. Parasitol. | pmid:17706222 |
| Kang JH et al. | CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. | 2008 | J. Cell. Biochem. | pmid:18275041 |
| Oliva J et al. | Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. | 2008 | Exp. Mol. Pathol. | pmid:18280469 |
| Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
| Yu C et al. | Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. | 2008 | Neuro-oncology | pmid:18445700 |
| Yu WP et al. | Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells. | 2008 | Cell Prolif. | pmid:18211287 |
| Jensen TJ et al. | Epigenetic remodeling during arsenical-induced malignant transformation. | 2008 | Carcinogenesis | pmid:18448484 |
| van West P et al. | Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling. | 2008 | Microbiology (Reading, Engl.) | pmid:18451057 |
| Liu Z et al. | Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells. | 2008 | Oncol. Rep. | pmid:18575731 |
| Plouffe D et al. | In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18579783 |
| Sun Y et al. | Modulation of transcription parameters in glucocorticoid receptor-mediated repression. | 2008 | Mol. Cell. Endocrinol. | pmid:18583028 |
| Pryzbylkowski P et al. | Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. | 2008 | Breast Cancer Res. Treat. | pmid:17891453 |
| Vrbova G | Spinal muscular atrophy: motoneurone or muscle disease? | 2008 | Neuromuscul. Disord. | pmid:18365338 |
| Iager AE et al. | Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos. | 2008 | Cloning Stem Cells | pmid:18419249 |
| Liu TC et al. | Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. | 2008 | Mol. Ther. | pmid:18388912 |
| Hayakawa F et al. | Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis. | 2008 | J. Biol. Chem. | pmid:18621739 |
| Reilly CM et al. | The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. | 2008 | J. Autoimmun. | pmid:18650065 |
| Law AY et al. | Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation. | 2008 | Exp. Cell Res. | pmid:18652825 |
| Bosisio D et al. | Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. | 2008 | J. Leukoc. Biol. | pmid:18780875 |
| Yang L et al. | [Effect of decitabine combined with Trichostatin A on MDS cell line SKM-1 in vitro]. | 2008 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18718068 |
| Zou XM et al. | Gastric cancer cell lines induced by trichostatin A. | 2008 | World J. Gastroenterol. | pmid:18720545 |
| Liu F et al. | Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. | 2008 | J. Mol. Cell. Cardiol. | pmid:18926829 |
| Gu Z et al. | Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas. | 2008 | Genes Genet. Syst. | pmid:18931460 |
| Wu Y and Guo SW | Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. | 2008 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17376583 |
| Jin B et al. | DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. | 2008 | Hum. Mol. Genet. | pmid:18029387 |
| Lee EJ et al. | Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. | 2008 | Int. J. Oncol. | pmid:18813790 |
| Van Wagoner DR and Nattel S | Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. | 2008 | J. Mol. Cell. Cardiol. | pmid:18817781 |
| Cheli Y et al. | Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. | 2007 Sep-Oct | Biochim. Biophys. Acta | pmid:17669516 |
| Yasuda K et al. | ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells. | 2007 Nov-Dec | Anticancer Res. | pmid:18225573 |
| Kuwajima A et al. | The histone deacetylase inhibitor butyrate inhibits melanoma cell invasion of Matrigel. | 2007 Nov-Dec | Anticancer Res. | pmid:18225587 |
| Hosseinkhani M et al. | Trichostatin A induces myocardial differentiation of monkey ES cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17368572 |
| Kim HJ et al. | Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371805 |
| Kishigami S et al. | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. | 2007 | J. Reprod. Dev. | pmid:17077581 |
| Castro-Galache MD et al. | Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17588800 |
| Nagashima T et al. | Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis. | 2007 | Mol. Hum. Reprod. | pmid:17267518 |
| Sakuma M et al. | Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. | 2007 | Cancer Sci. | pmid:17270028 |
| Kim SH et al. | Regulation of the HIF-1alpha stability by histone deacetylases. | 2007 | Oncol. Rep. | pmid:17273746 |
| Ou JN et al. | Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. | 2007 | Biochem. Pharmacol. | pmid:17276411 |
| Hatjiharissi E et al. | Proteomic analysis of waldenstrom macroglobulinemia. | 2007 | Cancer Res. | pmid:17440091 |
| Liu TX et al. | Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. | 2007 | Nat. Med. | pmid:17159988 |
| Cecconi D et al. | Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. | 2007 | Proteomics | pmid:17443844 |
| Yoshikawa M et al. | Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. | 2007 | J. Am. Soc. Nephrol. | pmid:17135397 |
| Higashi T et al. | Histone H2A mobility is regulated by its tails and acetylation of core histone tails. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17445770 |
| Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
| Hellebrekers DM et al. | Identification of epigenetically silenced genes in tumor endothelial cells. | 2007 | Cancer Res. | pmid:17483324 |
| Yi T et al. | Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis. | 2007 | Exp. Mol. Med. | pmid:17464183 |
| Long JE and Cai X | Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle. | 2007 | Gene | pmid:17150312 |
| Strobl JS et al. | Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. | 2007 | J. Parasitol. | pmid:17626366 |
| Ho AK et al. | Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. | 2007 | Endocrinology | pmid:17628002 |
| Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17679169 |
| Sun DF et al. | [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. | 2007 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:17680526 |
| Peng Y et al. | The histone deacetylase inhibitor sodium butyrate inhibits baculovirus-mediated transgene expression in Sf9 cells. | 2007 | J. Biotechnol. | pmid:17655959 |
| Li YL et al. | [Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. | 2007 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:17659468 |
| Wu Y et al. | The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. | 2007 | Genes Cells | pmid:17663720 |
| Schneider G et al. | HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. | 2007 | Cell Prolif. | pmid:17635519 |
| Xin C et al. | FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism. | 2007 | Br. J. Pharmacol. | pmid:17325654 |
| Hishiki T et al. | BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3. | 2007 | J. Biol. Chem. | pmid:17644518 |
| Wu Y et al. | Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. | 2007 | Reprod Sci | pmid:17644810 |
| Wang CT and Meng M | [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17650409 |
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| Woo HJ et al. | Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells. | 2007 | Exp. Mol. Pathol. | pmid:16574101 |
| Park JJ et al. | Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. | 2007 | J. Gen. Virol. | pmid:18024889 |
| Januchowski R et al. | Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. | 2007 | Cancer Lett. | pmid:16624484 |
| Araki H et al. | Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. | 2007 | Blood | pmid:17185465 |
| Lee EL et al. | Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. | 2007 | J. Cell. Physiol. | pmid:17186499 |
| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Tsaprouni LG et al. | Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. | 2007 | Clin. Exp. Immunol. | pmid:17711487 |
| Yasukawa K et al. | Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts. | 2007 | Br. J. Dermatol. | pmid:17711521 |
| Frye M et al. | Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. | 2007 | PLoS ONE | pmid:17712411 |
| Adcock IM et al. | Epigenetic regulation of airway inflammation. | 2007 | Curr. Opin. Immunol. | pmid:17720468 |
| Zhang Y et al. | Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. | 2007 | Radiat. Res. | pmid:17722998 |
| Zhou X et al. | The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. | 2007 | Cancer Genet. Cytogenet. | pmid:17693185 |
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| Katz RA et al. | High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. | 2007 | J. Virol. | pmid:17202206 |
| De los Santos M et al. | Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. | 2007 | Mol. Cancer Ther. | pmid:17431121 |
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| Hashii M et al. | Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17367762 |